Listing of research core items
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Services
RNA & 2'-O-methyl RNA
We synthesize RNA and 2'-O-methyl RNA only at the 1.0 µmole scale.
Located within Keck Oligo Synthesis ResourceContact us
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Services
Single-cell genomics and proteomics analysis
Learn about 10X Genomics, Parse Biosciences, and Bruker Isospark technologies.
Located within Keck Microarray Shared ResourcePrimary contact
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Services
UltraMild synthesis
Some modifications require the use of UltraMild columns, phosphoramidites, and reagents that allow for mild cleavage and deprotection conditions.
Located within Keck Oligo Synthesis ResourceContact us
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Services
Spatial genomics and proteomics analysis
Next-generation molecular profiling solution for classifying tissue based on total mRNA. Morphological context in spatial transcriptomics and spatial proteomics experiments from one slide. 10x Genomics Visium and Nanostring GeoMX.
Located within Keck Microarray Shared ResourcePrimary contact
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Services
Long-read sequencing
Solutions from Oxford Nanopore and PacBio.
Located within Keck Microarray Shared ResourcePrimary contact
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Services
Global metabolomics and integrative -omics (intOmics)
Metabolomics provides screening of targeted (~650) and untargeted (~2500) metabolites.
Located within Chemical Metabolism CoreStephan Siebel, MD, PhD
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Instrument/equipment
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Instrument/equipment
Super-resolution and confocal microscopes
Learn about our Abberior STEDYCON, Andor BC43, Leica SP8, Leica Stellaris 8 Falcon, and Nikon CSU-W1.
Located within West Campus Imaging Core -
Instrument/equipment
Light sheet microscope
Miltenyi UM Blaze is a a user-friendly light sheet microscope designed for subcellular 3D imaging of large and multiple samples.
Located within West Campus Imaging Core -
Services
Metabolic flux and enrichment studies using MIMOSA
In this subcore, parameters of cellular and tissue metabolic flux are assessed by incorporation of stable isotope-labeled tracers (e.g., carbon-13, nitrogen-15, or deuterium) into metabolism. The CMC uses the targeted mass isotopomer multi-ordinate spectral analysis (MIMOSA) platform to interpret stable isotope labeling patterns for calculation of rates of discrete steps in glycolytic and mitochondrial metabolism. Such measurements can be used to identify differences in fuel usage (e.g., glycolysis vs. beta-oxidation), and non-oxidative (reductive carboxylation, anaplerosis and cataplerosis) contributions to the TCA cycle.
Located within Chemical Metabolism CoreStephan Siebel, MD, PhD
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Instrument/equipment
NMR
Our NMR instruments include a Bruker 400 MHz broadband probe and an Agilent DD2 600 MHz 3 mm cold probe.
Located within West Campus Analytical Core -
Instrument/equipment