Cores Directory

Search for the resources you need to answer your research questions.

170 results found

Listing of research core items

  1. Instrument/equipment

    Atomic force microscopy

    A Bruker Dimension Fastscan AFM provides atomic force microscopy in both air and fluids using the new “Peak Force” tapping mode as well as very high speed resonant tapping mode.

    Sungwoo Sohn, PhD

    Associate Director of Facilities
  2. Instrument/equipment

    Image analysis workstation

    IMARIS and MACS iQ View

    Located within West Campus Imaging Core

    Joerg Nikolaus, PhD

    Director
  3. Services
    Scientist at a workstation

    Islet isolation and function

    In this subcore, our technical expertise in isolating rodent islets including rats, mice, and most recently ground squirrel from the pancreas ex vivo allows researchers to study the intact islets for their studies or to proceed with substrate-stimulated insulin secretion functional studies using our BioRep Technologies Islet Perfusion Systems (8-channel and 12-channel). For non-rodent islet studies, human donor islet procurement assistance as well as functional studies are also offered.

    Located within Chemical Metabolism Core

    Rebecca Cardone, MS

  4. Instrument/equipment

    Optical

    Optical instrumentation

    Terence Wu

    Director
  5. Instrument/equipment

    Atomic force microscope

    Asylum Research Cypher AFM

    Located within West Campus Imaging Core

    Joerg Nikolaus, PhD

    Director
  6. Services
    Two scientists examine a monitor

    Cellular and mitochondrial respiration and bioenergetics

    Cellular and mitochondrial respiration (OCR) and acidification (ECAR) are assessed with the Agilent Seahorse XF Pro 96. In a 96-well plate format, real-time measurements of cellular respiration, oxidative phosphorylation, mitochondrial leak, and mitochondrial transport are assessed as functional kinetic measurements of cellular bioenergetics. Changes in acidification are also observed simultaneously. An integrated Agilent BioTek Cytation5 imager correlates cell number via Hoechst nuclear stain to respiration for more accurate normalization of respiration.

    Located within Chemical Metabolism Core

    Rebecca Cardone, MS

  7. Core/facility
    STEM ADF at 60 kV

    Aberration-Corrected Electron Microscopy (ACEM) Core

    Our core's focus is cutting-edge and high-throughput capability in electron microscopy techniques, including TEM, SEM, and FIB.

    Primary contact

    Shize Yang, PhD
  8. Instrument/equipment

    Abrasive water jet cutting

    The high-pressure abrasive water jet cutter can be best thought of as a computer-controlled bandsaw. It is largely used to cut through flat material stock.

    Craig Miller

    Primary contact
  9. Core/facility

    Advanced Instrumentation Development Center (AIDC)

    Our mission stands at the nexus between hardware, computing, and data science.

    AIDC

  10. Core/facility
    Red light image of a laser

    Advanced Prototyping Center at Wright Lab

    The Advanced Prototyping Center is a fabrication and design support facility to help Yale researchers with custom instrumentation.

    Craig Miller

    Primary contact
  11. Core/facility

    Yale Analytical and Stable Isotope Center (YASIC)

    Our analytical services include measurements of stable and radiocarbon isotopes, cations, anions, greenhouse gases, natural γ-radiation, mercury, and nutrients in water or soil extracts.

    Brad Erkkila

    Primary contact Director
  12. Core/facility

    Yale Animal Resources Center (YARC)

    Animal resources for Yale researchers.

    See website