West Campus Analytical Core

Terence Wu

Director
Building:

600 West Campus Drive (MIC)

About the core

The WCAC is an open-access facility where researchers learn to operate and collect data on a wide variety of scientific instruments suitable for the characterization and structure elucidation of chemical and biophysical samples. We have a primary instrumentation focus in the areas of mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy, and we have additional resources in proteomics, optical instrumentation, and biophysical instrumentation.

If you are new to Yale, or if you are in the local area and need access to any of our instruments, please request an account, and we will contact you to set up a training session and help you get started using our instruments. We charge a fee for instrument usage, typically accounted on a per-sample or time basis. The income from these fees is used to help offset the operational and maintenance costs of our instruments, and we strive to keep these fees as low as possible. After you have received training, ensuring that all of your instrument usage is appropriately logged or reserved online will help us in our mission of a low-fee and well-maintained instrument center.

Available to Yale researchers & external researchers

Policies

  1. Acknowledgments
  2. Facilities access
  3. Training
  4. Instrument reservations
  5. Data storage

Acknowledgments

If you use WCAC instruments in your research, we request that you acknowledge our facility in your written publications or grant applications as follows:

Acknowledgment: This research made use of the West Campus Analytical Core at Yale University. 

Send a citation or a copy of the publication to staff for record-keeping purposes. This information is important to help support our mission and to demonstrate the need for the equipment and staff expertise within the WCAC.

WCAC staff recognition on projects requiring a large investment of time or a significant intellectual contribution by the WCAC will be discussed on an individual basis.

Facilities access

Active users will have access to MIC 109 and MIC 119 and access can be requested by emailing WCAC staff. In order to request access, users will fill out the West Campus Access Form.  Active WCAC users will have access to booking calendars and instruments on which they have been trained by WCAC staff.

Training

We provide training on instruments at WCAC. All new users are required to have instrument training by WCAC staff before being granted access to WCAC and instruments. Training will be served individually or in small groups as scheduling allows. Please contact WCAC staff to request a training session. (Bruker NMR on-demand trainings are here.)

Instrument reservations

Most WCAC instruments are reservation-only except for the below:

FOM: AG 600 MHz NMR instrument

Walk-in: UV/Vis spectrophotometers, FTIR, GC-MS, SQ-MS, and HPLC

Log usage of all instruments on the clipboard next to the instrument, if instrument time was not reserved online.

Data storage

Data acquired by analytical instruments is currently stored on the instrument’s hard drive and archived on a temporary basis. Users are asked to back up their own data. If you have questions about this, please ask WCAC staff.

Publications

Selected publications by WCAC users


Wisnewski, Adam V; Liu, Jian; Redlich, Carrie A; Nassar, Ala F; Polymerization of hexamethylene diisocyanate in solution and a 260.23 m/z [M+ H]+ ion in exposed human cells; Analytical biochemistry, 543, 21-29, 2018.

Jiang, Jianbing; Matula, Adam J; Swierk, John R; Romano, Neyen; Wu, Yueshen; Batista, Victor S; Crabtree, Robert H; Lindsey, Jonathan S; Wang, Hailiang; Brudvig, Gary W; Unusual Stability of a Bacteriochlorin Electrocatalyst under Reductive Conditions. A Case Study on CO2 Conversion to CO, ACS Catalysis, 2018.

Ye, Yunpeng; Toczek, Jakub; Gona, Kiran; Kim, Hye-Yeong; Han, Jinah; Razavian, Mahmoud; Golestani, Reza; Zhang, Jiasheng; Wu, Terence L; Ghosh, Mousumi; Novel Arginine-containing Macrocyclic MMP Inhibitors: Synthesis, 99m Tc-labeling, and Evaluation, Scientific reports, 8, 1, 11647, 2018

Jiang, Jianbing; Spies, Jacob A; Swierk, John R; Matula, Adam J; Regan, Kevin P; Romano, Neyen; Brennan, Bradley J; Crabtree, Robert H; Batista, Victor S; Schmuttenmaer, Charles A; Direct Interfacial Electron Transfer from High-Potential Porphyrins into Semiconductor Surfaces: A Comparison of Linkers and Anchoring Groups, The Journal of Physical Chemistry C, 2018.

Schofield, Jeremy A; Duffy, Erin E; Kiefer, Lea; Sullivan, Meaghan C; Simon, Matthew D; TimeLapse-seq: adding a temporal dimension to RNA sequencing through nucleoside recoding, Nature methods, 15, 3, 221, 2018

Toczek, Jakub; Ye, Yunpeng; Gona, Kiran; Kim, Hye-Yeong; Han, Jinah; Razavian, Mahmoud; Golestani, Reza; Zhang, Jiasheng; Wu, Terence L; Jung, Jae-Joon; Preclinical Evaluation of RYM1, a Matrix Metalloproteinase-Targeted Tracer for Imaging Aneurysm.Journal of nuclear medicine: official publication, Society of Nuclear Medicine, 58, 8, 1318-1323, 2017,

Fischer, Caleb N; Trautman, Eric P; Crawford, Jason M; Stabb, Eric V; Handelsman, Jo; Broderick, Nichole A; Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior, Elife, 6, 2017

Lee, Shin Hee; Regan, Kevin P; Hedström, Svante; Matula, Adam J; Chaudhuri, Subhajyoti; Crabtree, Robert H; Batista, Victor S; Schmuttenmaer, Charles A; Brudvig, Gary W; Linker Length-Dependent Electron-Injection Dynamics of Trimesitylporphyrins on SnO2 Films, The Journal of Physical Chemistry C, 121, 41, 22690-22699, 2017

Jiang, Jianbing; Materna, Kelly L; Hedström, Svante; Yang, Ke R; Crabtree, Robert H; Batista, Victor S; Brudvig, Gary W; Antimony Complexes for Electrocatalysis: Activity of a Main‐Group Element in Proton Reduction, Angewandte Chemie International Edition, 56, 31, 9111-9115, 2017

Golestani, Reza; Razavian, Mahmoud; Ye, Yunpeng; Zhang, Jiasheng; Jung, Jae-Joon; Toczek, Jakub; Gona, Kiran; Kim, Hye-Yeong; Elias, Jack A; Lee, Chun Geun; Matrix Metalloproteinase–Targeted Imaging of Lung Inflammation and Remodeling, Journal of Nuclear Medicine, 58, 1, 138, 2017

Jiang, Jianbing; Crabtree, Robert H; Brudvig, Gary W; One-Step Trimethylstannylation of Benzyl and Alkyl Halides, The Journal of organic chemistry, 81, 19, 9483-9488, 2016.

Jiang, Jianbing; Swierk, John R; Materna, Kelly L; Hedström, Svante; Lee, Shin Hee; Crabtree, Robert H; Schmuttenmaer, Charles A; Batista, Victor S; Brudvig, Gary W; High-Potential Porphyrins Supported on SnO2 and TiO2 Surfaces for Photoelectrochemical Applications, The Journal of Physical Chemistry C, 120, 51, 28971-28982, 2016

Koenigsmann, Christopher; Ding, Wendu; Koepf, Matthieu; Batra, Arunabh; Venkataraman, Latha; Negre, Christian FA; Brudvig, Gary W; Crabtree, Robert H; Batista, Victor S; Schmuttenmaer, Charles A; Structure–function relationships in single molecule rectification by N-phenylbenzamide derivatives, New Journal of Chemistry, 40, 9, 7373-7378, 2016

Koepf, Matthieu; Koenigsmann, Christopher; Ding, Wendu; Batra, Arunbah; Negre, Christian FA; Venkataraman, Latha; Brudvig, Gary W; Batista, Victor S; Schmuttenmaer, Charles A; Crabtree, Robert H; Controlling the rectification properties of molecular junctions through molecule–electrode coupling, Nanoscale, 8, 36, 16357-16362, 2016

Van Dyke, Aaron R; Etemad, Lily S; Vessicchio, Michael J; Naclerio, George A; Jedson, Victoria; Capture‐Tag‐Release: A Strategy for Small Molecule Labeling of Native Enzymes, ChemBioChem, 17, 17, 1602-1605, 2016

Weng, Zhe; Jiang, Jianbing; Wu, Yueshen; Wu, Zishan; Guo, Xiaoting; Materna, Kelly L; Liu, Wen; Batista, Victor S; Brudvig, Gary W; Wang, Hailiang; Electrochemical CO2 reduction to hydrocarbons on a heterogeneous molecular Cu catalyst in aqueous solution, Journal of the American Chemical Society, 138, 26, 8076-8079, 2016

Fischer, Caleb N; Trautman, Eric P; Crawford, Jason M; Stabb, Eric V; Broderick, Nichole A; Handelsman, Jo; Metabolite exchange within the microbiome produces compounds that influence Drosophila behavior, 66035, 2016

Koepf, Matthieu; Lee, Shin Hee; Brennan, Bradley J; Méndez-Hernández, Dalvin D; Batista, Victor S; Brudvig, Gary W; Crabtree, Robert H; Preparation of Halogenated Fluorescent Diaminophenazine Building Blocks, The Journal of organic chemistry.The Journal of organic chemistry, 80, 20, 9881-9888, 2015.

Brennan, Bradley J; Durrell, Alec C; Koepf, Matthieu; Crabtree, Robert H; Brudvig, Gary W; Towards multielectron photocatalysis: a porphyrin array for lateral hole transfer and capture on a metal oxide surface, Physical Chemistry Chemical Physics, 17, 19, 12728-12734, 2015

Amiram, Miriam; Haimovich, Adrian D; Fan, Chenguang; Wang, Yane-Shih; Aerni, Hans-Rudolf; Ntai, Ioanna; Moonan, Daniel W; Ma, Natalie J; Rovner, Alexis J; Hong, Seok Hoon; Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids, Nature biotechnology, 33, 12, 1272, 2015

Colangelo, Christopher M; Shifman, Mark; Cheung, Kei-Hoi; Stone, Kathryn L; Carriero, Nicholas J; Gulcicek, Erol E; Lam, TuKiet T; Wu, Terence; Bjornson, Robert D; Bruce, Can; YPED: an integrated bioinformatics suite and database for mass spectrometry-based proteomics research, Genomics, proteomics & bioinformatics, 13, 1, 25-35, 2015

Brennan, Bradley J; Gust, Devens; Brudvig, Gary W; Organosilatrane building blocks, Tetrahedron Letters, 5, 55, 1062-1064, 2014

Contacts

Main instrumentation lab and staff:
600 West Campus Drive
Molecular Innovations Center room 109
West Haven, CT 06516

(West Campus map, driving directions, Yale shuttle schedule)

Primary contact

Terence Wu Director

Secondary contact

Jandi Kim, PhD Staff Scientist

Faculty Director

Jason Crawford, PhD Professor of Chemistry and Associate Professor of Microbial Pathogenesis