West Campus Analytical Core
About the core
The WCAC is an open-access facility where researchers learn to operate and collect data on a wide variety of scientific instruments suitable for the characterization and structure elucidation of chemical and biophysical samples. We have a primary instrumentation focus in the areas of mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy, and we have additional resources in proteomics, optical instrumentation, and biophysical instrumentation.
If you are new to Yale, or if you are in the local area and need access to any of our instruments, please request an account, and we will contact you to set up a training session and help you get started using our instruments. We charge a fee for instrument usage, typically accounted on a per-sample or time basis. The income from these fees is used to help offset the operational and maintenance costs of our instruments, and we strive to keep these fees as low as possible. After you have received training, ensuring that all of your instrument usage is appropriately logged or reserved online will help us in our mission of a low-fee and well-maintained instrument center.
Available to Yale researchers & external researchers
Policies
Acknowledgments
If you use WCAC instruments in your research, we request that you acknowledge our facility in your written publications or grant applications as follows:
Acknowledgment: This research made use of the West Campus Analytical Core at Yale University.
Send a citation or a copy of the publication to staff for record-keeping purposes. This information is important to help support our mission and to demonstrate the need for the equipment and staff expertise within the WCAC.
WCAC staff recognition on projects requiring a large investment of time or a significant intellectual contribution by the WCAC will be discussed on an individual basis.
Facilities access
Active users will have access to MIC 109 and MIC 119 and access can be requested by emailing WCAC staff. In order to request access, users will fill out the West Campus Access Form. Active WCAC users will have access to booking calendars and instruments on which they have been trained by WCAC staff.
Training
We provide training on instruments at WCAC. All new users are required to have instrument training by WCAC staff before being granted access to WCAC and instruments. Training will be served individually or in small groups as scheduling allows. Please contact WCAC staff to request a training session. (Bruker NMR on-demand trainings are here.)
Instrument reservations
Most WCAC instruments are reservation-only except for the below:
FOM: AG 600 MHz NMR instrument Walk-in: UV/Vis spectrophotometers, FTIR, GC-MS, SQ-MS, and HPLC |
Log usage of all instruments on the clipboard next to the instrument, if instrument time was not reserved online.
Data storage
Data acquired by analytical instruments is currently stored on the instrument’s hard drive and archived on a temporary basis. Users are asked to back up their own data. If you have questions about this, please ask WCAC staff.
Publications
Selected publications by WCAC users
Wisnewski, Adam V; Liu, Jian; Redlich, Carrie A; Nassar, Ala F; Polymerization of hexamethylene diisocyanate in solution and a 260.23 m/z [M+ H]+ ion in exposed human cells; Analytical biochemistry, 543, 21-29, 2018.
Jiang, Jianbing; Matula, Adam J; Swierk, John R; Romano, Neyen; Wu, Yueshen; Batista, Victor S; Crabtree, Robert H; Lindsey, Jonathan S; Wang, Hailiang; Brudvig, Gary W; Unusual Stability of a Bacteriochlorin Electrocatalyst under Reductive Conditions. A Case Study on CO2 Conversion to CO, ACS Catalysis, 2018.
Ye, Yunpeng; Toczek, Jakub; Gona, Kiran; Kim, Hye-Yeong; Han, Jinah; Razavian, Mahmoud; Golestani, Reza; Zhang, Jiasheng; Wu, Terence L; Ghosh, Mousumi; Novel Arginine-containing Macrocyclic MMP Inhibitors: Synthesis, 99m Tc-labeling, and Evaluation, Scientific reports, 8, 1, 11647, 2018
Jiang, Jianbing; Spies, Jacob A; Swierk, John R; Matula, Adam J; Regan, Kevin P; Romano, Neyen; Brennan, Bradley J; Crabtree, Robert H; Batista, Victor S; Schmuttenmaer, Charles A; Direct Interfacial Electron Transfer from High-Potential Porphyrins into Semiconductor Surfaces: A Comparison of Linkers and Anchoring Groups, The Journal of Physical Chemistry C, 2018.
Schofield, Jeremy A; Duffy, Erin E; Kiefer, Lea; Sullivan, Meaghan C; Simon, Matthew D; TimeLapse-seq: adding a temporal dimension to RNA sequencing through nucleoside recoding, Nature methods, 15, 3, 221, 2018
Toczek, Jakub; Ye, Yunpeng; Gona, Kiran; Kim, Hye-Yeong; Han, Jinah; Razavian, Mahmoud; Golestani, Reza; Zhang, Jiasheng; Wu, Terence L; Jung, Jae-Joon; Preclinical Evaluation of RYM1, a Matrix Metalloproteinase-Targeted Tracer for Imaging Aneurysm.Journal of nuclear medicine: official publication, Society of Nuclear Medicine, 58, 8, 1318-1323, 2017,
Fischer, Caleb N; Trautman, Eric P; Crawford, Jason M; Stabb, Eric V; Handelsman, Jo; Broderick, Nichole A; Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior, Elife, 6, 2017
Lee, Shin Hee; Regan, Kevin P; Hedström, Svante; Matula, Adam J; Chaudhuri, Subhajyoti; Crabtree, Robert H; Batista, Victor S; Schmuttenmaer, Charles A; Brudvig, Gary W; Linker Length-Dependent Electron-Injection Dynamics of Trimesitylporphyrins on SnO2 Films, The Journal of Physical Chemistry C, 121, 41, 22690-22699, 2017
Jiang, Jianbing; Materna, Kelly L; Hedström, Svante; Yang, Ke R; Crabtree, Robert H; Batista, Victor S; Brudvig, Gary W; Antimony Complexes for Electrocatalysis: Activity of a Main‐Group Element in Proton Reduction, Angewandte Chemie International Edition, 56, 31, 9111-9115, 2017
Golestani, Reza; Razavian, Mahmoud; Ye, Yunpeng; Zhang, Jiasheng; Jung, Jae-Joon; Toczek, Jakub; Gona, Kiran; Kim, Hye-Yeong; Elias, Jack A; Lee, Chun Geun; Matrix Metalloproteinase–Targeted Imaging of Lung Inflammation and Remodeling, Journal of Nuclear Medicine, 58, 1, 138, 2017
Jiang, Jianbing; Crabtree, Robert H; Brudvig, Gary W; One-Step Trimethylstannylation of Benzyl and Alkyl Halides, The Journal of organic chemistry, 81, 19, 9483-9488, 2016.
Jiang, Jianbing; Swierk, John R; Materna, Kelly L; Hedström, Svante; Lee, Shin Hee; Crabtree, Robert H; Schmuttenmaer, Charles A; Batista, Victor S; Brudvig, Gary W; High-Potential Porphyrins Supported on SnO2 and TiO2 Surfaces for Photoelectrochemical Applications, The Journal of Physical Chemistry C, 120, 51, 28971-28982, 2016
Koenigsmann, Christopher; Ding, Wendu; Koepf, Matthieu; Batra, Arunabh; Venkataraman, Latha; Negre, Christian FA; Brudvig, Gary W; Crabtree, Robert H; Batista, Victor S; Schmuttenmaer, Charles A; Structure–function relationships in single molecule rectification by N-phenylbenzamide derivatives, New Journal of Chemistry, 40, 9, 7373-7378, 2016
Koepf, Matthieu; Koenigsmann, Christopher; Ding, Wendu; Batra, Arunbah; Negre, Christian FA; Venkataraman, Latha; Brudvig, Gary W; Batista, Victor S; Schmuttenmaer, Charles A; Crabtree, Robert H; Controlling the rectification properties of molecular junctions through molecule–electrode coupling, Nanoscale, 8, 36, 16357-16362, 2016
Van Dyke, Aaron R; Etemad, Lily S; Vessicchio, Michael J; Naclerio, George A; Jedson, Victoria; Capture‐Tag‐Release: A Strategy for Small Molecule Labeling of Native Enzymes, ChemBioChem, 17, 17, 1602-1605, 2016
Weng, Zhe; Jiang, Jianbing; Wu, Yueshen; Wu, Zishan; Guo, Xiaoting; Materna, Kelly L; Liu, Wen; Batista, Victor S; Brudvig, Gary W; Wang, Hailiang; Electrochemical CO2 reduction to hydrocarbons on a heterogeneous molecular Cu catalyst in aqueous solution, Journal of the American Chemical Society, 138, 26, 8076-8079, 2016
Fischer, Caleb N; Trautman, Eric P; Crawford, Jason M; Stabb, Eric V; Broderick, Nichole A; Handelsman, Jo; Metabolite exchange within the microbiome produces compounds that influence Drosophila behavior, 66035, 2016
Koepf, Matthieu; Lee, Shin Hee; Brennan, Bradley J; Méndez-Hernández, Dalvin D; Batista, Victor S; Brudvig, Gary W; Crabtree, Robert H; Preparation of Halogenated Fluorescent Diaminophenazine Building Blocks, The Journal of organic chemistry.The Journal of organic chemistry, 80, 20, 9881-9888, 2015.
Brennan, Bradley J; Durrell, Alec C; Koepf, Matthieu; Crabtree, Robert H; Brudvig, Gary W; Towards multielectron photocatalysis: a porphyrin array for lateral hole transfer and capture on a metal oxide surface, Physical Chemistry Chemical Physics, 17, 19, 12728-12734, 2015
Amiram, Miriam; Haimovich, Adrian D; Fan, Chenguang; Wang, Yane-Shih; Aerni, Hans-Rudolf; Ntai, Ioanna; Moonan, Daniel W; Ma, Natalie J; Rovner, Alexis J; Hong, Seok Hoon; Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids, Nature biotechnology, 33, 12, 1272, 2015
Colangelo, Christopher M; Shifman, Mark; Cheung, Kei-Hoi; Stone, Kathryn L; Carriero, Nicholas J; Gulcicek, Erol E; Lam, TuKiet T; Wu, Terence; Bjornson, Robert D; Bruce, Can; YPED: an integrated bioinformatics suite and database for mass spectrometry-based proteomics research, Genomics, proteomics & bioinformatics, 13, 1, 25-35, 2015
Brennan, Bradley J; Gust, Devens; Brudvig, Gary W; Organosilatrane building blocks, Tetrahedron Letters, 5, 55, 1062-1064, 2014
Contacts
Main instrumentation lab and staff:
600 West Campus Drive
Molecular Innovations Center room 109
West Haven, CT 06516
(West Campus map, driving directions, Yale shuttle schedule)
Primary contact
Secondary contact
Faculty Director
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Core/facility
Aberration-Corrected Electron Microscopy (ACEM) Core
Our core's focus is cutting-edge and high-throughput capability in electron microscopy techniques, including TEM, SEM, and FIB.
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Core/facility
Advanced Prototyping Center at Wright Lab
The Advanced Prototyping Center is a fabrication and design support facility to help Yale researchers with custom instrumentation.
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Core/facility
Yale Analytical and Stable Isotope Center (YASIC)
Our analytical services include measurements of stable and radiocarbon isotopes, cations, anions, greenhouse gases, natural γ-radiation, mercury, and nutrients in water or soil extracts.