Cores Directory

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164 results found

Listing of research core items

  1. Instrument/equipment

    Electron-beam lithography

    For nanoscale patterning, the Raith EBPG 5000+ and EBPG 5200+ electron-beam lithography systems provide 100kV patterning of 10 nm scale devices.

    Located within Yale Institute for Nanoscience and Quantum Engineering (YINQE)

    Sungwoo Sohn, PhD

    Associate Director of Facilities
  2. Services

    Global metabolomics and integrative -omics (intOmics)

    Metabolomics provides screening of targeted (~650) and untargeted (~2500) metabolites.

    Located within Chemical Metabolism Core

    Stephan Siebel, MD, PhD

  3. Instrument/equipment

    Mass spectrometry

    Instruments for mass spectrometry

    Located within West Campus Analytical Core

    Terence Wu

    Director
  4. Instrument/equipment

    Super-resolution and confocal microscopes

    Learn about our Abberior STEDYCON, Andor BC43, Leica SP8, Leica Stellaris 8 Falcon, and Nikon CSU-W1.
     

    Located within West Campus Imaging Core

    Joerg Nikolaus, PhD

    Director
  5. Instrument/equipment

    Light sheet microscope

    Miltenyi UM Blaze is a a user-friendly light sheet microscope designed for subcellular 3D imaging of large and multiple samples.

    Located within West Campus Imaging Core

    Joerg Nikolaus, PhD

    Director
  6. Services
    Two scientists look at a computer screen

    Metabolic flux and enrichment studies using MIMOSA

    In this subcore, parameters of cellular and tissue metabolic flux are assessed by incorporation of stable isotope-labeled tracers (e.g., carbon-13, nitrogen-15, or deuterium) into metabolism. The CMC uses the targeted mass isotopomer multi-ordinate spectral analysis (MIMOSA) platform to interpret stable isotope labeling patterns for calculation of rates of discrete steps in glycolytic and mitochondrial metabolism. Such measurements can be used to identify differences in fuel usage (e.g., glycolysis vs. beta-oxidation), and non-oxidative (reductive carboxylation, anaplerosis and cataplerosis) contributions to the TCA cycle.

    Located within Chemical Metabolism Core

    Stephan Siebel, MD, PhD

  7. Instrument/equipment

    NMR

    Our NMR instruments include a Bruker 400 MHz broadband probe and an Agilent DD2 600 MHz 3 mm cold probe.

    Located within West Campus Analytical Core

    Terence Wu

    Director
  8. Instrument/equipment

    Transmission electron microscopy

    The FEI Tecnai Osiris 200kV TEM is specifically configured for material science.

    Located within Yale Institute for Nanoscience and Quantum Engineering (YINQE)

    Sungwoo Sohn, PhD

  9. Instrument/equipment

    Biotechnology

    Biotechnology instruments

    Located within West Campus Analytical Core

    Terence Wu

    Director
  10. Instrument/equipment

    Other microscopes

    Learn about our Leica DMi8 epifluorescence, Leica Thunder Imager 3D epifluorescence, Leica LMD7000 laser microdissection, and Leica M125 stereo microscopes and Thorlabs optical tweezers system.
     

    Located within West Campus Imaging Core

    Joerg Nikolaus, PhD

    Director
  11. Services

    Quantitative targeted analysis

    Identification and quantification of key metabolites of central carbon metabolism.

    Located within Chemical Metabolism Core

    Stephan Siebel, MD, PhD

  12. Instrument/equipment

    Scanning electron microscopy

    Two Hitachi SU-70 scanning electron microscopes provide 1 nm resolution with a high-brightness electron source.

    Located within Yale Institute for Nanoscience and Quantum Engineering (YINQE)

    Sungwoo Sohn, PhD

    Associate Director of Facilities