Listing of research core items
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Services
Nucleic acid isolation and assessment
DNA/RNA isolation services for a large variety of sample types, including saliva, blood, fresh/frozen or FFPE tissue, and cultured cells.
Located within Keck Microarray Shared ResourcePrimary contact
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Services
Microarray genotyping and gene expression profiling
Traditional microarray services to analyze gene expression pattern, DNA sequence polymorphism (SNPs genotyping), and methylation.
Located within Keck Microarray Shared ResourcePrimary contact
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Services
Single-cell genomics and proteomics analysis: 10x Genomics
Services to study cellular heterogeneity at the single-cell level.
Located within Keck Microarray Shared ResourcePrimary contact
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Services
Single-cell genomics and proteomics analysis: Mission Bio
Mission Bio single-cell DNA and protein analysis
Located within Keck Microarray Shared ResourcePrimary contact
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Services
Single-cell genomics and proteomics analysis: Parse Biosciences
Each cell or nucleus is an individualized reaction compartment.
Located within Keck Microarray Shared ResourcePrimary contact
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Services
Single-cell genomics and proteomics analysis: PhenomeX IsoSpark
The IsoSpark system measures the true function of each cell and identifies the rare subsets of highly functional cells driving response.
Located within Keck Microarray Shared ResourcePrimary contact
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Services
Spatial genomics and proteomics analysis
Next-generation molecular profiling solution for classifying tissue based on total mRNA. Morphological context in spatial transcriptomics and spatial proteomics experiments from one slide.
Located within Keck Microarray Shared ResourcePrimary contact
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Services
Long-read sequencing: Oxford Nanopore
Oxford Nanopore is a long-read sequencing technology that utilizes an ionic current through nanopores and measures the changes in current as biological molecules pass through the nanopore or near it.
Located within Keck Microarray Shared ResourcePrimary contact
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Services
Long-read sequencing: PacBio
The Sequel II System provides the advantages of SMRT sequencing and now makes it more affordable with comprehensive views of genomes and transcriptomes.
Located within Keck Microarray Shared ResourcePrimary contact
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Instrument/equipment
Electron-beam lithography
For nanoscale patterning, the Raith EBPG 5000+ and EBPG 5200+ electron-beam lithography systems provide 100kV patterning of 10 nm scale devices.
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Services
Global metabolomics and integrative -omics (intOmics)
Metabolomics provides screening of targeted (~650) and untargeted (~2500) metabolites.
Located within Chemical Metabolism CoreStephan Siebel, MD, PhD
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Instrument/equipment