Services Core/facility: Keck Oligo Synthesis Resource

RNA & 2'-O-methyl RNA

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About the service

  • We synthesize RNA and 2'-O-methyl RNA only at the 1.0 µmole scale.
  • For RNA oligos longer than 60 bases, we use TOM-protected RNA monomers. For RNA oligos 60 bases or fewer, we use the standard TBDMS-protected RNA monomers.
  • Unless the Cartridge Purification option is selected, we supply all RNA with a 2' protecting group (TOM or TBDMS), which must be removed by the researcher before use. Visit our protocol page for the protocols. We remove all protecting groups from 2'-O-methyl RNA and cartridge-purified RNA.
  • Turnaround times for RNA are typically 5-10 business days.
  • Chimers of DNA/RNA (or 2'-O-methyl RNA) are also available. These orders may be submitted via the Order Modified Oligos page.

Available to Yale researchers & external researchers