Keck Microarray Shared Resource

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Guilin Wang, PhD

Primary contact
Office hours:

Single-cell sample drop-off, 300 George: M–F, 1–4 PM
WC Genome Analysis Ctr, 830 W Campus Dr: M–F, 9 AM–5 PM (After-hours drop-off in foyer)

Building:

300 George Street

About the core

The Keck Microarray Shared Resource (KMSR) functions as a shared cost-recovery core facility to provide technical capability and expertise with state-of-the-art instrumentation for biomedical and clinical research at Yale community as well as institutions around the world. The KSMR is committed to:

  • Providing timely, high-quality data generation and analysis at a competitive cost,
  • Working collaboratively with investigators to develop and implement new technologies for their research, and
  • Educating and training customers in cutting-edge technologies.

Services

 

We provide the following services using state-of-the-art technologies: 

  1. Nucleic acid isolation and assessment
  2. Microarray genotyping and gene expression profiling
  3. Single-cell genomics and proteomics analysis (10X Genomics, Mission Bio, Parse Biosciences, PhenomeX IsoSpark)
  4. Spatial genomics analysis
  5. Long-read sequencing (Oxford Nanopore and PacBio). 

Locations and hours

Single-cell sample drop-off, 300 George Street: Monday – Friday, 1 PM – 4 PM
West Campus Genome Analysis Center, 830 West Campus Drive: Monday – Friday, 9 AM – 5 PM (After-hours sample drop-off in foyer)
 

Terms of service

We will not accept responsibility for ANY samples that fail due to inadequate concentration or quality. ALL CLAIMS, REGARDLESS OF THEIR NATURE, MUST BE BROUGHT TO OUR ATTENTION WITHIN 30 DAYS OF RESULTS DISSEMINATION. The user will only be billed for the work performed. In the event that the sample was found to be the source of processing failure, the user shall bear the resulting cost associated with the troubleshooting. We assume that samples submitted to us have met our posted criteria. Additionally, it is the responsibility of the user to keep track of and use their microarrays and reagents prior to the manufacturers’ expiration date. We will not accept responsibility for array- and reagent expiration-related failures.

Available to Yale researchers & external researchers

Instruments/equipment

  • Keck Microarray instrumentation

    Tools for nucleic acid isolation and assessment, microarray genotyping and gene expression profiling, single-cell genomics and proteomics analysis, spatial genomics analysis, and long-read sequencing.

    Available to Yale researchers & external researchers

Services

Rates

As of 7/1/24:

We will not accept responsibility for ANY samples that fail due to inadequate concentration or quality. ALL CLAIMS, REGARDLESS OF THEIR NATURE, MUST BE BROUGHT TO OUR ATTENTION WITHIN 30 DAYS OF RESULTS DISSEMINATION. The user will only be billed for the work performed. In the event that the sample was found to be the source of processing failure, the user shall bear the resulting cost associated with the troubleshooting. We assume that samples submitted to us have met our posted criteria. Additionally, it is the responsibility of the user to keep track of and use their microarrays and reagents prior to the manufacturers’ expiration date. We will not accept responsibility for array and reagent expiration related failures.

Invoicing and payment

Visit our invoicing and payment page for instructions.

Service fees

Acknowledgment

Please acknowledge Keck Microarray Shared Resource (KMSR) in your publication by including the following statement: “We thank Keck Microarray Shared Resource (KMSR) at Yale University for their assistance with ____________ services."

If you used our PacBio sequencing service, please add the following statement in your publication: “We thank Yale Center for Genome Analysis (YCGA) and Keck Microarray Shared Resource (KMSR) at Yale University for providing the necessary PacBio sequencing services, which are funded in part by the National Institutes of Health instrument grant 1S10OD028669-01.”

If you used our IsoSpark system, please add the following statement in your publication: “We thank Keck Microarray Shared Resource (KMSR) at Yale University for providing the necessary services using the IsoSpark system, which is funded in part by the National Institutes of Health instrument grant 1S10OD034429-01.”

Please always notify us (microarrays@yale.edu) when acknowledgment is made.

Resources

Contacts

Core contacts

Director

Primary contact

Guilin Wang, PhD Research Scientist

Lab Manager

Affymetrix Microarray, PacBio, MissionBio, Nanopore, NanoString, ParseBio

Sok Meng Evelyn Ng Research Associate 3

Research Associate 1

Nucleic acid isolation

Sophia Agostinelli
Person in glasses and a yellow sweater

Associate Staff Scientist

10x single cell sample submission and loading; IsoSpark

Meg Palmatier, PhD

Research Associate 1

10x single-cell library prep

Aidan Kirby
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Research Associate 1

10x Visium spatial and single cell Flex

Christina Rose

Research Associate 1

Illumina Genotyping, 10x single-cell

John Wheeler
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Associate Research Scientist

Genetics

Dejian Zhao, PhD
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Faculty Director

Professor of Genetics

Shrikant Mane, PhD

Contacts

Scientific Advisory Committee

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Spatial genomics technology

Pathology

Rong Fan, PhD Harold Hodgkinson Professor of Biomedical Engineering Professor, Pathology
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Single-cell DNA analysis

Hematology & Pathology

Stephanie Halene, MD, Dr Med Arthur H and Isabel Bunker Professor of Medicine (Hematology) Professor of Pathology
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Single-cell genomics

Microbial Pathogenesis & Infectious Diseases

Ya-Chi Ho Associate Professor
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Long-read sequencing

Molecular Biophysics and Biochemistry & Cell Biology

Karla M Neugebauer, PhD R. Selden Rose Professor of Molecular Biophysics and Biochemistry Professor of Cell Biology
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Single-cell transcriptomic analysis

Neurology & Neuroscience

Le Zhang, PhD Assistant Professor of Neurology and of Neuroscience

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