Yale Center for Molecular Discovery
About the core
Our mission is to provide insight into biological mechanisms and disease targets. We provide expertise in compound and siRNA screening and high-content imaging.
Your Research + YCMD Resources = New Molecules and Biological Insight
The math is simple. Combining your innovative research with YCMD’s resources can jumpstart a new line of inquiry to provide novel tools and biological understanding. Partner with our experienced staff members to find molecules and genes that modify your biology of interest, or investigate in high-throughput format how existing molecules and genetic probes affect the biology. The Center’s resources include small molecule and siRNA collections, sophisticated infrastructure for high-throughput assay design and screening in microplate format, a high-speed fluorescent microscope, and a variety of instrumentation to meet your liquid handling needs.
Services
- Assay design
- Assay development
- High-throughput screening
- High-throughput microscopy and quantitative image analysis
- Medicinal chemistry
- Custom liquid transfers
- Self-service lab
- Support for grant applications and other funding opportunities
- Education and training
- Macromolecular X-ray crystallography core
Instrumentation and libraries
Available to Yale researchers & external researchers
Core website
Contacts
Location (Directions)
Yale West Campus
600 West Campus Drive
West Haven, CT 06516-0972
Mailing address
Yale Center for Molecular Discovery
P.O. Box 27385
West Haven, CT 06516-0972
Shipping address
300 Heffernan Drive
[Recipient Name], MIC Room 110
West Haven, CT 06516
Primary contact
Executive Director
By the numbers
Scientific impact and value added in 2024
- 55 Yale projects, 8 external
- 43 Yale labs, 7 companies, 1 non-Yale lab
- 10 new research publications
79% of projects from Yale School of Medicine; 21% from Faculty of Arts & Sciences
- 20 departments and sections supported
- 33 Yale grant applications supported
- $16M in 13 new grants awarded
- >$126M in grants raised since inception
With future commitments for multi-year grants, YCMD has empowered Yale faculty to secure over $142.4M in funding through 2028.
Successes
- Publication list YCMD has contributed to the following publications.
- Drug Discovery Today Reviews Comprehensive meta-analyses of FDA-approved drugs
- Intellectual property & code of ethics Ethics resources
Publication acknowledgment
If research supported by this research core results in publication, please acknowledge this support by including the following in your publication(s):
“We thank the Yale Center for Molecular Discovery for their assistance with _________ service. The Core is supported in part by an NCI Cancer Center Support Grant # NIH P30 CA016359. Equipment and libraries were supported in part by the Program in Innovative Therapeutics for Connecticut’s Health.”
-
Core/facility
Aberration-Corrected Electron Microscopy (ACEM) Core
Our core's focus is cutting-edge and high-throughput capability in electron microscopy techniques, including TEM, SEM, and FIB.
-
Core/facility
Keck Biophysical Resource
We offer resources to study the oligomeric state of biomolecular assemblies as well as the thermodynamics and kinetics of macromolecular interactions.
-
Core/facility
Yale Center for Genome Analysis (YCGA)
The Yale Center for Genome Analysis is a full-service facility dedicated to providing RNA expression profiling, DNA genotyping, and high-throughput sequencing using state-of-the-art technologies.
Primary contact