Keck Oligo Synthesis Resource
9AM - 5PM
300 George Street, Floor 2, Room 2127
About the core
The Keck Oligonucleotide Synthesis facility carries out DNA and RNA synthesis on our Dr. Oligo 192 and Applied Biosystems 394 synthesizers. We routinely perform a wide variety of complex specialty syntheses, emphasizing quality and efficiency.
Services
- Modifications
- RNA & 2’-O-methyl RNA
- Mixed-base/doped oligos
- Trityl ON oligos
- UltraMild synthesis
- Purification
- Protocols
- 25 nmole service
- Free desalting of normal, un-modified DNA oligos <120 bases synthesized at the 25 and 100 nmole scales
- Large-scale synthesis
Disclaimer
The Keck Oligo Synthesis Section warrants that its products shall conform to the description provided on the product’s accompanying literature or analytical data. ALL PRODUCT CLAIMS, REGARDLESS OF THEIR NATURE, MUST BE BROUGHT TO OUR ATTENTION WITHIN 60 DAYS OF DELIVERY. Due to the highly complex, customized and experimental nature of some modified oligos, we cannot guarantee the purity and yield of all modified products. Although we will do our best to ensure that the highest quality product is achieved, THE KECK OLIGO SECTION SHALL NOT IN ANY EVENT BE LIABLE FOR INCIDENTAL, CONSEQUENTIAL OR SPECIAL DAMAGES OF ANY KIND RESULTING FROM ANY USE OR FAILURE OF THE PRODUCTS NOR SHALL ITS LIABILITY IN ANY CASE EXCEED THE PURCHASE PRICE OF THE PRODUCT.
Available to Yale researchers & external researchers
Core websiteOrdering page
Order hereAcknowledgment
If research supported by this research core results in publication, please acknowledge this support by including the following in your publication(s):
"We thank the Keck Oligo Synthesis Resource at Yale for their assistance with _________ service.”
Rates
Please download this FAQ to learn about our pricing. Learn to order oligos, check order status, and request modifications. Includes synthesized oligo information format, turnaround times, and fee tables. Updated 7-1-24.
Request a quote with this spreadsheet.
FAQ and pricing
Learn to order oligos, check order status, and request modifications. Includes synthesized oligo information format, turnaround times, and fee tables.
Contacts
Staff
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Core/facility
Yale Center for Genome Analysis (YCGA)
The Yale Center for Genome Analysis is a full-service facility dedicated to providing RNA expression profiling, DNA genotyping, and high-throughput sequencing using state-of-the-art technologies.
Primary contact
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Core/facility
Yale Center for Molecular Discovery
We provide resources for assay development and high-throughput screening with small molecules and arrayed siRNA and sgRNA/CRISPR libraries in biochemical, cell-based and image-based assays (primarily 384-well format).
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Core/facility
Chemical Metabolism Core
Previously called the Islet, Oxygen consumption, Mass Isotopomer flux Core (IOMIC), the Chemical Metabolism Core offers targeted and untargeted metabolomics, stable isotope-based metabolic flux analysis, quantitative metabolic panels of central carbon metabolism and adjacent pathways, measurements of cellular bioenergetics, islet isolation and functional studies. Services include study assistance and data analysis.