Cores Directory
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Listing of research core items
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Services
Fragment analysis
Our 3730XL DNA Analyzer uses fluorescence-based detection to determine the size of DNA fragments.
Located within Keck DNA Sequencing Facilitydnaseq@yale.edu
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Core/facility
Yale Genome Editing Center
We create genetically engineered mice via CRISPR/Cas, gene targeting via homologous recombination in ES cells, and traditional transgenic technology. We also cryopreserve mouse sperm and embryos.
Timothy Nottoli, PhD
Primary contact Co-Director Research Scientist in Comparative Medicine -
Services
Human cell line authentication
Using a cell line authentication service can help to establish the identity of a cell line or confirm that it remains uncontaminated. With the use of the CLA Identifiler Direct Kit, we will perform STR genotyping by fragment analysis. This STR profile will be the key to authenticating the cell line.
Located within Keck DNA Sequencing Facilitydnaseq@yale.edu
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Core/facility
Keck Mass Spectrometry & Proteomics Resource
We provide efficient and cost-effective proteomics and state-of-the-art small-molecule mass spectrometry-based services.
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Core/facility
Keck Microarray Shared Resource
Microarray platforms available for high-throughput gene-expression detection.
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Instrument/equipment
Keck Microarray instrumentation
Tools for nucleic acid isolation and assessment, microarray genotyping and gene expression profiling, single-cell genomics and proteomics analysis, spatial genomics analysis, and long-read sequencing.
Located within Keck Microarray Shared ResourcePrimary contact
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Services
Long reads sequencing: Oxford Nanopore
Oxford Nanopore is a long-read sequencing technology that utilizes an ionic current through nanopores and measures the changes in current as biological molecules pass through the nanopore or near it.
Located within Keck Microarray Shared ResourcePrimary contact
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Services
Long reads sequencing: PacBio
The Sequel II System provides the advantages of SMRT sequencing and now makes it more affordable with comprehensive views of genomes and transcriptomes.
Located within Keck Microarray Shared ResourcePrimary contact
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Services
Microarray genotyping and gene expression profiling
Traditional microarray services to analyze gene expression pattern, DNA sequence polymorphism (SNPs genotyping), and methylation.
Located within Keck Microarray Shared Resource -
Core/facility
Molecular and Serological Diagnostics
We test tissues, cells, feces and environmental samples for veterinary viruses, bacteria, parasites, and fungi by polymerase chain reaction (PCR) and reverse transcriptase-PCR (RT-PCR), and mouse and rat sera for viral antibodies.
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Services
Nucleic acid isolation and assessment
DNA/RNA isolation services for a large variety of sample types, including saliva, blood, fresh/frozen or FFPE tissue, and cultured cells.
Located within Keck Microarray Shared ResourcePrimary contact
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Core/facility
Keck Oligo Synthesis Resource
We provide high-quality, timely DNA and RNA synthesis in individual tubes or plates.