Yale Genome Editing Center
We create genetically engineered mice via CRISPR/Cas, gene targeting via homologous recombination in ES cells, and traditional transgenic technology. We also cryopreserve mouse sperm and embryos.
Timothy Nottoli, PhD
Primary contact Co-Director Research Scientist in Comparative MedicineAbout the core
YGEC creates genetically engineered mice via CRISPR/Cas genome editing, gene targeting via homologous recombination in ES cells, and traditional transgenic mouse technology. YGEC also cryopreserves sperm or embryos of inherently valuable genetically altered mouse strains. Assisted reproduction technologies include strain reanimation or rescue via in vitro fertilization and/or embryo transfer. We also offer custom services.
Genome editing for genetically engineered mouse strains includes knockouts, knockins, point mutations, and conditional (floxed) alleles.
Services
Contacts
Primary contact
Project development, genome editing, gene targeting, transgenics
Co-Director
Embryo and sperm manipulation (e.g. microinjection, zygote electroporation, cryopreservation, rederivation, IVF)
Associate Research Scientist
Microinjectionist
Genome editing project development
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Core/Facility
Comparative Pathology Research Core
We offer pathology support for animal-based studies, including histopathology, necropsy, and microbiology as well as assistance with study design.
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Core/Facility
Yale Zebrafish Research Core
The Yale Zebrafish Research Core (YZRC) is a centralized repository of zebrafish services with its own fish facility and experimental space.