Cores Directory

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Listing of research core items

  1. Instrument/equipment

    Flow cytometry cell sorting

    Learn more about cell sorting at Yale Flow Cytometry Facility.

    Located within Yale Flow Cytometry Facility

    Lesley Devine, PhD

    Primary contact
  2. Core/facility
    Image of fluorescently tagged cells

    Yale Center for Molecular Discovery

    We provide resources for assay development and high-throughput screening with small molecules and arrayed siRNA and sgRNA/CRISPR libraries in biochemical, cell-based and image-based assays (primarily 384-well format).

    Yulia Surovtseva, PhD

    Primary contact Director
  3. Core/facility
    Two masked people in white coats point at a screen in a lab

    Chemical Metabolism Core

    Previously called the Islet, Oxygen consumption, Mass Isotopomer flux Core (IOMIC), the Chemical Metabolism Core offers targeted and untargeted metabolomics, stable isotope based metabolic flux analysis, quantitative metabolic panels of central carbon metabolism and adjacent pathways, measurements of cellular bioenergetics,  islet isolation and functional studies. Services include study assistance and data analysis.
     

    Stephan Siebel, MD, PhD

    Primary contact Technical Director
  4. Core/facility
    Wet lab fume hoods

    West Campus Cleanroom

    The cleanroom includes 1200 square feet of wet and dry clean laboratories rated at Class 1000, with features standard to most cleanrooms.

    Lauren McCabe, PhD

    Primary contact Assistant Director, Cleanroom
  5. Core/facility

    Comparative Pathology Research Core

    We offer pathology support for animal-based studies, including histopathology, necropsy, and microbiology as well as assistance with study design.

    Carmen Jane Booth, DVM, PhD

    Primary contact Director
  6. Core/facility
    Microscopic image of tissue at various magnifications

    Confocal Microscopy at CCMI

    We offer confocal microscopy, two-photon microscopy, light-sheet microscopy, swept-field microscopy, super-resolution imaging, and image analysis services.

    Mateus Guerra, PhD

    Primary contact Associate Director
  7. Services

    Genome editing using CRISPR/Cas9 technique

    Gene knockout, single or a few nucleotides replacement and insert reporters in specific locus in hESCs and iPSCs using CRISPR/Cas9 technology.

     

    Located within Human Embryonic/Induced Pluripotent Stem Cell Core

    Caihong Qiu, PhD

    Director
  8. Core/facility

    Yale CryoEM Resource

    The Yale CryoEM Resource comprises electron microscopes on all 3 campuses: a Titan Krios on West Campus, a Glacios and a Tecnai T12 at Yale School of Medicine, and a Glacios and a Talos L120C on Science Hill.

    Jianfeng Lin, PhD

    Primary contact Managing Director
  9. Core/facility
    Person standing before a scientific apparatus

    CyTOF Facility

    The CyTOF 2 facility houses a time-of-flight atomic mass spectrometer for the high-speed acquisition of highly multi-parametric single-cell data.

    Liza Konnikova, MD, PhD

    Primary contact Director
  10. Instrument/equipment
    DSC 250 Zoom In

    Differential scanning calorimetry (DSC)

    This instrument measures the heat flow of materials across phase transitions​. Technical specifications and limits of the equipment are listed below.

    Located within Mechanical and Thermal Analysis Instrumentation Core (MTAIC)

    Amit Datye, PhD

    Primary Contact
  11. Instrument/equipment

    Dry and plasma etching

    Oxford 100 RIE-ICP and Glow Research AutoGlow

    Located within West Campus Cleanroom

    Lauren McCabe, PhD

    Primary contact
  12. Instrument/equipment
    DMA Zoomed Out

    Dynamic mechanical analysis (DMA)

    This instrument measures the dynamic and static deformation of solids in bending and tension.

    Located within Mechanical and Thermal Analysis Instrumentation Core (MTAIC)

    Amit Datye, PhD

    Primary Contact