Cores Directory

Search for the resources you need to answer your research questions.

100 results found

Listing of research core items

  1. Core/facility
    illustration of genetic code with double helix and base symbols

    Yale Center for Genome Analysis (YCGA)

    The Yale Center for Genome Analysis is a full-service facility dedicated to providing RNA expression profiling, DNA genotyping, and high-throughput sequencing using state-of-the-art technologies.

    Primary contact

  2. Core/facility
    Image of fluorescently tagged cells

    Yale Center for Molecular Discovery

    We provide resources for assay development and high-throughput screening with small molecules and arrayed siRNA and sgRNA/CRISPR libraries in biochemical, cell-based and image-based assays (primarily 384-well format).

    Yulia Surovtseva, PhD

    Primary contact Director
  3. Core/facility
    Two masked people in white coats point at a screen in a lab

    Chemical Metabolism Core

    Previously called the Islet, Oxygen consumption, Mass Isotopomer flux Core (IOMIC), the Chemical Metabolism Core offers targeted and untargeted metabolomics, stable isotope based metabolic flux analysis, quantitative metabolic panels of central carbon metabolism and adjacent pathways, measurements of cellular bioenergetics,  islet isolation and functional studies. Services include study assistance and data analysis.
     

    Stephan Siebel, MD, PhD

    Primary contact Technical Director
  4. Instrument/equipment

    Chemical vapor deposition

    The chemical vapor deposition (CVD) tools can deposit metal, oxide, and nitride thin films. The cleanroom offers various CVD tools, including plasma-enhanced CVD and atomic layer deposition.

    Located within Yale University Cleanroom
  5. Core/facility
    Wet lab fume hoods

    West Campus Cleanroom

    The cleanroom includes 1200 square feet of wet and dry clean laboratories rated at Class 1000, with features standard to most cleanrooms.

    Lauren McCabe, PhD

    Primary contact Assistant Director, Cleanroom
  6. Core/facility

    Comparative Pathology Research Core

    We offer pathology support for animal-based studies, including histopathology, necropsy, and microbiology as well as assistance with study design.

    Carmen Jane Booth, DVM, PhD

    Primary contact Director
  7. Core/facility
    Microscopic image of tissue at various magnifications

    Confocal Microscopy at CCMI

    We offer confocal microscopy, two-photon microscopy, light-sheet microscopy, swept-field microscopy, super-resolution imaging, and image analysis services.

    Mateus Guerra, PhD

    Primary contact Associate Director
  8. Services

    Genome editing using CRISPR/Cas9 technique

    Gene knockout, single or a few nucleotides replacement and insert reporters in specific locus in hESCs and iPSCs using CRISPR/Cas9 technology.

     

  9. Core/facility

    Yale CryoEM Resource

    The Yale CryoEM Resource comprises electron microscopes on all 3 campuses: a Titan Krios on West Campus, a Glacios and a Tecnai T12 at Yale School of Medicine, and a Glacios and a Talos L120C on Science Hill.

    Jianfeng Lin, PhD

    Primary contact Managing Director
  10. Core/facility
    Person standing before a scientific apparatus

    CyTOF Facility

    The CyTOF 2 facility houses a time-of-flight atomic mass spectrometer for the high-speed acquisition of highly multi-parametric single-cell data.

    Liza Konnikova, MD, PhD

    Primary contact Director
  11. Core/facility
    Keck DNA Seq

    Keck DNA Sequencing Facility

    Keck DNA Sequencing provides Sanger sequencing and other services, with costs starting as low as $1.99/well and $3.50/tube submission. Sequencing is performed using Thermo Fisher technologies.

    Keck DNA Sequencing

    staff
  12. Services
    Genomic

    DNA/RNA QC analysis service

    QC using the Agilent Tapestation 2200 allows researchers to analyze the quantity and size of DNA or RNA while using only a few microliters of precious sample.