Listing of research core items
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Instrument/equipment
Electron-beam lithography
For nanoscale patterning, the Raith EBPG 5000+ and EBPG 5200+ electron-beam lithography systems provide 100kV patterning of 10 nm scale devices.
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Instrument/equipment
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Services
Metabolic flux and enrichment studies using MIMOSA
In this subcore, parameters of cellular and tissue metabolic flux are assessed by incorporation of stable isotope-labeled tracers (e.g., carbon-13, nitrogen-15, or deuterium) into metabolism. The CMC uses the targeted mass isotopomer multi-ordinate spectral analysis (MIMOSA) platform to interpret stable isotope labeling patterns for calculation of rates of discrete steps in glycolytic and mitochondrial metabolism. Such measurements can be used to identify differences in fuel usage (e.g., glycolysis vs. beta-oxidation), and non-oxidative (reductive carboxylation, anaplerosis and cataplerosis) contributions to the TCA cycle.
Located within Chemical Metabolism CoreStephan Siebel, MD, PhD
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Instrument/equipment
NMR
Our NMR instruments include a Bruker 400 MHz broadband probe and an Agilent DD2 600 MHz 3 mm cold probe.
Located within West Campus Analytical Core -
Instrument/equipment
Transmission electron microscopy
The FEI Tecnai Osiris 200kV TEM is specifically configured for material science.
Sungwoo Sohn, PhD
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Instrument/equipment
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Instrument/equipment
Scanning electron microscopy
Two Hitachi SU-70 scanning electron microscopes provide 1 nm resolution with a high-brightness electron source.
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Instrument/equipment
Atomic force microscopy
A Bruker Dimension Fastscan AFM provides atomic force microscopy in both air and fluids using the new “Peak Force” tapping mode as well as very high speed resonant tapping mode.
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Services
Islet isolation and function
In this subcore, our technical expertise in isolating rodent islets including rats, mice, and most recently ground squirrel from the pancreas ex vivo allows researchers to study the intact islets for their studies or to proceed with substrate-stimulated insulin secretion functional studies using our BioRep Technologies Islet Perfusion Systems (8-channel and 12-channel). For non-rodent islet studies, human donor islet procurement assistance as well as functional studies are also offered.
Located within Chemical Metabolism CoreRebecca Cardone, MS
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Instrument/equipment
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Core/facility
Advanced Instrumentation Development Center (AIDC)
Our mission stands at the nexus between hardware, computing, and data science.
AIDC
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Core/facility
Yale Analytical and Stable Isotope Center (YASIC)
Our analytical services include measurements of stable and radiocarbon isotopes, cations, anions, greenhouse gases, natural γ-radiation, mercury, and nutrients in water or soil extracts.