Cores Directory

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Listing of research core items

  1. Instrument/equipment

    Electron-beam lithography

    For nanoscale patterning, the Raith EBPG 5000+ and EBPG 5200+ electron-beam lithography systems provide 100kV patterning of 10 nm scale devices.

    Located within Yale Institute for Nanoscience and Quantum Engineering (YINQE)

    Sungwoo Sohn, PhD

    Associate Director of Facilities
  2. Services

    Global metabolomics and integrative -omics (intOmics)

    Metabolomics provides screening of targeted (~650) and untargeted (~2500) metabolites. Options for more detailed analyses include volcano plots, pathway enrichment and KEGG network optimization data. Metabolomic data can be integrated with (user provided) RNAseq using a metabolomics network analysis platform (IntOmix), for an optimized pathway analysis of relationships between metabolites and enzyme transcripts.

    Located within Chemical Metabolism Core

    Stephan Siebel, MD, PhD

  3. Instrument/equipment

    Transmission electron microscopy

    The FEI Tecnai Osiris 200kV TEM is specifically configured for material science.

    Located within Yale Institute for Nanoscience and Quantum Engineering (YINQE)

    Sungwoo Sohn, PhD

  4. Services

    Quantitative targeted analysis

    Identification and quantification of key metabolites of central carbon metabolism.

    Located within Chemical Metabolism Core

    Stephan Siebel, MD, PhD

  5. Instrument/equipment

    Scanning electron microscopy

    Two Hitachi SU-70 scanning electron microscopes provide 1 nm resolution with a high-brightness electron source.

    Located within Yale Institute for Nanoscience and Quantum Engineering (YINQE)

    Sungwoo Sohn, PhD

    Associate Director of Facilities
  6. Instrument/equipment

    Atomic force microscopy

    A Bruker Dimension Fastscan AFM provides atomic force microscopy in both air and fluids using the new “Peak Force” tapping mode as well as very high speed resonant tapping mode.

    Located within Yale Institute for Nanoscience and Quantum Engineering (YINQE)

    Sungwoo Sohn, PhD

    Associate Director of Facilities
  7. Services

    Cellular and mitochondrial respiration and bioenergetics

    Cellular and mitochondrial respiration are assessed with the Agilent Seahorse XF Pro. In a 96-well plate format, real-time measurements of cellular respiration, oxidative phosphorylation, mitochondrial leak, and mitochondrial transport are assessed as functional kinetic measurements of cellular bioenergetics. An integrated Agilent BioTek Cytation5 imager correlates cell number to respiration for more accurate normalization of respiration.  

    Located within Chemical Metabolism Core

    Rebecca Cardone, MS

  8. Core/facility

    Aberration-Corrected Electron Microscopy (ACEM) Core

    Our core's focus is cutting-edge and high-throughput capability in electron microscopy techniques, including TEM, SEM, and FIB.

    Primary contact

    Shize Yang, PhD
  9. Core/facility

    Keck Bioinformatics Resource

    The Bioinformatics Resource offers software support; consultation on DNA/protein sequence, microarray, protein structure, and pathway analysis; and collaboration.

    Contact

  10. Core/facility

    Keck Biostatistics Resource

    We offer consultation related to statistical and computational analysis of various types of biological and biomedical data, such as gene expression, genotyping, mass spectrometry, and next-generation sequencing.

    Hongyu Zhao, PhD

    Primary contact Director
  11. Instrument/equipment

    Bruker Luxendo light sheet microscope

    Bruker Luxendo light sheet microscope

    Located within Confocal Microscopy at CCMI

    Mateus Guerra, PhD

    Primary contact Associate Director
  12. Instrument/equipment

    Bruker Opterra II swept-field microscope

    Bruker Opterra II swept-field microscope

    Located within Confocal Microscopy at CCMI

    Mateus Guerra, PhD

    Primary contact Associate Director