Electron Microscopy Facility at CCMI
Sterling Hall of Medicine, suite IE-26
About the core
The core provides a wide range of electron microscopy services. These include sample preparation, standard transmission and scanning electron microscopy for ultrastructure, high-resolution protein localization, and tomographic 3D rendering of the whole cell using focused-ion-beam scanning electron microscopy (FIB-SEM). We work closely with investigators and also train them to use the facility's instruments independently.
Biological electron microscopy services
- Cell and tissue sample processing, embedding in resin for transmission electron microscopy (TEM)
- Ultramicrotomy of plastic sections
- Cryo-sectioning and immuno-gold labeling (Tokuyasu method)
- Immuno-electron microscopy
- Transmission electron microscopy (TEM) and digital imaging
- Scanning electron microscopy (SEM)
- Electron tomography for resin-embedded samples (single/dual tilt series)
- Focused ion beam SEM sample preparation and 3D data collection (FIB-SEM)
- Training on electron microscopes and sample-prep instruments
- Consultation and assistance in experimental design, grant application, and publication
Available to Yale researchers & external researchers
Core websiteContacts
Primary contact
Faculty Director
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