Yale CryoEM Resource

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The Yale CryoEM Resource comprises electron microscopes on all 3 campuses: a Titan Krios on West Campus, a Glacios and a Tecnai T12 at Yale School of Medicine, and a Glacios and a Talos L120C on Science Hill.

Core Website

Jianfeng Lin, PhD

Primary contact Managing Director

About the core

The Yale CryoEM Resource (YCR) is a state-of-the-art cryo electron microscopy (cryoEM) facility. It currently has multiple cryo-sample preparation devices (such as three Vitrobots and a Chameleon) and five electron microscopes (such as a Titan Krios and two Glacios) housed across three Yale campuses.

The YCR provides training, support, and services on cryoEM techniques such as single particle analysis (SPA), cryo electron tomography (cryoET), and microcrystal electron diffraction (MicroED), as well as negative stain EM. It operates as a single functional unit to support the global scientific community, though priority is given to Yale-affiliated researchers.

    Locations and equipment

    YCR at West Campus

    • Titan Krios (West Campus Advanced Biosciences Center, Rm 059F; 840 West Campus Dr.)
    • Vitrobot (West Campus Advanced Biosciences Center, Rm 059C; 840 West Campus Dr.)

    YCR at Yale School of Medicine

    • Tecnai T12 (Sterling Hall of Medicine IE 26; 333 Cedar Street)
    • Glacios (Sterling Hall of Medicine IE 26; 333 Cedar Street)
    • SPT Labtech Chameleon (Sterling Hall of Medicine IE 26; 333 Cedar Street)
    • Vitrobot (Sterling Hall of Medicine IE 26; 333 Cedar Street)

    YCR at Science Hill

    • Talos L120C (Bass Center, Rm 231; 266 Whitney Ave)
    • Glacios (Yale Science Building, Rm C133D; 260 Whitney Ave)
    • Vitrobot (Yale Science Building, Rm C133E; 260 Whitney Ave)

    Contacts

    Managing Director of YCR & Site Director of YCR at Science Hill

    SHIPPING: Jianfeng Lin, Yale Science Building C133, 260 Whitney Ave, New Haven, CT 06511

    Jianfeng Lin, PhD Primary contact

    Site Director of YCR at Yale School of Medicine

    SHIPPING: Marc C. Llaguno, Sterling Hall of Medicine IE 26, 333 Cedar Street, New Haven, CT 06510; SHIPPING (LARGE EQUIPMENT): Marc C. Llaguno, Yale Medical School Receiving, 200 South Frontage Rd., New Haven, CT 06510

    Marc C. Llaguno, PhD

    Site Director of YCR at West Campus

    SHIPPING (INTERNAL): Yale West Campus Advanced Biosciences Center, 840 West Campus Dr. Room 059F, West Haven, CT; SHIPPING (EXTERNAL CARRIERS): Shenping Wu, Yale West Campus Receiving, 300 Heffernan Dr., 840/ABC Room 059F, West Haven, CT 06516

    Shenping Wu, PhD

    Faculty Director

    Frederick Sigworth, PhD

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