Yale CryoEM Resource

About the core

The Yale CryoEM Resource (YCR) is a state-of-the-art cryo electron microscopy (cryoEM) facility. It currently has multiple cryo-sample preparation devices (such as three Vitrobots and a Chameleon) and five electron microscopes (such as a Titan Krios and two Glacios) housed across three Yale campuses.

The YCR provides training, support, and services on cryoEM techniques such as single particle analysis (SPA), cryo electron tomography (cryoET), and microcrystal electron diffraction (MicroED), as well as negative stain EM. It operates as a single functional unit to support the global scientific community, though priority is given to Yale-affiliated researchers.

Locations and equipment

YCR at West Campus

• Titan Krios (West Campus Advanced Biosciences Center, Rm 059F; 840 West Campus Dr.)
• Vitrobot (West Campus Advanced Biosciences Center, Rm 059C; 840 West Campus Dr.)

YCR at Yale School of Medicine

• Tecnai T12 (Sterling Hall of Medicine IE 26; 333 Cedar Street)
• Glacios (Sterling Hall of Medicine IE 26; 333 Cedar Street)
• SPT Labtech Chameleon (Sterling Hall of Medicine IE 26; 333 Cedar Street)
• Vitrobot (Sterling Hall of Medicine IE 26; 333 Cedar Street)

YCR at Science Hill

• Talos L120C (Bass Center, Rm 231; 266 Whitney Ave)
• Glacios (Yale Science Building, Rm C133D; 260 Whitney Ave)
• Vitrobot (Yale Science Building, Rm C133E; 260 Whitney Ave)

Available to Yale researchers & external researchers

• Imaging

Core website