Cores Directory

Search for the resources you need to answer your research questions.

46 results found

Listing of research core items

  1. Services

    Quantitative targeted analysis

    Identification and quantification of key metabolites of central carbon metabolism.

    Located within Chemical Metabolism Core

    Stephan Siebel, MD, PhD

  2. Services
    Two scientists examine a monitor

    Cellular and mitochondrial respiration and bioenergetics

    Cellular and mitochondrial respiration (OCR) and acidification (ECAR) are assessed with the Agilent Seahorse XF Pro 96. In a 96-well plate format, real-time measurements of cellular respiration, oxidative phosphorylation, mitochondrial leak, and mitochondrial transport are assessed as functional kinetic measurements of cellular bioenergetics. Changes in acidification are also observed simultaneously. An integrated Agilent BioTek Cytation5 imager correlates cell number via Hoechst nuclear stain to respiration for more accurate normalization of respiration.

    Located within Chemical Metabolism Core

    Rebecca Cardone, MS

  3. Core/facility

    Advanced Instrumentation Development Center (AIDC)

    Our mission stands at the nexus between hardware, computing, and data science.

    AIDC

  4. Core/facility
    Red light image of a laser

    Advanced Prototyping Center at Wright Lab

    The Advanced Prototyping Center is a fabrication and design support facility to help Yale researchers with custom instrumentation.

    Craig Miller

    Primary contact
  5. Core/facility
    illustration of genetic code with double helix and base symbols

    Yale Center for Genome Analysis (YCGA)

    The Yale Center for Genome Analysis is a full-service facility dedicated to providing RNA expression profiling, DNA genotyping, and high-throughput sequencing using state-of-the-art technologies.

    Primary contact

  6. Core/facility
    Image of fluorescently tagged cells

    Yale Center for Molecular Discovery

    We provide resources for assay development and high-throughput screening with small molecules and arrayed siRNA and sgRNA/CRISPR libraries in biochemical, cell-based and image-based assays (primarily 384-well format).

    Yulia Surovtseva, PhD

    Director
  7. Core/facility
    Two masked people in white coats point at a screen in a lab

    Chemical Metabolism Core

    Previously called the Islet, Oxygen consumption, Mass Isotopomer flux Core (IOMIC), the Chemical Metabolism Core offers targeted and untargeted metabolomics, stable isotope-based metabolic flux analysis, quantitative metabolic panels of central carbon metabolism and adjacent pathways, measurements of cellular bioenergetics,  islet isolation and functional studies. Services include study assistance and data analysis.
     

    Stephan Siebel, MD, PhD

    Technical Director
  8. Core/facility
    Person standing before a scientific apparatus

    CyTOF Facility

    The CyTOF 2 facility houses a time-of-flight atomic mass spectrometer for the high-speed acquisition of highly multi-parametric single-cell data.

    Liza Konnikova, MD, PhD

    Director
  9. Core/facility

    Yale University Cytogenetics Laboratory

    The core provides testing for cancer predisposition, metabolic and developmental disorders.

  10. Core/facility
    Keck DNA Seq

    Keck DNA Sequencing Facility

    Keck DNA Sequencing provides Sanger sequencing and other services, with costs starting as low as $2.22/well and $4.00/tube submission. Sequencing is performed using Thermo Fisher technologies.

    Keck DNA Sequencing

    staff
  11. Services
    Genomic

    DNA/RNA QC analysis service

    QC using the Agilent Tapestation 2200 allows researchers to analyze the quantity and size of DNA or RNA while using only a few microliters of precious sample.

  12. Core/facility
    Custom titanium mini dual slider alongside a quarter for scale

    YSM Electronic & Machine Shop

    We offer custom design, fabrication, and repair services at the Yale School of Medicine as well as tools for loan. We build prototype devices for medical research.

    Anthony DeSimone

    Director