Cores Directory

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Listing of research core items

  1. Services

    Nucleic acid isolation and assessment

    DNA/RNA isolation services for a large variety of sample types, including saliva, blood, fresh/frozen or FFPE tissue, and cultured cells.

    Located within Keck Microarray Shared Resource

    Primary contact

  2. Services

    Microarray genotyping and gene expression profiling

    Traditional microarray services to analyze gene expression pattern, DNA sequence polymorphism (SNPs genotyping), and methylation.

    Located within Keck Microarray Shared Resource

    Primary contact

  3. Services

    Single-cell genomics and proteomics analysis

    Learn about 10X Genomics, Parse Biosciences, and PhenomeX Isospark technologies.

    Located within Keck Microarray Shared Resource

    Primary contact

  4. Services

    Spatial genomics and proteomics analysis

    Next-generation molecular profiling solution for classifying tissue based on total mRNA. Morphological context in spatial transcriptomics and spatial proteomics experiments from one slide. 10x Genomics Visium and Nanostring GeoMX.

    Located within Keck Microarray Shared Resource

    Primary contact

  5. Services

    Long-read sequencing

    Solutions from Oxford Nanopore and PacBio. 

    Located within Keck Microarray Shared Resource

    Primary contact

  6. Services

    Global metabolomics and integrative -omics (intOmics)

    Metabolomics provides screening of targeted (~650) and untargeted (~2500) metabolites.

    Located within Chemical Metabolism Core

    Stephan Siebel, MD, PhD

  7. Services

    Quantitative targeted analysis

    Identification and quantification of key metabolites of central carbon metabolism.

    Located within Chemical Metabolism Core

    Stephan Siebel, MD, PhD

  8. Services
    Two scientists examine a monitor

    Cellular and mitochondrial respiration and bioenergetics

    Cellular and mitochondrial respiration (OCR) and acidification (ECAR) are assessed with the Agilent Seahorse XF Pro 96. In a 96-well plate format, real-time measurements of cellular respiration, oxidative phosphorylation, mitochondrial leak, and mitochondrial transport are assessed as functional kinetic measurements of cellular bioenergetics. Changes in acidification are also observed simultaneously. An integrated Agilent BioTek Cytation5 imager correlates cell number via Hoechst nuclear stain to respiration for more accurate normalization of respiration.

    Located within Chemical Metabolism Core

    Rebecca Cardone, MS

  9. Instrument/equipment
    Cell Analyzer

    Invitrogen Attune NXT Cell Analyzer

    Analyze cells from tubes and plates with 4 lasers (violet, blue, yellow/green, red) and 14 detectors (6 violet, 2 blue, 3 yellow, 3 red).

    Located within West Campus Flow Cytometry Facility

    Fiona Hall Fenteany

    WCFC Director
  10. Core/facility

    Keck Bioinformatics Resource

    The Bioinformatics Resource offers software support; consultation on DNA/protein sequence, microarray, protein structure, and pathway analysis; and collaboration.

    Contact

  11. Core/facility

    Keck Biophysical Resource

    We offer resources to study the oligomeric state of biomolecular assemblies as well as the thermodynamics and kinetics of macromolecular interactions.

    Ewa Folta-Stogniew, PhD, MSc

    Primary contact Director
  12. Core/facility

    Keck Biostatistics Resource

    We offer consultation related to statistical and computational analysis of various types of biological and biomedical data, such as gene expression, genotyping, mass spectrometry, and next-generation sequencing.

    Hongyu Zhao, PhD

    Primary contact Director