Structural Science Facility

Instrument location: KCL 7
Date of acquisition: October 2016

The Pilatus3R 200KA detector on our Rigaku 007 HF+ rotating anode with VHF Arc)Sec optics is suitable for solving small molecules samples. This instrument is run by the CBIC Staff. λ = 0.7107 Å

Instrument location: KCL 7
Date of acquisition: October 2009

The Saturn 944+ CCD detector on our Rigaku 007 HF+ rotating anode X-ray source with HF optics is suitable for solving small-molecule and protein structures by single-crystal X-ray diffraction. This instrument can also be used to screen crystals before sending them to an x-ray beam line at a synchrotron. λ = 1.5418 Å

Instrument location: KCL 7
Date of acquisition: June 2016

The Rigaku Saturn 944HG CCD detector on our Rigaku 007 HF+ rotating anode X-ray source with HF Arc)Sec optics is suitable for solving small molecules samples. This instrument is run by the CBIC Staff. λ = 1.5418 Å

Instrument location: KCL 7
Date of acquisition: December 2004

This powder diffractometer can characterize crystallinity, crystal phases, and, in many cases, the identity of solid samples. Our instrument has a sealed-tube copper X-ray source, a scintillation counter with high dynamic range, and Bragg-Brentano geometry with slits providing high resolution for flat powder samples. λ = 1.5418 Å

Instrument location: KCL 7
Date of acquisition: May 2022

The XtaLabMini II is a fully functional benchtop single-crystal X-ray diffractometer with a CCD detector. λ = 0.7107 Å

Instrument location: KCL 7
Date of acquisition: January 2023

Copper and silver X-ray sources are available. The curved image plate detector allows high dynamic range and collection out to a 2Θ angle of 144 degrees in a single image to yield high-resolution single-crystal data.

Instrument location: KCL 7
Date of acquisition: October 2009

TTP Labtech’s mosquito allows for the creation of protein crystallization screens with several multi-component drops per well, even in 96-well hanging drop set-ups.

Instrument location: SCL 26
Date of acquisition: December 2022

The Xeuss 3.0 offers a maximum flexibility of measurement configurations to get the best possible data quality on any type of sample. In particular, the following key features enable the user to optimize experiments or results:

• High flux settings adapted for fast kinetics embedded in a low background camera
• Largest surface of detection moveable all the way from WAXS to long-distance SAXS to optimize resolution and signal-to-noise
• Long distance SAXS settings for measuring large characteristic dimensions (up to 900 nm depending on the Xeuss 3.0 model)
• Optional USAXS module to characterize large structures ( >2.5 µm)

Instrument location: SCL 26
Date of acquisition: May 2018

Micro-CT is a 3D imaging technique utilizing X-rays to see inside an object, slice by slice. Micro-CT, also called microtomography or micro computed tomography, is similar to hospital CT or “CAT” scan imaging but on a small scale with greatly increased resolution. Samples can be imaged with pixel sizes as small as ~1 micron and objects can be scanned up to ~50 cm in diameter.

The versatile XT H 225 scanner can be used to cover a wide range of applications, including the inspection of plastic parts, electronics and complex mechanisms as well as researching materials and natural specimens.

The scanner can be fitted with a rotating anode, reflection, or transmission target. The rotating anode produces the most X-rays, which is good for highly absorbing material, but has the lowest resolution. The transmission target has the best resolution, but produces the least amount of X-rays. The reflection target is typically installed and has a balance between X-ray intensity and resolution. If you need the rotating or transmission target, please inquire in advance about scheduling.

The Synergy-ED is a state-of-the-art electron diffractometer designed for Microcrystal Electron Diffraction (MicroED) / 3D Electron Diffraction (3DED) experiments. It enables high-resolution structural analysis of nanocrystalline materials that are too small for conventional X-ray diffraction techniques.

Key Features
Wavelength:
Operates at an electron wavelength of ~0.0251 Å with a 200 kV accelerating voltage, providing high-resolution diffraction data.
Temperature Range:
Capable of measuring samples from room temperature down to 100 K, allowing for studies of temperature-dependent structural changes.
Viable Grain Size:
Suitable for nanocrystals and microcrystals ranging from several hundred nanometers to less than 10 microns.
Sample Types
The Synergy-ED is optimized for a broad range of crystalline materials, including:
-Small organic molecules (e.g., pharmaceuticals, natural products)
-Inorganic nanomaterials
-Metal-organic frameworks (MOFs) and zeolites
-Peptides and small proteins
-Polymers and hybrid materials
Applications
Pharmaceutical Research:
Polymorph Studies: Determines different crystal forms of a compound, crucial for drug formulation and stability.
Phase Transitions: Investigates temperature- or pressure-induced structural changes.
Materials Science & Nanotechnology:
Grain Boundary Analysis: Characterizes defects, interfaces, and grain orientations in polycrystalline materials.
Nanocrystalline and Amorphous Phase Identification: Helps differentiate between ordered and disordered structures.
Heterogeneous Sample Analysis:
Sample Mixtures: Can resolve and identify multiple crystalline phases within complex mixtures.
Solid-State Chemistry: Provides insight into phase purity and composition.