Cores Directory

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Listing of research core items

  1. Services

    Nucleic acid isolation and assessment

    DNA/RNA isolation services for a large variety of sample types, including saliva, blood, fresh/frozen or FFPE tissue, and cultured cells.

    Located within Keck Microarray Shared Resource

    Primary contact

  2. Services

    Microarray genotyping and gene expression profiling

    Traditional microarray services to analyze gene expression pattern, DNA sequence polymorphism (SNPs genotyping), and methylation.

    Located within Keck Microarray Shared Resource

    Primary contact

  3. Services

    Single-cell genomics and proteomics analysis: 10x Genomics

    Services to study cellular heterogeneity at the single-cell level.

    Located within Keck Microarray Shared Resource

    Primary contact

  4. Services

    Single-cell genomics and proteomics analysis: Mission Bio

    Mission Bio single-cell DNA and protein analysis

    Located within Keck Microarray Shared Resource

    Primary contact

  5. Services

    Single-cell genomics and proteomics analysis: Parse Biosciences

    Each cell or nucleus is an individualized reaction compartment.

    Located within Keck Microarray Shared Resource

    Primary contact

  6. Services

    Single-cell genomics and proteomics analysis: PhenomeX IsoSpark

    The IsoSpark system measures the true function of each cell and identifies the rare subsets of highly functional cells driving response.

    Located within Keck Microarray Shared Resource

    Primary contact

  7. Services

    Spatial genomics and proteomics analysis

    Next-generation molecular profiling solution for classifying tissue based on total mRNA. Morphological context in spatial transcriptomics and spatial proteomics experiments from one slide.

    Located within Keck Microarray Shared Resource

    Primary contact

  8. Services

    Long-read sequencing: Oxford Nanopore

    Oxford Nanopore is a long-read sequencing technology that utilizes an ionic current through nanopores and measures the changes in current as biological molecules pass through the nanopore or near it.

    Located within Keck Microarray Shared Resource

    Primary contact

  9. Services

    Long-read sequencing: PacBio

    The Sequel II System provides the advantages of SMRT sequencing and now makes it more affordable with comprehensive views of genomes and transcriptomes.

    Located within Keck Microarray Shared Resource

    Primary contact

  10. Services

    Global metabolomics and integrative -omics (intOmics)

    Metabolomics provides screening of targeted (~650) and untargeted (~2500) metabolites.

    Located within Chemical Metabolism Core

    Stephan Siebel, MD, PhD

  11. Services

    Quantitative targeted analysis

    Identification and quantification of key metabolites of central carbon metabolism.

    Located within Chemical Metabolism Core

    Stephan Siebel, MD, PhD

  12. Services
    Two scientists examine a monitor

    Cellular and mitochondrial respiration and bioenergetics

    Cellular and mitochondrial respiration (OCR) and acidification (ECAR) are assessed with the Agilent Seahorse XF Pro 96. In a 96-well plate format, real-time measurements of cellular respiration, oxidative phosphorylation, mitochondrial leak, and mitochondrial transport are assessed as functional kinetic measurements of cellular bioenergetics. Changes in acidification are also observed simultaneously. An integrated Agilent BioTek Cytation5 imager correlates cell number via Hoechst nuclear stain to respiration for more accurate normalization of respiration.

    Located within Chemical Metabolism Core

    Rebecca Cardone, MS