Yale Center for Molecular Discovery

Research Cores Directory
Yale Center for Molecular Discovery

Yulia Surovtseva, PhD

Director

Building: 600 West Campus Dr; see Contacts

About the core

Our mission is to provide insight into biological mechanisms and disease targets. We provide expertise in compound and siRNA screening and high-content imaging. Partnering with the Yale Center for Molecular Discovery (YCMD) Shared Resource can accelerate new lines of inquiry by providing novel tools, actionable insights, and biological understanding. Our experienced staff work collaboratively with investigators to discover molecules and genes that modulate pathways of interest and to evaluate, at scale, how existing chemical and genetic probes influence relevant biology. This core is one of eight shared resources that supports research at Yale Cancer Center, as well as science across Yale University.

View all Yale Cancer Center Shared Resources

Our resources include small molecule and siRNA collections, sophisticated infrastructure for high-throughput assay design and screening in microplate format, a high-speed fluorescent microscope, and a variety of instrumentation to meet your plate reading and liquid handling needs.

We provide genome-wide sgRNA/CRISPR screening for therapeutic pathway and target discovery, chemical screening and medicinal chemistry support for lead discovery and development, and development and execution of statistically robust, often highly customized high-throughput assay platforms to support testing and screening.

Your Research + YCMD Resources = New Molecules and Biological Insight

The math is simple. Combining your innovative research with YCMD’s resources can jump-start a new line of inquiry to provide novel tools and biological understanding. Partner with our experienced staff members to find molecules and genes that modify your biology of interest, or investigate in high-throughput format how existing molecules and genetic probes affect the biology.

Available to Yale researchers & external researchers

By the numbers

Statistics about scientific impact and value added

Scientific impact and value added in 2024

55 Yale projects, 8 external
43 Yale labs, 7 companies, 1 non-Yale lab
10 new research publications

79% of projects from Yale School of Medicine; 21% from Faculty of Arts & Sciences

20 departments and sections supported
33 Yale grant applications supported
$16M in 13 new grants awarded
>$126M in grants raised since inception

With future commitments for multi-year grants, YCMD has empowered Yale faculty to secure over $142.4M in funding through 2028.

Successes

Publication list YCMD has contributed to the following publications.
Drug Discovery Today Reviews Comprehensive meta-analyses of FDA-approved drugs
Intellectual property & code of ethics Ethics resources

Education, training, and more

Publication acknowledgment

If research supported by this research core results in publication, please acknowledge this support by including the following in your publication(s):

“We thank the Yale Center for Molecular Discovery for their assistance with _________ service. The Core is supported in part by an NCI Cancer Center Support Grant # NIH P30 CA016359. Equipment and libraries were supported in part by the Program in Innovative Therapeutics for Connecticut’s Health.”