Keck Biophysical Resource
Ewa Folta-Stogniew, PhD, MSc
Director (Retired)Building: 300 George St, rm 2131
About the core
Dr. Folta-Stogniew retired on December 31, 2025. The Keck Biophysical Resource will no longer be available for services except for NIDA investigators, who will still have access to all below listed technologies.
The Biophysical Resource is a core operated by Keck Foundation Biotechnology Resource Laboratory at Yale University. We currently have resources to study the oligomeric state of biomolecular assemblies as well as the thermodynamics and kinetics of macromolecular interactions using:
- Nanoparticle tracking analysis (NTA) has been moved to PPMS for the CyTOF Facility, AC-S416, 300 Cedar Street. Please contact Huanxing Sun for further information.
- Dynamic light scattering detector (DLS) has been moved to PPMS for the CyTOF Facility, AC-S416, 300 Cedar Street. Please contact Huanxing Sun for further information.
- Multiangle laser light scattering detector and dynamic light scattering detector (MALLS and DLS)
- Isothermal microcalorimetry (ITC)
- Surface plasmon resonance - BiaCore biosensor (SPR)
- Spectrofluorometer: PTI-QuantaMaster
- Asymmetric flow field-flow fractionation
- Fluorescence plate reader
- CD - spectrophotometer
Available to Yale researchers & external researchers
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Core/facility
Yale Center for Molecular Discovery
We provide resources for assay development and high-throughput screening with small molecules and arrayed siRNA and sgRNA/CRISPR libraries in biochemical, cell-based and image-based assays (primarily 384-well format).
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Core/facility
Chemical Metabolism Core
Previously called the Islet, Oxygen consumption, Mass Isotopomer flux Core (IOMIC), the Chemical Metabolism Core offers targeted and untargeted metabolomics, stable isotope-based metabolic flux analysis, quantitative metabolic panels of central carbon metabolism and adjacent pathways, measurements of cellular bioenergetics, islet isolation and functional studies. Services include study assistance and data analysis.
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Core/facility
Comparative Pathology Research Core
We offer pathology support for animal-based studies, including histopathology, necropsy, and microbiology, as well as assistance with study design.