Precision Cancer Modeling
About the core
Advancing drug discovery research through preclinical modeling
The Precision Cancer Modeling (PCM) Center enables high-quality, hypothesis-driven preclinical studies that accelerate drug discovery and translational research. We partner with academic and industry investigators to design and execute scientifically rigorous in vivo studies that generate reliable, publication-ready data and support regulatory submissions.
PCM maintains a diverse portfolio of well-characterized and custom-designed cancer models that are continuously validated and maintained in a ready-to-use state. These models support evaluation of experimental therapeutics in both monotherapy and combination settings, enabling efficient testing of innovative treatment strategies.
Our comprehensive pharmacology capabilities include toxicology (Tox), pharmacokinetics (PK), and pharmacodynamics (PD) studies, with experimental designs tailored to the specific scientific objectives of each project. PCM functions as a collaborative research partner, supporting grant-funded research, high-impact publications, and translational advancement.
PCM also provides training and access to advanced small-animal imaging resources at the Medical School and West Campuses. Imaging platforms include bioluminescence, fluorescence, and X-ray–enabled IVIS systems, as well as high-resolution MRI, enabling noninvasive, longitudinal assessment of disease progression and therapeutic response.
Availability differs per offering
Core websiteGetting started
PCM is excited to start using an online system to streamline the process of ordering and billing for core service requests. All facility users are invited to use the system, which requires a one-time registration. Once you are registered, the system will enable you to request consultations, schedule equipment time, provide required approvals, and monitor progress.
Learn moreRepository
Our repository includes a diverse collection of human and murine cell lines, the majority of which have been tested and confirmed pathogen-free and are suitable for engraftment as xenografts or syngeneic allografts in appropriate mouse hosts. View a spreadsheet of our available cell line models.
We also maintain a collection of uncultured human and murine tumor specimens suitable for explant culture and in vivo propagation, including patient-derived xenograft (PDX) models. Please contact us to discuss potential applications for your preclinical research.
Contacts
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Core/facility
Aberration-Corrected Electron Microscopy (ACEM) Core
Our core's focus is cutting-edge and high-throughput capability in electron microscopy techniques, including TEM, SEM, and FIB.
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Core/facility
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Core/facility
Yale Center for Molecular Discovery
We provide resources for assay development and high-throughput screening with small molecules and arrayed siRNA and sgRNA/CRISPR libraries in biochemical, cell-based and image-based assays (primarily 384-well format).