FIB-SEM Collaboration Core (F-SCC)

We utilize unparalleled enhanced FIB-SEM pipeline to generate large-volume three-dimensional electron microscopy data with nanometer isotropic resolution. Such data reveal critical insights about structure-function relationships in biology.

Core Website

Song Pang

Director Primary contact
Hours & Location

Sterling Hall of Medicine B-wing, 333 Cedar Street, room E10

About the core

At the forefront of volume electron microscopy (EM), we welcome your collaboration to take discoveries in biology, physiology, and pathology to a whole new level using our proprietary enhanced FIB-SEM (eFIB-SEM) technology and its unparalleled pipeline. This enhanced FIB-SEM technology enables 3D large-volume high-resolution imaging, capable of years of continuous imaging without defects in the final image stack.


  • EM sample preparation with TEM evaluation
  • Non-destructive 3D X-ray tomography
  • X-ray guided eFIB-SEM sample preparation to define, reposition, and refine region of interest (ROI)
  • 3D large-volume isotropic high-resolution eFIB-SEM imaging
  • eFIB-SEM image registration and alignment
  • eFIB-SEM data segmentation and analysis (to be announced)


Physical address:


333 Cedar Street

New Haven, CT 06510


Postal address (USPS):

P.O. Box 208026

333 Cedar Street

New Haven CT 06520-8026


Shipping address (FedEx and UPS):

c/o Cellular & Molecular Physiology Department


200 South Frontage Rd

New Haven, CT 06510

Primary contact

Song Pang Director

Faculty Director

C. Shan Xu, PhD Harvey and Kate Cushing Professor of Cellular & Molecular Physiology