Cores Directory
Search for the resources you need to answer your research questions.
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Listing of research core items
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Instrument/equipment
Plate readers and detection methods
Tools include the Molecular Devices FLIPR, BMG Labtech PHERAStar, and the Biotek Synergy Neo2. Learn about available detection methods as well.
Located within Yale Center for Molecular DiscoveryYulia Surovtseva
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Services
High-throughput microscopy & quantitative image analysis
Multicolor fluorescent image-based assays, plus developing an algorithm, processing images, and analyzing the results.
Located within Yale Center for Molecular DiscoveryYulia Surovtseva
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Instrument/equipment
Liquid handlers
Options for liquid handling.
Located within Yale Center for Molecular DiscoveryYulia Surovtseva
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Services
Custom liquid transfers
Volumes as low as nanoliters can be plated precisely where you want them.
Located within Yale Center for Molecular DiscoveryYulia Surovtseva
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Services
Single-cell genomics and proteomics analysis
Learn about 10X Genomics, Parse Biosciences, and Bruker Isospark technologies.
Located within Keck Microarray Shared ResourcePrimary contact
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Services
Self-service lab
The lab provides access to screening equipment as a lower-cost option to advance assay development and screening.
Located within Yale Center for Molecular DiscoveryYulia Surovtseva
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Services
Spatial genomics and proteomics analysis
Next-generation molecular profiling solution for classifying tissue based on total mRNA. Morphological context in spatial transcriptomics and spatial proteomics experiments from one slide. 10x Genomics Visium and Nanostring GeoMx.
Located within Keck Microarray Shared ResourcePrimary contact
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Services
Grant support
Collaborate on design and wording of aims for optimal success.
Located within Yale Center for Molecular DiscoveryYulia Surovtseva
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Services
Long-read sequencing
Solutions from Oxford Nanopore and PacBio.
Located within Keck Microarray Shared ResourcePrimary contact
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Services
Global metabolomics and integrative -omics (intOmics)
Metabolomics provides screening of targeted (~650) and untargeted (~2500) metabolites.
Located within Chemical Metabolism CoreStephan Siebel, MD, PhD
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Services
Quantitative targeted analysis
Identification and quantification of key metabolites of central carbon metabolism.
Located within Chemical Metabolism CoreStephan Siebel, MD, PhD
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Services
Cellular and mitochondrial respiration and bioenergetics
Cellular and mitochondrial respiration (OCR) and acidification (ECAR) are assessed with the Agilent Seahorse XF Pro 96. In a 96-well plate format, real-time measurements of cellular respiration, oxidative phosphorylation, mitochondrial leak, and mitochondrial transport are assessed as functional kinetic measurements of cellular bioenergetics. Changes in acidification are also observed simultaneously. An integrated Agilent BioTek Cytation5 imager correlates cell number via Hoechst nuclear stain to respiration for more accurate normalization of respiration.
Located within Chemical Metabolism CoreRebecca Cardone, MS