Macromolecular Structure Analysis Consultation
Bass Center for Molecular and Structural Biology, room 341
About the core
Dr. Jimin Wang is an expert in developing new methods for quantitative analysis of experimental charge density maps and electrostatic potential maps and in analyzing molecular dynamics trajectories and other large-scale structural analysis.
Dr. Wang has recently developed very sensitive methods to detect subtle changes in cryo-EM maps associated with effects of single-amino acid substitutions in proteins, binding of small ligands to proteins, or charge changes in metalloenzymes at relatively low resolution even when the identity of amino acids could not be recognized.
He is available to perform and/or advise on many software packages to generate publication-quality illustrations of high-resolution macromolecular structures, analysis of X-ray crystallography and cryo-EM data. Some spectroscopic data analysis is also available.
Available to Yale researchers only
Contacts
Primary contact
Faculty Director
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Core/facility
Aberration-Corrected Electron Microscopy (ACEM) Core
Our core's focus is cutting-edge and high-throughput capability in electron microscopy techniques, including TEM, SEM, and FIB.
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Core/facility
Yale Center for Molecular Discovery
We provide resources for assay development and high-throughput screening with small molecules and arrayed siRNA and sgRNA/CRISPR libraries in biochemical, cell-based and image-based assays (primarily 384-well format).
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Core/facility
West Campus Cleanroom
The cleanroom includes 1200 square feet of wet and dry clean laboratories rated at Class 1000, with features standard to most cleanrooms.
Lauren McCabe, PhD
Primary contact Assistant Director, Cleanroom