Jasco Semi-Prep SFC-MS System

The semi-prep SFC has capacity for larger-scale purification, but it can still be used for analytical scale method development. The autosampler accommodates 20 ml vials in 40 well plates. It is configured with an Advion-expression mass detector to allow two-dimensional analysis of complex chiral and achiral mixtures. The stacked injection setup allows multiple injections in a single sequence. The open-bed fraction collector can be triggered on time, threshold, or slope based on signals from 2 different detectors' signals including UV and/or MS. The macro cyclone separators provide simple gas-liquid separation in the fraction bottle for fraction recoveries typically greater than 95%.

Semi-prep features

Using supercritical carbon-dioxide and a co-solvent (methanol, isopropanol), this system offers rapid analysis and isolation. Fitted with three 1-cm columns that are:

• Water Torus 2-PIC achiral column
• Waters Torus 1-AA achiral column
• Chiral Technologies IC immobilized column

More information about these columns and their uses can be found here.