The Chemical and Biophysical Instrumentation Center (CBIC) offers NMR spectroscopy, X-ray crystallography, mass spectrometry, and other instruments to characterize and structurally elucidate chemical and biophysical samples.

Core Website

Eric Paulson, PhD

Primary contact Director
Hours & Location

Chemistry Research Building, room 100; Kline Chemistry Laboratory, rooms 3, 6, 7, and 8

About the core

The Chemical and Biophysical Instrumentation Center (CBIC) was born in 2009 of the merger of Yale’s Chemical and Biophysical Instrument Centers (the CIC and BIC). We are most equipped in the areas of NMR spectroscopy and X-ray crystallography, but we also feature resources in mass spectrometry, optical instrumentation, and calorimetry. Explore our full instrument catalog or request an account.


  • 500wb Bruker Neo 500 MHz NMR spectrometer
  • A400a Agilent DD2 400 MHz NMR spectrometer (autosampler)
  • A400b Agilent DD2 400 MHz NMR spectrometer (manual)
  • A400c Agilent DD2 400 MHz NMR spectrometer (autosampler)
  • A500a Agilent DD2 500 MHz NMR spectrometer (manual)
  • A500b Agilent DD2 500 MHz NMR spectrometer (manual)
  • A600a Agilent DD2 600 MHz NMR spectrometer (autosampler)
  • A800 Agilent 800 MHz NMR spectrometer (manual)
  • Analytical ultracentrifuge Beckman Coulter Proteomelab XL-I
  • Applied Photophysics Chirascan Circular Dichroism spectrometer
  • DLS Dynamic Light Scattering Wyatt DynaPro PlateReader II
  • EPR Bruker EleXsys EPR spectrometer
  • FTIR ASI React IR reaction-monitoring system
  • FTIR Shimadzu IRTracer-100
  • FTIR/Raman Thermo Nicolet 6700
  • GC-MS Agilent 6890N/5973
  • GC-MS column selection
  • GC-TQ-MS Shimadzu 8050 NX
  • LC-MS Shimadzu 8060 TQ
  • LC-MS Shimadzu 9030 Quadrupole Time-of-Flight MS
  • LC-MS ThermoScientific QExactive Orbitrap (+ IR spectroscopy)
  • LC-MS Waters Xevo Qtof high-resolution MS
  • MALDI-ToF-MS Shimadzu AXIMA Confidence
  • Mass spectrometry meets infrared spectroscopy
  • MS recommendations, method descriptions, and software
  • Pilatus3R HPC on a 007 VHF+Arc)Sec X-ray source
  • Polarimeter Perkin Elmer 341
  • Polarimeter Rudolph Autopol IV
  • Rigaku CCD on 007HF+ X-ray source
  • Rigaku CCD on 007HF+Arc)Sec X-ray source
  • Rigaku MiniFlex600 powder X-ray diffractometer
  • Rigaku XtaLAB Mini II with a hybrid pixel detector
  • Rigaku XtaLAB Synergy, Dualflex, HyPix-Arc 100
  • TA NanoITC
  • TCSPC TD-Fluor Horiba Fluorolog 3 Time Domain fluorimeter
  • TTP Lab-tech nanoliter pipetting system
  • UV-VIS Cary 3E spectrophotometer
  • UV-VIS Shimadzu UV-3600Plus
  • V600a Varian VNMRS 600 MHz NMR spectrometer (Manual)
  • V600b Varian VNMRS 600 MHz NMR spectrometer (Manual)
  • V700 Varian Inova 700 MHz NMR spectrometer (Manual)
  • Xenocs Xeuss 3.0 small/wide X-ray scattering system
  • XT H 225 computed tomography scanner

Getting started at CBIC

Video training


Physical address (map):

CRB 100 and KCL 3, 6, 7, 8

275 Prospect St.

New Haven, CT


Postal address:

P.O. Box 208107

New Haven, CT 06520-8107


Shipping address:

Chemical & Biophysical Instrumentation Center

Yale University Chemistry Department

350 Edwards St.

New Haven, CT 06511

Primary contact

Eric Paulson, PhD Director

X-Ray Crystallographer

Mass Spectrometrist

Instrument Support Specialist

NMR Spectroscopist

Robert Berry, PhD

Faculty Director

J. Patrick Loria Professor of Chemistry and of Molecular Biophysics and Biochemistry