LifeCanvas SmartSPIM Light Sheet Microscope

The instrument is intended for imaging large cleared specimens, such as organoids, whole brains, and other internal organs of small mammals. The system can accommodate samples with a maximum lateral dimension of 40 mm x 65 mm. It can also be used for imaging expanded samples and, in certain applications, live specimens where ultra-high acquisition speed and environmental control are not required.

Key features include:

• 445, 488, 561, and 642 nm lasers
• 1.6×, 3.6×, and 9× objectives with numerical apertures (NA) of 0.1, 0.2, and 0.3, respectively. 
• Resolution: 1 to 3 µm depending on the objective used.

• Speed and data size: higher resolution results in increased acquisition time and larger data volumes. For reference, imaging an entire mouse brain with the 3.6× objective typically takes approximately one hour and generates about 150 GB of data per fluorescence channel.