Keck Mass Spec & Proteomics: Publications
Browse publications arising from research at Keck Mass Spectrometry & Proteomics Resource.
2020 to present
260. Vidyadhara, D.J., Somayaji, M., Wade, N., Yücel, B., Zhao, H., Ribaudo, J., Shashaank N., Gupta, J., Lam, T., Sames, D., Greene, L.E., Sulzer, D., Chandra, S.S. (2023) Dopamine transporter and synaptic vesicle sorting defects initiate auxilin-mediated Parkinson’s Disease. Cell Reports 42(3): 112231 (PMCID: PMC10127800).
259. Shi, G., Song, C., Robles, J., Salichos, L., Lou, H., Lam, T.T., Gerstein, M.,Turk, B.E. (2023) Proteome-wide screening for mitogen-activated protein kinase docking motifs and interactors. Science Signaling 16 (767), eabm5518 (PMCID: PMC9995140).
258. Robert, S., Reeves, B., Kiziltug, E., Duy, P., Karimy, J., Mansuri, M., Marlier, A., Allington, G., Greenberg, A., DeSpenza, T., Singh, A., Zeng, X., Mekbib, K., Kundishora,.,Nelson-Williams, C., Zhang, J., Lam, T.T., Wilson, R., Butler, W., Diluna, M., Feinberg, P., Schafer, D., Movahedi, K., Tannenbaum, A., Koundal, S., Chen, X., Benveniste, H., Limbrick, D., Schiff, S., Carter, B., Gunel, M., Simard, J., Lifton, R.P., Alper, S., Delpire, E., Kahle, K.T. (2023) The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus. Cell 186(4): 764-785 (PMID: 36803604, PMCID: PMC10069664 available on 2024-02-16).
257. Onuchic, L., Padovano, V., Schena, G., Rajendran, V., Dong, K., Shi, X., Pandya, R., Rai, V., Gresko, N., Ahmed, O., Lam, T.T., Wang, W., Shen, H., Somlo, S., Caplan, M.J. (2023) The C-terminal tail of polycystin-1 suppresses cystic disease in a mitochondrial enzyme-dependent fashion. Nature Communications 14(1):1790 (PMCID: PMC10063565).
256. Misra, S., Khan, E., Lam, T. T., Mazumder, R., Gururangan, K., Hickman, L. B., Goswami, V., Funaro, M. C., Eldem, E., Sansing, L. H., Sico, J. J., Quinn, T. J., Liebeskind, D., Montaner, J., Kwan, P., Mishra, N. K. (2023) The common pathways of Epileptogenesis in patients With Epilepsy Post-Brain Injury: Findings from a systematic review and meta-analysis. Neurology, online ahead of print (PMID: 37550071)
255. Maynard, G., Kannan, R., Liu, J., Wang, W., Lam, T. T., Wang, X., Adamson, C., Hackett, C., Schwab, J. M., Liu, C., Leslie, D. P., Chen, D., Marino, R., Zafonte, R., Flanders, A., Block, G., Smith, E., Strittmatter, S. M. (2023) Soluble Nogo-Receptor-Fc decoy (AXER-204) in patients with chronic cervical spinal cord injury in the USA: a first-in-human and randomized clinical trial. Lancet Neurol. 22 (8), 672-684 (PMID: 37479373, PMCID: PMC10410101 (available on 2024-08-01)).
254. Martin-Lopez, E., Vidyadhara, D.J., Liberia, T., Meller, S. J., Harmon, L.E., Hsu, R.M., Han, K., Betül Yücel, B., Chandra, S.S. and Greer, C.A. (2023). Alpha-Synuclein pathology and reduced neurogenesis in the olfactory system affect olfaction in a mouse model of Parkinson's Disease. J. Neurosci. 43(6): 1051-1071 (Cover article, PMCID: PMC9908323).
253. Malla, A., Yu, H., Farris, D., Kadimi, S., Lam, T.T., Cox, A., Smith, Z., Lesch, B. (2023) DOT1L bridges transcription and heterochromatin formation at mammalian pericentromeres. EMBO Reports e56492 online ahead of print (PMID: 37317657, PMCID: PMC10398668 (available on 2024-06-15)).
252. Ketchesin, K.D., Becker-Krail, D.D., Xue, X., Wilson, R.S., Lam, T.T., Williams, K.R., Nairn, A.C., Tseng, G.C., Logan, R.W. (2023) Differential effects of cocaine and morphine on the diurnal regulation of the mouse nucleus accumbens proteome. J. Proteome Res. 22(7): 2377-2390 (PMCID: PMC10392613).
251. Ganesh, S. Lam, T.K., Garcia-Milian, R., D’Souza, D., Nairn, A.C., Elgert, K., Eitan, E., Ranganathan, M. (2023) Peripheral signature of altered synaptic integrity in young onset Cannabis Use Disorder: A proteomic study of circulating extracellular vesicles. World J. Biol. Psychiatry 2023 Apr 13;1-11. doi: 10.1080/15622975.2023.2197039. Online ahead of print. (PMID: 36994633).
250. Droit, A., Pelletier, S., Leclerq, M., Roux-Dalvai, F., de Geus, M., Leslie, S., Wang, W., Lam, T., Nairn, A.C., Arnold, S., Carlyle, B., Precioso, F., (2023) Enhancing classification of liquid chromatography mass spectrometry data with Batch Effect Removal Neural Networks (BERNN). Res. Sq. Preprint (PMCID: PMC10350225).
249. de Geus, M. B., Leslie, S. N., Lam, T., Wang, W., Kivisakk, P., Nairn, A. C., Arnold, S. E., Carlyle, B. C. (2023) Mass spectrometry in cerebrospinal fluid uncovers association of glycolysis biomarkers with Alzheimer's Disease in a Large Clinical Sample. Res. Sq. Preprint (PMCID: PMC10350182).
248. Zhang, M., Berk JM, Mehrtash AB, Kanyo J, Hochstrasser M. (2022) A versatile new tool derived from a bacterial deubiquitylase to detect and purify ubiquitylated substrates and their interacting proteins. PLoS Biol. 20(6):e3001501 (PMCID: PMC9278747).
247. Yang, M., Horstman, S., Gee, R., Guyer, P., Lam, T.T., Kanyo, J., Perdigoto, A., Speake, C., Greenbaum, C., Callebaut, A., Overbergh, L., Kibbey, R., Herold, K., James, E., Mamula, M.J. (2022) Citrullination of glucokinase is linked to autoimmune diabetes. Nature Commun. 13: 1870 (PMCID: PMC8986778).
246. Yang, M., Connolly, S., Gee, R., Lam,T.T., Kanyo, J., Peng, J., Guyer, P., Syed, F., Tse, H., Clarke, S., Clarke, C., James, E., Speake, C., Evans-Molina, C., Arvan, P., Herold, K., Wen, L., Mamula, M., (2022) Carbonyl posttranslational modification associated with Early-Onset Type 1 Diabetes Autoimmunity. Diabetes 71 (9), 1979-1993 (PMID: 35730902, PMCID: PMC9450849 available on 2023-09-01).
245. Wang, Y., Chen, Y., Garcia-Milian, R., Golla, J., Charkoftaki, G., Lam, T.T., Thompson, D., Vasiliou, V. (2022) Proteomic profiling reveals an association between ALDH and oxidative phosphorylation and DNA damage repair pathways in human colon adenocarcinoma stem cells. Chemico-Biological Interactions 368: 110175 (PMCID: PMC9891852).
244. Verreault, M., Segoviano Vilchis, I., Rosenberg, S., Lemaire, N., Schmitt, C., Guehennec, J., Royer-Perron, L., Thomas, J., Lam, T.T., Dingli, F., Loew, D., Ducray, F., Paris, S., Carpentier, C., Marie, Y., Laigle-Donadey, F., Rousseau, A., Pigat, N., Boutillon, F., Bielle, F., Mokhtari, K., Frank, S., de Reyniès, A., Hoang-Xuan, K., Sanson, M., Goffin, V., Idbaih, A. (2022) Identification of growth hormone receptor as a relevant target for precision medicine in low-EGFR expressing glioblastoma. Clin. Transl. Med. 12(7) (PMCID: PMC9270581).
243. Shin, N., Marlier, A., Xu, L., Lam, T.T., Cantley, L.G., Guo, J.K. (2022) Characterization of temporospatial distribution of renal tubular casts by nephron tracking after ischemia-reperfusion injury. Am. J. Physiol. Renal Physiol. 322(3):F322-F334 (PMCID: PMC8897010).
242. Saland, S., Wilczak, K., Voss, E., Lam, T.T., Kabbaj, M. (2022) Sex-and estrous-cycle dependent dorsal hippocampal phosphoproteomic changes induced by low-dose ketamine. Scientific Reports 12(1): 1820 (PMCID: PMC8810966).
241. Kandigian, S., Ethier, E., Kitchen, R., Lam, T.T., Arnold, S., Carlyle, B. (2022) Proteomic characterization of post-mortem human brain tissue following ultracentrifugation-based subcellular fractionation Brain Commun. 4(3): fcac103 (PMCID: PMC9123841).
240. Jurkowitz, M., Azad, A., Monsma, P., Keiser, T., Kanyo, J., Lam, T.T., Bell, C., Schlesinger, L. (2022) Mycobacterium tuberculosis encodes a YhhN family membrane protein with lysoplasmalogenase activity that protects against toxic host lysolipids. J. Biol. Chem. 298(5):101849 (PMCID: PMC9052158).
239. Jarrold, B., Tan, C., Ho, C., Soon, A., Lam, T.T., Yang, X., Nguyen, C., Guo, W., Chew, Y., DeAngelis, Y., Costello, L., De Los Santos Gomez, P., Przyborski, S., Bellanger, S., Dreesen, O., Kimball, A., Oblong, J. (2022) Early onset of senescence and imbalanced epidermal homeostasis across the decades in photoexposed human skin: Fingerprints of inflammaging. Exp. Dermatol. 31(11):1748-1760 (PMID: 36320153).
238. Griffin, K., Walters, B., Li, H., Wang, H., Biancon, G., Tebaldi, T., Kaya, C., Kanyo, J., Lam, T.T., Cox, A., Halene, S., Chung, J., Lesch, B. (2022) Widespread association of the Argonaute protein AGO2 with meiotic chromatin suggests a distinct nuclear function in mammalian male reproduction. Genome Research 32(9): 1655-1668 (PMCID: PMC9528986).
237. Gorenberg, E., Tieze, S., Yucel, B., Zhao, H., Bishai, J., Chou, V., Wirak, G., Tomita, S., Lam, T.T., Chandra, S.S. (2022) Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function. PLoS Biol. 20(3): e3001590 (Cover article, PMCID: PMC9004782).
236. Falahati, H., Wu, Y., Feuerer, V., Simon, H., De Camilli P. (2022) Proximity proteomics of synaptopodin provides insight into the molecular composition of the spine apparatus of dendritic spines. Proc. Natl. Acad. Sci. 119(42): e2203750119 (PMCID: PMC9586327).
235. Brody, A., Nies, S., Guan, F., Smith, L., Mukherjee, B., Salazar, S., Lee, S. Lam, T.T., Strittmatter, S. (2022). Alzheimer risk gene product Pyk2 suppresses Tau phosphorylation and phenotypic effects of tauopathy. Mol. Neurodegeneration 17(1): 32 (PMCID: PMC9063299).
234. Blackburn, J., Jamwal, S., Wang, W., Elsworth, J. (2022) Pioglitazone transiently stimulates paraoxonase-2 expression in male nonhuman primate brain: Implications for sex-specific therapeutics in neurodegenerative disorders. Neurochem. Int.152:105222 (PMCID: PMC8712400).
233. Bircher, J., Corcoran, E., Lam, T.T., Trnka, M., Koleske, A.J. (2022) Autoinhibition of the GEF activity of cytoskeletal regulatory protein Trio is disrupted in neurodevelopmental disorder-related genetic variants. J. Biol. Chem. 298(9): 102361 (PMCID: PMC9467883).
232. Sitapara, R., Lam, T.T., Gandjeva, A., Tuder, R., Zisman, L. (2021) Phosphoproteomic analysis of lung tissue from patients with pulmonary arterial hypertension. Pulmonary Circulation. 11(3) 20458940211031109 (PMCID: PMC8711668).
231. Leslie, S., Kanyo, J. Datta, D., Wilson, R., Zeiss, C., Duque, A., Lam, T.T., Arnsten, A., Nairn, A.C. (2021) Simple, single-shot phosphoproteomic analysis of heat-stable Tau identifies age-related changes in pS235-and pS396-Tau levels in non-human primates. Frontiers in Aging Neuroscience 13: 767322 (PMCID: PMC8637411).
230. Ahsan, N., Rao, R., Wilson, R., Punyamurtula, U., Salvato, F., Petersen, M., Ahmed, M., Abid, M., Verburgt, J., Kihara, D., Yang, Z., Fornelli, L., Foster, S., Ramratnam, B. (2021) Mass spectrometry-based proteomic platforms for better understanding of SARS-CoV-2 induced pathogenesis and potential diagnostic approaches. Proteomics 21(10): e2000279 (PMCID: PMC8250252).
229. Zhang, L., Lin, T. V., Yuan, Q., Sadoul, R., Lam, T. T.,Bordey, A. (2021) Small Extracellular Vesicles Control Dendritic Spine Development through Regulation of HDAC2 signaling. J. Neurosci. 41 (17): 3799-3807(PMCID: PMC8084316).
228. Odom, C. V., Kim, Y., Burgess, C. L., Baird, L. A., Korkmaz, F. T., Na, E., Shenoy, A. T., Arafa, E. I., Lam, T. T., Jones, M. R., Mizgerd, J. P., Traber, K. E.,Quinton, L. J. (2021) Liver-Dependent lung remodeling during systemic inflammation shapes responses to secondary infection. J. Immunol. 207(7): 1891-1902 (PMCID: PMC8631467).
227. López, A. J., Johnson, A. R., Euston, T. J., Wilson, R., Nolan, S. O., Brady, L. J., Thibeault, K. C., Kelly, S. J., Kondev, V., Melugin, P., Kutlu, M. G., Chuang, E., Lam, T. T., Kiraly, D. D., Calipari, E. S. (2021)Cocaine self-administration induces sex-dependent protein expression in the nucleus accumbens. Commun. Biol. 4(1): 883 (PMCID: PMC8285523).
226. Lee, A. M., Mansuri, M. S., Wilson, R. S., Lam, T. T., Nairn, A. C., Picciotto, M. R. (2021) Sex differences in the ventral tegmental area and nucleus accumbens proteome at baseline and following nicotine exposure. Front. Mol. Neurosci. 14: 657064 (PMCID: PMC8317211).
225. Hofford, R. S., Euston, T. J., Wilson, R. S., Meckel, K. R., Peck, E. G., Godino, A., Landry, J. A., Calipari, E. S., Lam, T. T.,Kiraly, D. D. (2021) Granulocyte-Colony Stimulating Factor reduces cocaine-seeking and downregulates glutamatergic synaptic proteins in medial prefrontal cortex. J. Neurosci. 41(7): 1553-1565 (PMCID: PMC7896012).
224. Ahsan, N., Wilson, R., Rao, R., Salvato, F., Sabila, M., Ullah, H, Miernyk, J. (2020) Mass Spectrometry-Based identification of Phospho-Tyr in plant proteomics. J. Proteome Res.19(2):561-571 (PMID: 31967836).
223. Taguchi, Y.V., Gorenberg, E.L., Nagy, M., Thrasher, D., Fenton, W.A., Volpicelli-Daley, L., Horwich, A.L., Chandra, S.S., (2020) Hsp110 mitigates a-synuclein pathology in vivo. Proc. Natl. Acad. Sci. U.S.A. 116(48): 24310-24316 (PMCID: PMC6883785).
222. Ryu, C., Walia, A., Ortiz, V., Perry, C., Woo,S., Reeves, B.C. Sun, H., Winkler, J., Kanyo, J.E., Wang, W., Vukmirovic, M., Ristic, N., Stratton, E.A., Meena, S.R., Minasyan, M., Kurbanov, D., Liu, X., Lam, T.T., Farina, G., Gomez, J.l., Gulati, M., Herzog, E.L. (2020) Bioactive plasma mitochondrial DNA is associated with disease progression in scleroderma associated interstitial lung disease. Arthritis & Rheumatology 72(11): 1905-1915 (PMCID: PMC8081728).
221. Piersigilli, F., Syed, M., Lam, T. T., Dotta, A., Massoud, M., Vernocchi, P., Quagliariello, A., Putignani, L., Auriti, C., Salvatori, G., Bagolan, P., Bhandari, V. (2020) An omic approach to congenital diaphragmatic hernia: a pilot study of genomic, microRNA, and metabolomic profiling. J. Perinatol. 40 (6), 952-961, (PMID: 32080334).
220. Nakamura, Y., Morrow, D.H., Nathanson, A.J., Henley, J.M., Wilkinson, K.A., Moss, S.J. (2020) Phosphorylation on Ser-359 of the a2 subunit in GABA type A receptors down-regulates their density at inhibitory synapses. J. Biol. Chem. 295(35), 12330-12342, (JBC Editor’s Pick Publication, PMCID: PMC7458806).
219. Mansuri, M., Peng, G.,.Wilson, R., Lam, T., Zhao, H., Williams, K., Nairn, A. (2020) Differential Protein Expression in Striatal D1- and D2-Dopamine Receptor-expressing Medium Spiny Neurons. Proteomes 8(4) 27, (PMCID: PMC7709116).
218. Li, X., Terunuma, M., Deeb, T.G., Wiseman, S., Pangalos, M.N., Nairn, A.C., Moss, S.J., Slesinger, P.A. (2020) Direct interaction of PP2A phosphatase with GABAB receptors alters functional signaling. J. Neurosci. 40(14), 2808-2816, (PMCID: PMC7117905).
217. Kandyliari, A.,Mallouchos, A., Papandroulakis, N., Golla, J.P., Lam, T.T., Sakellari, A., Karavoltsos, S., Vasiliou, V., Kapsokefalou, M. (2020) Nutrient composition and fatty acid and protein profiles of selected fish by-products Foods 9(2), 190, (PMCID: PMC7074476).
216. Franzen, A.,Lam, T.,Williams, K., Nairn, A., Duman, R.,Sathyanesan, M.,Kumar, V., Carpenter, L.,Sathyanesan, S. (2020) Cerebrospinal fluid proteome evaluation in major depressive disorder by mass spectrometry. BMC Psychiatry 20(1), 481, (PMCID: PMC7528485).
215. Chen, M., Sun, H., Boot, M., Shao, L., Chang, S.J., Wang, W., Lam, T.T., Lara-Tejero, M., Rego, E.H., Galán, J.E. (2020) Itaconate is an effector of a Rab GTPase cell-autonomous host defense pathway against Salmonella. Science 369(6502), 450-455, (PMCID: PMC8020367).
214. Ahsan, M.K., Figueroa-Hall, L., Baratta, V., Garcia-Milian, R., Lam, T.T., Hoque, K., Salas, P.J., Ameen, N.A. (2020) Glucocorticoids and serum-and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea. American Journal of Physiology-Gastrointestinal and Liver Physiology 319(2), G121-G132, (PMCID: PMC7500270).
2010 to 2019
213. Xue, M., Kim, C. S., Healy, A. R., Wernke, K. M., Wang, Z., Frischling, M. C., Shine, E. E., Wang, W., Herzon, S. B., Crawford, J. M. (2019) Structure elucidation of colibactin and its DNA cross-links. Science 365 (6457), (PCMID: PMC6820679).
212. Wilson, R. Rauniyar, N., Sakaue, F., Lam, T.K.T., Williams, K., Nairn, A. (2019) Development of targeted mass spectrometry-based approaches for quantitation of proteins enriched in the postsynaptic density (PSD), Proteomes Special Issue on Neuroproteomics 7(2), (PMCID:PMC6630806).
211. Torregrossa, M., MacDonald, M., Stone, K.L., Lam, T.K.T., Nairn, A.C., Taylor, J.R. (2019) Phosphoproteomic analysis of cocaine memory extinction and reconsolidation in the nucleus accumbens, Psychopharmacology 236(1), 531-543, (PMCID:PMC6374162).
210. Piersigilli, F., Lam, T. T., Vernocchi, P., Quagliariello, A., Putignani, L., Aghai, Z. H., Bhandari, V., (2019) Identification of new biomarkers of bronchopulmonary dysplasia using metabolomics. Metabolomics 15 (2), 20, (PMID: 30830433).
209. Peng, G., Wilson, R., Tang, Y., Lam, T. T., Nairn, A. C., Williams, K., Zhao, H. (2019) ProteomicsBrowser: MS/proteomics data visualization and investigation. Bioinformatics 35 (13), 2313-2314, (PCMID: PMC6596887).
208. Nassar, A. F., Wisnewski, A. V., Wu, T., Lam, T. T., King, I. Development and Validation of LC-MS-MS Assay for the Determination of the Emerging Alkylating Agent Laromustine and Its Active Metabolite in Human Plasma (2019) J. Chromatogr. Sci. 57 (3), 195-203, (PMID: 30395213).
207. Li, J., Walsh, A., Lam, T.K.T., Delecluse, H.J., El-Guindy, A. (2019) A single phosphoacceptor residue in BGLF3 is essential for transcription of Epstein-Barr virus late genes. PLoS pathogens 15(8), e1007980, (PMCID: PMC6713331).
206. Kiapour, A.M., Sieker, J.T., Proffen, B.L., Lam, T.K.T., Fleming, B.C., Murray, M.M. (2019) Synovial fluid proteome changes in ACL injury-induced posttraumatic osteoarthritis: Proteomics analysis of porcine knee synovial fluid. PloS One 14(3), e0212662, (PMCID: PMC6396923).
205. Ghosh, D., Egbuta, C., Kanyo, J.E., Lam, T.K.T.(2019) Phosphorylation of human placental aromatase CYP19A1. Biochemical Journal 476(21), 3313-3331, (PMCID: PMC7069221).
204. Farasyn, T., Crowe, A., Hatley, O., Neuhoff, S., Alam, K., Kanyo, J., Lam, T.K.T., Ding, K., Yue, W. (2019).Preincubation with everolimus and sirolimus reduces organic anion-transporting polypeptide (OATP) 1B1-and 1B3-mediated transport independently of mTOR kinase inhibition: Implication in Assessing OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions. Journal of Pharmaceutical Sciences 108(1), 3443-3456, (PMCID: PMC6759397).
203. Charkoftaki, G., Thompson, D.C., Golla, J.P., Garcia-Milian, R., Lam, T.T., Engel, J.,Vasilou, V. (2019) Integrated multi-omics approach reveals a role of ALDH1A1 in lipid metabolism in human colon cancer cells. Chemico-biological Interactions 304, 88-96, (PMCID: PMC7988342).
202. Rauniyar, N., Yu, X. Cantley, J., Voss, E.Z., Belcher, J., Colangelo, C.M., Stone, K.L., Dahl, N., Parikh, C., Lam, T.T., Cantley, L.G. (2018) Quantification of urinary protein biomarkers of autosomal dominant polycystic kidney disease by parallel reaction monitoring. Proteomics Clin. Appl. 12(5), e1700157, (PMCID: PMC6736530).
201. Rao, V., Zavala, G., Roy, A., Mains, R., Eipper, B. (2018) A pH-sensitive luminal His-cluster promotes interaction of PAM with V-ATPase along the secretory and endocytic pathways of peptidergic cells. J. Cellular Physiology 234(6), 8683-8697, (PMCID: PMC6395498).
200. Miller, M.B., Wilson, R.S., Lam, T.T., Nairn, A. C., Picciotto, M.R. (2018) Evaluation of the phosphoproteome of mouse alpha 4/beta 2-containing nicotinic acetylcholine receptors in vitro and in vivo. Proteomes 6(4), 42, (PMCID: PMC6313896).
199. Mervosh, N., Wilson, R., Rauniyar, N., Hofford, R., Kutlu, M., Calipari, E., Lam, T. T., Kiraly, D., (2018) Granulocyte-colony stimulating factor alters the proteomic landscape of the ventral tegmental area. Proteomes Special Issue on Neuroproteomics 6(4), 35, (PMCID: PMC6313867).
198. Luxmi, R., Blaby-Haas, C., Kumar, D., Rauniyar, N., King, S., Mains, R., Eipper, B. (2018) Proteases shape the Chlamydomonas secretome: Comparison to classical neuropeptide processing machinery. Proteomes Special Issue on Neuroproteomics 6(4), 36 (PMCID: PMC6313938).
197. Li, D., Musante, V., Zhou, W., Picciotto, M.R., Nairn, A.C. (2018) Striatin-1 is a B subunit of protein phosphatase PP2A that regulates dendritic arborization and spine development in striatal neurons. J. Biol. Chem. 293(28),11179-11194 (PMCID: PMC6052221).
196. Goel, R.K., Meyer, M., Paczkowska, M., Reimand, J., Vizeacoumar,F., Lam, T.K., Lukong, K.E. (2018) Global phosphoproteomic analysis identifies SRMS-regulated secondary signaling intermediates. Proteome Science 16(1),16 (PMCID: PMC6098843).
195. Cijsouw, T., Ramsey, A., Lam, T., Carbone, B., Blanpied, T., Biederer, T. (2018) Mapping the proteome of the synaptic cleft through proximity labeling reveals new cleft proteins. Proteomes Special Issue on Neuroproteomics 6(4), 48 (PMCID: PMC6313906).
194. Carlyle, B.C., Kitchen, R.R., Zhang, J., Wilson, R., Lam, T.T., Rozowsky, J.S., Williams, K., Sestan, N., Gerstein, M.B., Nairn, A.C. (2018) Isoform level interpretation of high-throughput proteomic data enabled by deep integration with RNA-seq. J. Proteome Research 17(10), 3431-3444, (PMCID:PMC6392456).
193. Bian, X., Saheki, Y., and De Camilli, P. (2018) Ca2+ releases E-Syt1 autoinhibition to couple ER-plasma membrane tethering with lipid transport. EMBO J. 37(2), 219-234 (PMCID: PMC5770786),
192. Bertholomey, M.L., Stone, K.L., Lam, T.T., Bang, S., Wu, W., Nairn, A.C., Taylor, J.R., Torregrossa, M.M. (2018) Phosphoproteomic analysis of the amygdala response to adolescent glucocorticoid exposure reveals G-protein coupled receptor kinase 2 (GRK2) as a target for reducing motivation for alcohol. Proteomes Special Issue on Neuroproteomics 6(4), 41, (PMCID: PMC6313880).
191. Yuan, Q., Ren, C., Xu, W., Petri, B., Zhang, J., Zhang, Y., Kubes, P., Wu, D., Tang, W. (2017) PKN1 Directs Polarized RAB21 Vesicle Trafficking via RPH3A and Is Important for Neutrophil Adhesion and Ischemia-Reperfusion Injury. Cell Reports 19, 2586-2597. (PMCID: PMC5548392).
190. Williams, K., Colangelo, C., Hou, L., Chung, L., Belcher, J., Abbott, T., Hall, I., Zhao, H., Cantley, J., Parikh, C. (2017) Use of a Targeted Urine Proteome Assay (TUPA) to Identify Protein Biomarkers of Delayed Recovery After Kidney Transplant. Proteomics Clinical Applications 11, 7-8, (PMCID: PMC5549272).
189. Srivastava, R., Mannam, P., Rauniyar, N., Lam, T.K.T., Luo, R., Lee, P.J., Srivastava, A. (2017) Proteomics data on MAP Kinase Kinase 3 knock out bone marrow derived macrophages exposed to cigarette smoke extract. Data in Brief 13, 320-325, (PMCID: PMC5476452).
188. Rauniyar, N., Peng, G., Lam, T., Zhao, H., Mor, G., Williams, K., (2017) Data-Independent Acquisition (DIA) and Parallel Reaction Monitoring (PRM) Mass Spectrometry Identification of Serum Biomarkers for Ovarian Cancer. Biomarkers Insight 12, 1-12, (PMCID: PMC5462478).
187. Musante, V., Li L., Kanyo, J., Lam, T.T., Colangelo, C.M., Cheng, S.K., Brody, H., Greengard, P., Le Novère N., Nairn, A.C. (2017) Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition. eLife 6, e24998, (PMCID:PMC5515580).
186. Miller, M.B., Yan, Y., Machida, K., Kiraly, D.D., Levy, A.D., Wu, Y.I., Lam, T.T., Abbott, T., Koleske, A.J., Eipper, B.A., Mains, R.E. (2017) Brain region and isoform-specific phosphorylation alters Kalirin SH2 domain interaction sites and calpain sensitivity, ACS Chemical Neuroscience 8, 1554-1569, (PMCID: PMC5517348).
185. Li, X., Tao, Y., Murphy, J.W., Scherer, A.N., Lam, T.K.T., Marshall, A.G., Koleske, A.J., Boggon, T.J. (2017) The repeat region of cortactin is intrinsically disordered in solution. Scientific reports 7(1), 1-10, (PMCID: PMC5711941).
184. Janostiak, R., Rauniyar, N., Lam, T.K.T., Ou, J., Zhu, L.J., Green, M.R., Wajapeyee, N. (2017) MELK promotes melanoma growth by stimulating the NF-?B pathway. Cell Reports 21(10), 2829-2841, (PMCID: PMC5726781).
183. Goffredo, M., Santoro, N.,Tricò, D., Giannini, C., D’Adamo, E., Zhao, H., Peng, G., Yu, X., Lam, T.K.T., Pierpont, B., Caprio, S., Herzog, R. (2017) A branched-chain amino acid-related metabolic signature characterizes obese adolescents with non-alcoholic fatty liver disease. Nutrients 9(7), 642 (PMCID: PMC5537762).
182. Glass, L.N., Swapna, G., Chavadi, S.S.,Tufariello, J.A.M.,Mi, K., Drumm, J.E., Lam, T.K.T., Zhu, G., Zhan, C., Vilchéze, C., Arcos, J., Chen, Y., Bi, L., Mehta S., Porcelli, S.A., Almo, S.C., Yeh, S., Jacobs, W.R.,Torrelles J.B., Chan, J., (2017) Mycobacterium tuberculosis universal stress protein Rv2623 interacts with the putative ATP binding cassette (APC) transporter Rv1747 to regulate mycobacterial growth. PLoS pathogens 13(7), e1006515, (https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006515)
181. Carlyle, B., Kitchen, R., Kanyo J., Voss, E., Pletikos, M., Lam, T. T., Gerstein, M., Sestan, N., Nairn, A.C. (2017) A multiregional proteomic survey of the postnatal human brain, Nature Neuroscience 20, 1787-1795, (PMCID: PMC5894337).
180. Andrade, E.C., Musante, V., Horiuchi, A., Matsuzaki, H., Harrison, A., Brody, H., Wu, T., Greengard, P., Taylor, J.R. and Nairn, A.C. (2017) ARPP-16 is a striatal-enriched inhibitor of protein phosphatase 2A regulated by microtubule-associated serine/threonine kinase 3 (Mast 3 kinase). J. Neurosci. 37(10), 2709-2722 (PMCID: PMC5354324)
179. Vishwanatha, K.S., Back, N., Lam, T.K.T., Mains, R.E., Eipper, B.A. (2016) O-Glycosylation of a Secretory Granule Membrane Enzyme Is Essential for Its Endocytic Trafficking. J. Biol. Chem. 291(18), 9835-50. (PMCID: PMC4850319).
178. Rich, M.T., Abbott, T., Chung, L., Gulcicek E.E., Stone, K.L., Colangelo, C.M., Lam, T.T., Nairn, A.C., Taylor, J.R., Torregrossa, M.M. (2016) Phosphoproteomic analysis reveals a novel mechanism of CAMKIIa regulation inversely induced by cocaine memory extinction versus reconsolidation. J. Neuroscience 36(29),7613-27, (PMCID: PMC4951572).
177. McClure-Begley, T. D., Esterlis, I., Stone, K. L., Lam, T. T., Grady, S.R., Colangelo, C.M., Lindstrom, J.M., Marks, M.J., and Picciotto, M.R. (2016) Evaluation of the Nicotinic Acetylcholine Receptor-Associated Proteome at Baseline and Following Nicotine Exposure in Human and Mouse Cortex. eNeuro 3, (PMCID: PMC4985585).
176. Henderson, M.X., Wirak, G.S., Zhang, Y., Dai, F., Ginsberg, S.D., Dolzhanskaya, N., Staropoli, J.F., Nijssen, P.C.G., Lam, TuKiet T., Roth, A.F., Davis, N.G., Dawson, G., Velinov, M., Chandra, S.S., (2016) Neuronal ceroid lipofuscinosis with DNAJC5/CSPalpha mutation has PPT1 pathology and exhibit aberrant protein palmitoylation. Acta Neuropathologics 131(4), 621-37 (PMCID: PMC4791186).
175. Fleming, M.R., Brown, M.R., Kronengold, J., Zhang, Y., Jenkins, D.P., Barcia, G., Nabbout, R., Bausch, A.E., Ruth, P., Lukowski, R., Navaratnam, D.S. and Kaczmarek, L.K. (2016) Stimulation of Slack K+ channels alters mass at the plasma membrane by triggering disassociation of a phosphatase-regulatory complex. Cell Reports 16, 2281-2288, (PMCID: PMC5123741).
174. Cantley, L., Colangelo, C., Stone, K., Chung, L., Belcher, J., Abbott, T., Cantley, J., Williams, K., and Parikh, C. (2016) Development of a Targeted Urine Proteome Assay for Kidney Diseases. Proteomics Clinical Applications 10, 58-74, (PMCID: PMC5003777).
173. Engmann, O., Giralt, A., Gervasi, N., Marion-Poll, L., Gasmi, L., Filhol, O., Picciotto, M.R., Gilligan, D., Greengard, P., Nairn, A.C., Hervé, D., Girault, J.A. (2015) DARPP-32 interaction with adducin may mediate rapid environment effects on striatal neurons. Nat. Commun. 6, (PMCID: PMC4675091).
172. Colangelo, C., Shifman, M., Cheung, K., Stone, K.L., Carriero, N., Gulcicek, E., Lam, T.T., Wu, T., Bjornson, R.D., Bruce, C., Nairn, A.C., Rinehart, J., Miller, P.L., and Williams, K. (2015) YPED: An integrated bioinformatics suite and database for mass spectrometry based proteomics research. Genomics, Proteomics, and Bioinformatics 13(1), 25-35, (PMCID: PMC4411476).
171. Colangelo, C., Ivosev, G., Chung, L., Abbott, T., Shifman, M., Sakaue, F., Cox, D., Kitchen, R., Burton, L., Tate, S., Gulcicek, E., Bonner, R., Rinehart, J., Nairn, A., and Williams, K. (2015) Development of a highly automated and multiplexed targeted proteome pipeline and assay for 112 rat brain synaptic proteins. Proteomics 15, 1202-1214, (PMCID: PMC4698340).
170. Shibata, S., Arroyo, J.P., Castañeda-Bueno, M., Puthumana, J., Zhang, J., Uchida, S., Stone, K.L., Lam, T.T., Lifton, R.P. (2014) Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation. Proc. Natl. Acad. Sci. U S A. 111(43),15556-61, (PMCID: PMC4217463).
169. Ma, X.M., Miller, M.B., Vishwanatha, K.S., Gross, M., Wang, Y., Abbott, T., Lam, T.T., Mains, R.E., Eipper, B.A. (2014) Non-enzymatic domains of Kalirin7 contribute to spine morphogenesis through interactions with phosphoinositides and Abl. Mol. Biol. Cell 25(9),1458-71 (PMCID: PMC4004595).
168. Tellez, L. A., Medina, S., Han, W., Ferreira, J. G., Licona-Limon, P., Ren, X., Lam, T. T., Schwartz, G. J., and de Araujo, I. E. (2013) A gut lipid messenger links excess dietary fat to dopamine deficiency. Science 341, 800-802. (PMID: 23950538)
167. Shibata, S., Zhang, J., Puthumana, J., Stone, K. L., and Lifton, R. P. (2013) Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4. Proc. Natl. Acad. Sci. U. S. A. 110, 7838-7843, (PMCID: PMC3651502).
166. Robison, A. J., Vialou, V., Mazei-Robison, M., Feng, J., Kourrich, S., Collins, M., Wee, S., Koob, G., Turecki, G., Neve, R., Thomas, M., and Nestler, E. J. (2013) Behavioral and structural responses to chronic cocaine require a feedforward loop involving DeltaFosB and calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell. J Neurosci. 33, 4295-4307, (PMCID: PMC3658178).
165. McClure-Begley, T. D., Stone, K. L., Marks, M. J., Grady, S. R., Colangelo, C. M., Lindstrom, J. M., and Picciotto, M. R. (2013) Exploring the nicotinic acetylcholine receptor-associated proteome with iTRAQ and transgenic mice. Genomics Proteomics Bioinformatics 11, 207-218, (PMCID: PMC3806329).
164. Ko, J. H., Wang, Y. S., Nakamura, A., Guo, L. T., Soll, D., and Umehara, T. (2013) Pyrrolysyl-tRNA synthetase variants reveal ancestral aminoacylation function. FEBS Lett. 587, 3243-3248, (PMCID: PMC3778162).
163. Ivanov, A. R., Colangelo, C. M., Dufresne, C. P., Friedman, D. B., Lilley, K. S., Mechtler, K., Phinney, B. S., Rose, K. L., Rudnick, P. A., Searle, B. C., Shaffer, S. A., and Weintraub, S. T. (2013) Interlaboratory studies and initiatives developing standards for proteomics. Proteomics 13, 904-909, (PMCID: PMC3863631).
162. Colangelo, C. M., Chung, L., Bruce, C., and Cheung, K. H. (2013) Review of software tools for design and analysis of large scale MRM proteomic datasets. Methods 61, 287-298, (PMCID: PMC 3775261).
161. Bruce, C., Stone, K., Gulcicek, E., and Williams, K. (2013) Proteomics and the analysis of proteomic data: 2013 overview of current protein-profiling technologies. Curr. Protoc. Bioinformatics 41, 13.21.1-13.21.17 (PMCID: PMC 3688054).
160. Bansal, N., Zhang, M., Bhaskar, A., Itotia, P., Lee, E., Shlyakhtenko, L. S., Lam, T. T., Fritz, A., Berezney, R., Lyubchenko, Y. L., Stafford, W. F., and Thapar, R. (2013) Assembly of the SLIP1-SLBP complex on histone mRNA requires heterodimerization and sequential binding of SLBP followed by SLIP1. Biochemistry 52, 520-536, (PMCID: PMC 3580866).
159. Antinone, S. E., Ghadge, G. D., Lam, T. T., Wang, L., Roos, R. P., and Green, W. N. (2013) Palmitoylation of superoxide dismutase 1 (SOD1) is increased for familial amyotrophic lateral sclerosis-linked SOD1 mutants. J. Biol. Chem. 288, 21606-21617, (PMCID: PMC 3724620).
158. Zhang, Y. Q., Henderson, M. X., Colangelo, C. M., Ginsberg, S. D., Bruce, C., Wu, T., and Chandra, S. S. (2012) Identification of CSPalpha clients reveals a role in dynamin 1 regulation. Neuron 74, 136-150, (PMCID: PMC 3328141).
157. Zhang, M., Lam, T. T., Tonelli, M., Marzluff, W. F., and Thapar, R. (2012) Interaction of the histone mRNA hairpin with stem-loop binding protein (SLBP) and regulation of the SLBP-RNA complex by phosphorylation and proline isomerization. Biochemistry 51, 3215-3231, (PMCID: PMC 3328597).
156. Sherwin, R., Slayman, C., Rockwell, S., Williams, K., Carson, R., Mane, S., Seow, H., Max, J., and Johnson, T. (2012) Yale Center for Clinical Investigation: Leveraging Industry Partnerships and Research Cores. Clinical and Translational Science 5, 435-436,
155. Shen, H., Song, Y., Colangelo, C. M., Wu, T., Bruce, C., Scabia, G., Galan, A., Maffei, M., and Goldstein, D. R. (2012) Haptoglobin activates innate immunity to enhance acute transplant rejection in mice. J. Clin. Invest. 122, 383-387, (PMCID: PMC 3248290).
154. Sathyanesan, M., Girgenti, M. J., Banasr, M., Stone, K., Bruce, C., Guilchicek, E., Wilczak-Havill, K., Nairn, A., Williams, K., Sass, S., Duman, J. G., and Newton, S. S. (2012) A molecular characterization of the choroid plexus and stress-induced gene regulation. Transl. Psychiatry 2, e139, (PMCID: PMC 3410626).
153. Marin, E. P., Derakhshan, B., Lam, T. T., Davalos, A., and Sessa, W. C. (2012) Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases. Circ. Res. 110, 1336-1344, (PMCID: PMC 3428238).
152. Krishnan, N., Lam, T. T., Fritz, A., Rempinski, D., O'Loughlin, K., Minderman, H., Berezney, R., Marzluff, W. F., and Thapar, R. (2012) The prolyl isomerase Pin1 targets stem-loop binding protein (SLBP) to dissociate the SLBP-histone mRNA complex linking histone mRNA decay with SLBP ubiquitination. Mol. Cell. Biol. 32, 4306-4322, (PMCID: PMC 3486140).
151. Ye, Z. J., Gulcicek, E., Stone, K., Lam, T., Schulz, V., and Weissman, S. M. (2011) Complex interactions in EML cell stimulation by stem cell factor and IL-3. Proc. Natl. Acad. Sci. U. S. A. 108, 4882-4887, (PMCID: PMC 3064389).
150. Shabman, RS.; D W. Leung, J Johnson, N Glennon, EE Gulcicek, KL Stone; L Leung, L Hensley, G K. Amarasinghe, Christopher F. Basler (2011) DRBP76 associates with ebolavirus VP35 and suppresses viral polymerase function. J. Infect. Dis. 204, S911-S918; (PMID: 2198776).
149. Shabman, R. S., Gulcicek, E. E., Stone, K. L., and Basler, C. F. (2011) The Ebola virus VP24 protein prevents hnRNP C1/C2 binding to karyopherin alpha1 and partially alters its nuclear import. J. Infect. Dis. 204 Suppl. 3, S904-910, (PMCID: PMC 3189985).
148. Rinehart, J., Vazquez, N., Kahle, K. T., Hodson, C. A., Ring, A. M., Gulcicek, E. E., Louvi, A., Bobadilla, N. A., Gamba, G., and Lifton, R. P. (2011) WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters. J. Biol. Chem. 286, 30171-30180, (PMCID: PMC 3191056).
147. Pirruccello, M., Swan, L. E., Folta-Stogniew, E., and De Camilli, P. (2011) Recognition of the F&H motif by the Lowe syndrome protein OCRL. Nat. Struct. Mol. Biol. 18, 789-795, (PMCID: PMC 3130824).
146. Noga, E. J., Stone, K. L., Wood, A., Gordon, W. L., and Robinette, D. (2011) Primary structure and cellular localization of callinectin, an antimicrobial peptide from the blue crab. Dev Comp. Immunol. 35, 409-415, (PMCID: PMC 3046215).
145. Kiraly, D. D., Stone, K. L., Colangelo, C. M., Abbott, T., Wang, Y., Mains, R. E., and Eipper, B. A. (2011) Identification of kalirin-7 as a potential post-synaptic density signaling hub. J Proteome Res. 10, 2828-2841, (PMCID: PMC 3107868).
144. Bordner, K. A., George, E. D., Carlyle, B. C., Duque, A., Kitchen, R. R., Lam, T. T., Colangelo, C. M., Stone, K. L., Abbott, T. B., Mane, S. M., Nairn, A. C., and Simen, A. A. (2011) Functional genomic and proteomic analysis reveals disruption of myelin-related genes and translation in a mouse model of early life neglect. Front. Psychiatry 2, 18, (PMCID: PMC 3098717).
143. Bianchetta, M. J., Lam, T. T., Jones, S. N., and Morabito, M. A. (2011) Cyclin-dependent kinase 5 regulates PSD-95 ubiquitination in neurons. J. Neurosci. 31, 12029-12035, (PMCID: PMC 3190401).
142. Seo, J. K., Stephenson, J., Crawford, M., Stone, K. L., and Noga, E. J. (2010) American oyster, Crassostrea virginica, expresses a potent antibacterial histone H2B protein. Mar Biotechnol. (NY) 12, 543-551.
141. Rajagopal, C., Stone, K. L., Mains, R. E., and Eipper, B. A. (2010) Secretion stimulates intramembrane proteolysis of a secretory granule membrane enzyme. J. Biol. Chem. 285, 34632-34642, (PMCID: PMC 2966079).
140. Du, J., Roberts, D., Lin, K., Belcourt, M., King, I., and Lam, T.K. (2010) Case Study: Identification of in vitro metabolite/decomposition products of the novel DNA alkylating agent laromustine, in Biotransformation and Metabolite Elucidation of Xenobiotics: Characterization and Identification (Nassar, A. ed) Chapter 6.
139. Nassar, A.F., Du, J., Roberts, D., Lin, K., Belcourt, M., King, I., and Lam, T.K. (2010) Case Study: The unanticipated loss of N2 from novel DNA alkylating agent laromustine by collision-induced dissociation: Novel Rearrangements, in Biotransformation and Metabolite Elucidation of Xenobiotics: Characterization and Identification (Nassar, A. ed.), Chapter 5.
138. Fogel, A. I., Li, Y., Giza, J., Wang, Q., Lam, T. T., Modis, Y., and Biederer, T. (2010) N-glycosylation at the SynCAM (synaptic cell adhesion molecule) immunoglobulin interface modulates synaptic adhesion. J. Biol. Chem. 285, 34864-34874, (PMCID: PMC 2966101).
137. Ercan-Sencicek, A. G., Stillman, A. A., Ghosh, A. K., Bilguvar, K., O'Roak, B. J., Mason, C. E., Abbott, T., Gupta, A., King, R. A., Pauls, D. L., Tischfield, J. A., Heiman, G. A., Singer, H. S., Gilbert, D. L., Hoekstra, P. J., Morgan, T. M., Loring, E., Yasuno, K., Fernandez, T., Sanders, S., Louvi, A., Cho, J. H., Mane, S., Colangelo, C. M., Biederer, T., Lifton, R. P., Gunel, M., and State, M. W. (2010) L-histidine decarboxylase and Tourette's syndrome. N. Engl. J. Med. 362, 1901-1908, (PMCID: PMC 2894694).
136. Davalos, A., Fernandez-Hernando, C., Sowa, G., Derakhshan, B., Lin, M. I., Lee, J. Y., Zhao, H., Luo, R., Colangelo, C., and Sessa, W. C. (2010) Quantitative proteomics of caveolin-1-regulated proteins: characterization of polymerase i and transcript release factor/CAVIN-1 IN endothelial cells. Mol. Cell. Proteomics 9, 2109-2124, (PMCID: PMC 2953909).
135. Alexander, J. K., Govind, A. P., Drisdel, R. C., Blanton, M. P., Vallejo, Y., Lam, T. T., and Green, W. N. (2010) Palmitoylation of nicotinic acetylcholine receptors. J. Mol. Neurosci. 40, 12-20, (PMCID: PMC 3523180).
2000 to 2009
1990 to 1999
96. Stone, K. Fernandez, J., Admon, A. Henzel, W. Lane, W. Rohde, M. and Steinke, L. (1999) ABRF-97 SEQ: Sequencing Results of a Low-Level Sample. Journal of Biomolecular Techniques, 10 (1), 26-32.
95. Mische, S., Hellman, U., Speicher, D., and Williams, K. (1999) Internal Protein Sequencing, in Encyclopedia of Bioprocess Technology (Flickinger, M. C., and Drew, S. W. ed), John Wiley & Sons, 2099-2103.
94. Gordon, J., Sengupta, T. K., Phillips, C. A., O'Malley, S. M., Williams, K. R., and Spicer, E. K. (1999) Identification of the RNA binding domain of T4 RegA protein by structure-based mutagenesis. J. Biol. Chem. 274, 32265-32273.
93. Stone, K. L., DeAngelis, R., LoPresti, M., Jones, J., Papov, V. V., and Williams, K. R. (1998) Use of liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) for routine identification of enzymatically digested proteins separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Electrophoresis 19, 1046-1052.
92. Kim, S., Park, G. H., Joo, W. A., Paik, W. K., Cook, R. J., and Williams, K. R. (1998) Identification of protein-arginine N-methyltransferase as 10-formyltetrahydrofolate dehydrogenase. J. Biol. Chem. 273, 27374-27382.
91. Williams, K. R., and Stone, K. L. (1997) Enzymatic cleavage and HPLC peptide mapping of proteins. Mol Biotechnol 8, 155-167.
90. Williams, K. R., LoPresti, M., and Stone, K. (1997) Internal protein sequencing of SDS-PAGE-separated proteins: Optimization of an in gel digest protocol, in Techniques in Protein Chemistry VIII (Marshak, D. ed), Academic Press, San Diego, 79-90.
89. Williams, K., Hellman, U., Kobayashi, R., Lane, W., Mische, S., and Speicher, D. (1997) Internal protein sequencing of SDS-PAGE separated proteins: A collaborative ABRF study. In Techniques in Protein Chemistry VIII, (Marshak, D. ed), Academic Press, San Diego, 99-109.
88. Kim, S., Merrill, B. M., Rajpurohit, R., Kumar, A., Stone, K. L., Papov, V. V., Schneiders, J. M., Szer, W., Wilson, S. H., Paik, W. K., and Williams, K. R. (1997) Identification of N(G)-methylarginine residues in human heterogeneous RNP protein A1: Phe/Gly-Gly-Gly-Arg-Gly-Gly-Gly/Phe is a preferred recognition motif. Biochemistry 36, 5185-5192.
87. Fernandez, J., Admon, A., DeJongh, K. Grant, G. Henzel, W. Lane, W.S., Stone, K.L., and Merrill, B. (1997) Evaluation of ABRF-96SEQ: A sequence Assignment Exercise. In: Techniques in Protein Chemistry VIII (Marshak, D.R. ed.) Academic Press, Orlando, 69-78.
86. Williams, K. R., Samandar, S. M., Stone, K. L., Saylor, M., and Rush, J. (1996) Matrix assisted-laser desorption ionization mass spectrometry as a complement to internal protein sequencing., in The Protein Protocols Handbook (Walker, J. M. ed), Humana Press, Totowa, 541-555.
85. Stone, K. L., and Williams, K. R. (1996) Reverse phase HPLC separation of enzymatic digests of proteins, in The Protein Protocols Handbook (Walker, J. M. ed), Humana Press, Totowa, 427-434.
84. Stone, K. L., and Williams, K. R. (1996) Enzymatic digestion of proteins in solution and in SDS polyacrylamide gels, in The Protein Protocols Handbook, (Walker, J. M. ed), Humana Press, Totowa, 415-425.
83. McAtee, C. P., Zhang, Y., Yarbough, P. O., Fuerst, T. R., Stone, K. L., Samander, S., and Williams, K. R. (1996) Purification and characterization of a recombinant hepatitis E protein vaccine candidate by liquid chromatography-mass spectrometry. J. Chromatogr. B Biomed Appl 685, 91-104.
82. DeJongh, K., Fernandez, J., Gambee, J.E., Grant, G.A., Merrill,B., Stone, K.L. and Rush, J. (1996) Design and Analysis of ABRF-95SEQ, a Recombinant Protein With Sequence Heterogeneity. In: Techniques in Protein Chemistry VII (Marshak, D.R. ed.) Academic Press, Orlando, 347-358.
81. Williams, K. R., and Stone, K. L. (1995) In gel digestion of SDS PAGE-separated proteins: Observations from internal sequencing of 25 proteins, in Techniques in Protein Chemistry VI (Crabb, J. W. ed), Academic Press, Orlando, 143-152.
80. Williams, K. R., and Stone, K. L. (1995) Identifying sites of posttranslational modifications in proteins via HPLC peptide mapping. Methods Mol. Biol. 40, 157-175.
79. Williams, K. R., and Carr, S. A. (1995) Protein analysis: Integrated sample preparation, chemistry, and mass spectrometry, in Encyclopedia of Molecular Biology and Biotechnology, (Meyers, R. A. ed), VCH Publishers, New York, 731-737.
78. Stone, K. L., and Williams, K. R. (1995) Digestion of proteins in gels for sequence analysis, in Current Protocols in Protein Science, (Colligan, J., Smith, J., Ploegh, H., Speicher, D., and Wingfield, P. ed), John Wiley & Sons, New York, 11.3.1-11.3.13.
77. Rawal, N., Rajpurohit, R., Lischwe, M. A., Williams, K. R., Paik, W. K., and Kim, S. (1995) Structural specificity of substrate for S-adenosylmethionine:protein arginine N-methyltransferases. Biochim. Biophys. Acta 1248, 11-18.
76.
Williams, K.R. and Stone, K.L. (1994) Identifying sites of posttranslational modifications in proteins via HPLC peptide mapping in
Methods in Molecular Biology: Protein Stability and Folding Protocols. (Shirley, B.A., ed.) Humana Press, Totowa, N.J. Vol. 40, pp. 157-175.
75. Williams, K. R., Shamoo, Y., Spicer, E. K., Coleman, J. E., and Konigsberg, W. H. (1994) Correlating structure to function in proteins: T4 gp32 as a prototype, in Bacteriophage T4, (Karam, J. ed), American Society of Microbiology, Washington, D.C., 301-304.
74. Reich, E. P., von Grafenstein, H., Barlow, A., Swenson, K. E., Williams, K., and Janeway, C. A., Jr. (1994) Self peptides isolated from MHC glycoproteins of non-obese diabetic mice. J Immunol 152, 2279-2288.
73. Stone, K. L., and Williams, K. R. (1993) Enzymatic digestion of proteins and HPLC peptide isolation, in A Practical Guide to Protein and Peptide Purification for Microsequencing, (Matsudaira, P. ed), 2nd ed., Academic Press, New York, 43-69.
72. Elliott, J. I., Stone, K. L., and Williams, K. R. (1993) Synthesis and use of an internal amino acid sequencing standard peptide. Anal Biochem 211, 94-101.
71. Chaudhuri, A., Polyakova, J., Zbrzezna, V., Williams, K., Gulati, S., and Pogo, A. O. (1993) Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite. Proc. Natl. Acad. Sci. U. S. A. 90, 10793-10797, (PMCID: PMC 47864).
70. Webster, K. R., Keill, S., Konigsberg, W., Williams, K. R., and Spicer, E. K. (1992) Identification of amino acid residues at the interface of a bacteriophage T4 regA protein-nucleic acid complex. J. Biol. Chem. 267, 26097-26103.
69. Stone, K. L., McNulty, D. E., LoPresti, M. L., Crawford, J. M., DeAngelis, R., and Williams, K. R. (1992) Elution and internal amino acid sequencing of PVDF-blotted proteins, in Techniques in Protein Chemistry III, (Angeletti, R. ed), Academic Press, New York, 23-34.
68. Shuai, K., Das Gupta, C. K., Hawley, R. S., Chase, J. W., Stone, K. L., and Williams, K. R. (1992) Purification and characterization of an endo-exonuclease from adult flies of Drosophila melanogaster. Nucleic Acids Res. 20, 1379-1385, (PMCID: PMC 312186).
67. Yüksel, K. Ü., Grant, G. A., Mende-Mueller, L. M., Niece, R. L., Williams, K. R., and Speicher, D. W. (1991) Protein sequencing from polyvinylidenedifluoride membranes: Design and characterization of a test sample (ABRF-90SEQ) and evaluation of results, in Techniques in Protein Chemistry II, (Villafranca, J. J. ed), Academic Press, New York, 151-162.
66. Williams, K. R., and Konigsberg, W. H. (1991) Identification of amino acid residues at interface of protein-nucleic acid complexes by photochemical cross-linking. Methods Enzymol. 208, 516-539.
65. Stone, K. L., LoPresti, M. B., Crawford, J. M., DeAngelis, R., and Williams, K. R. (1991) Reverse-phase HPLC separation of sub-nanomole amounts of peptides obtained from enzymatic digests., in High Performance Liquid Chromatography of peptides and proteins: Separation, Analysis and Conformation, (Mant, C. T., and Hodges, R. S. ed), CRC Press, Boca Raton, Florida, 669-677.
64. Ruvolo, P. P., Keating, K. M., Williams, K. R., and Chase, J. W. (1991) Single-stranded DNA binding proteins (SSBs) from prokaryotic transmissible plasmids. Proteins 9, 120-134.
63. Niece, R. L., Ericsson, L. H., Fowler, A. V., Smith, A. J., Speicher, D. W., Crabb, J. W., and Williams, K. R. (1991) Amino acid analysis and sequencing - what is state-of-the-art?, (Jornvall, H., Hoog, and Gustavsson ed), Birkhauser Verlag, Basel, 133-141.
62. Williams, K. R., and Chase, J. W. (1990) Eukaryotic single-stranded nucleic acid binding proteins, in The Biology of Nonspecific DNA-Protein Interactions, (Revzin, A. ed), CRC Press, Boca Raton, Florida, 197-227.
61. Stone, K. L., LoPresti, M. B., and Williams, K. R. (1990) Enzymatic digestion of proteins and HPLC peptide isolation in the sub-nanomole range, in Laboratory Methodology in Biochemistry: Amino Acid Analysis and Protein Sequencing, (Fini, C., Floridi, A., Finelli, V. N., and Wittman-Liebold, B. ed), CRC Press, Boca Raton, Florida, 181-205.
60. Stone, K. L., Elliott, J. I., Peterson, G., McMurray, W., and Williams, K. R. (1990) Reversed-phase high-performance liquid chromatography for fractionation of enzymatic digests and chemical cleavage products of proteins. Methods Enzymol. 193, 389-412.
59. Speicher, D. W., Grant, G. A., Niece, R. L., Blacher, R. W., Fowler, A. V., and Williams, K. R. (1990) Design, characterization, and results of ABRF-89SEQ: A test sample for evaluating protein sequencer performance in protein microchemistry core facilities, in Current Research in Protein Chemistry: Techniques, Structure, and Function, (Villafranca, J. J. ed), Academic Press, New York, 159-166.
58. Shamoo, Y., Keating, K., Williams, K. R., and Konigsberg, W. H. (1990) Structure/function relationships in the bacteriophage T4 single-stranded DNA-binding protein, in Molecular Biology of Chromosome Function, (Adolph, K. W. ed), Springer-Verlag, New York, 302-322.
57. Merrill, B. M., and Williams, K. R. (1990) Structure/function relationships in hnRNP proteins, in The Eukaryotic Nucleus: Molecular Biochemistry and Macromolecular Assemblies, (Strauss, P. R., and Wilson, S. H. ed), Telford Press, New Jersey, 579-604.
56. Kumar, A., Widen, S. G., Williams, K. R., Kedar, P., Karpel, R. L., and Wilson, S. H. (1990) Studies of the domain structure of mammalian DNA polymerase beta. Identification of a discrete template binding domain. J. Biol. Chem. 265, 2124-2131.
55. Kumar, A., Casas-Finet, J. R., Luneau, C. J., Karpel, R. L., Merrill, B. M., Williams, K. R., and Wilson, S. H. (1990) Mammalian heterogeneous nuclear ribonucleoprotein A1. Nucleic acid binding properties of the COOH-terminal domain. J. Biol. Chem. 265, 17094-17100.
54. Horiuchi, A., Williams, K. R., Kurihara, T., Nairn, A. C., and Greengard, P. (1990) Purification and cDNA cloning of ARPP-16, a cAMP-regulated phosphoprotein enriched in basal ganglia, and of a related phosphoprotein, ARPP-19. J. Biol. Chem. 265, 9476-9484.
53. Collins, E. J., Robertus, J. D., LoPresti, M., Stone, K. L., Williams, K. R., Wu, P., Hwang, K., and Piatak, M. (1990) Primary amino acid sequence of alpha-trichosanthin and molecular models for abrin A-chain and alpha-trichosanthin. J. Biol. Chem. 265, 8665-8669.
1980 to 1989
52. Williams, K. R., Hemmings, H. C., Jr., LoPresti, M. B., and Greengard, P. (1989) ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Amino acid sequence of ARPP-21B from bovine caudate nucleus. J Neurosci 9, 3631-3637.
51. Stone, K. L., LoPresti, M. L., Williams, N. D., Crawford, J. M., DeAngeles, R., and Williams, K. R. (1989) Enzymatic digestion of proteins and HPLC peptide isolation in the sub-nanomole range, in Techniques in Protein Chemistry, (Hugli, T. E. ed), Academic Press, New York, 377-391.
50. Stone, K. L., LoPresti, M. B., Crawford, J. M., DeAngelis, R., and Williams, K. R. (1989) Enzymatic digestion of proteins and HPLC peptide isolation, in A Practical Guide to Protein and Peptide Purification for Microsequencing, (Matsudaira, P. ed), Academic Press, New York, 33-47.
49. Rush, J., Lin, T. C., Quinones, M., Spicer, E. K., Douglas, I., Williams, K. R., and Konigsberg, W. H. (1989) The 44P subunit of the T4 DNA polymerase accessory protein complex catalyzes ATP hydrolysis. J. Biol. Chem. 264, 10943-10953.
48. Niece, R. L., Williams, K. R., Wadsworth, C. L., Elliott, J., Stone, K. L., McMurray, W. J., Fowler, A., Atherton, D., Kutny, R., and Smith, A. (1989) A synthetic peptide for evaluating protein sequencer and amino acid analyzer performance in core facilities: Design and results, in Techniques in Protein Chemistry, (Hugli, T. E. ed), Academic Press, New York, 89-101.
47. Merrill, B. M., Barnett, S. F., LeStourgeon, W. M., and Williams, K. R. (1989) Primary structure differences between proteins C1 and C2 of HeLa 40S nuclear ribonucleoprotein particles. Nucleic Acids Res. 17, 8441-8449, (PMCID: PMC 335017).
46. Hemmings, H. C., Jr., Girault, J. A., Williams, K. R., LoPresti, M. B., and Greengard, P. (1989) ARPP-21, a cyclic AMP-regulated phosphoprotein (Mr = 21,000) enriched in dopamine-innervated brain regions. Amino acid sequence of the site phosphorylated by cyclic AMP in intact cells and kinetic studies of its phosphorylation in vitro. J. Biol. Chem. 264, 7726-7733.
45. Girault, J. A., Hemmings, H. C., Jr., Williams, K. R., Nairn, A. C., and Greengard, P. (1989) Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase II. J. Biol. Chem. 264, 21748-21759.
44. Elliott, J., Stone, K., Roberts, W., LoPresti, M., Crawford, M., Kapouch, J., Jacobsen, E., Williams, K. R., McMurray, W., Meng, C., Mann, M., and Fenn, J. (1989) Structure of symposium test peptide-3, in Techniques in Protein Chemistry, (Hugli, T. E. ed), Academic Press, New York, 569-579.
43. Stone, K. L., and Williams, K. (1988) Small bore HPLC purification of peptides in the subnanomole range, in Macromolecular Sequencing and Synthesis, (Schlesinger, D. H. ed), Alan R. Liss, New York, 7-24.
42. Shamoo, Y., Williams, K. R., and Konigsberg, W. H. (1988) Photochemical crosslinking of bacteriophage T4 single-stranded DNA-binding protein (gp32) to oligo-p(dT)8: identification of phenylalanine-183 as the site of crosslinking. Proteins 4, 1-6.
41. Merrill, B. M., Stone, K. L., Cobianchi, F., Wilson, S. H., and Williams, K. R. (1988) Phenylalanines that are conserved among several RNA-binding proteins form part of a nucleic acid-binding pocket in the A1 heterogeneous nuclear ribonucleoprotein. J. Biol. Chem. 263, 3307-3313.
40. Cobianchi, F., Karpel, R. L., Williams, K. R., Notario, V., and Wilson, S. H. (1988) Mammalian heterogeneous nuclear ribonucleoprotein complex protein A1. Large-scale overproduction in Escherichia coli and cooperative binding to single-stranded nucleic acids. J. Biol. Chem. 263, 1063-1071.
39. Williams, K. R., Stone, K. L., Fritz, M. K., Merrill, B. M., Konigsberg, W. H., Pandolfo, M., Valentini, O., Reddigari, S., Patel, G. L., and Chase, J. W. (1987) Use of HPLC comparative peptide mapping in structure/function studies., in Proteins: Structure and Function., (L'Italien, J. J. ed), 45-52.
38. Spicer, E. K., Horton, R., Bloem, L., Bach, R., Williams, K. R., Guha, A., Kraus, J., Lin, T. C., Nemerson, Y., and Konigsberg, W. H. (1987) Isolation of cDNA clones coding for human tissue factor: primary structure of the protein and cDNA. Proc. Natl. Acad. Sci. U. S. A. 84, 5148-5152, (PMCID: PMC 298811).
37. Pandey, V. N., Williams, K. R., Stone, K. L., and Modak, M. J. (1987) Photoaffinity labeling of the thymidine triphosphate binding domain in Escherichia coli DNA polymerase I: identification of histidine-881 as the site of cross-linking. Biochemistry 26, 7744-7748.
36. Merrill, B. M., Lopresti, M. B., Stone, K. L., and Williams, K. R. (1987) Amino acid sequence of UP1, an hnRNP-derived single-stranded nucleic acid binding protein from calf thymus. Int. J. Pept. Protein Res. 29, 21-39.
35. Coleman, J. E., Williams, K. R., King, G. C., Prigodich, R. V., Shamoo, Y., and Konigsberg, W. H. (1987) Mapping the functional domains in single-strand DNA-binding proteins gene 5 and gene 32. , in Protein Engineering, (Oxender, D., and Fox, C. F. ed), Alan R. Liss, N.Y., 323-336.
34. Basu, A., Williams, K. R., and Modak, M. J. (1987) Ferrate oxidation of Escherichia coli DNA polymerase-I. Identification of a methionine residue that is essential for DNA binding. J. Biol. Chem. 262, 9601-9607.
33. Williams, K. R., Williams, N. D., Konigsberg, W., and Yu, R. K. (1986) Acidic lipids enhance cathepsin D cleavage of the myelin basic protein. J. Neurosci. Res. 15, 137-145.
32. Williams, K. R., Hemmings, H. C., Jr., LoPresti, M. B., Konigsberg, W. H., and Greengard, P. (1986) DARPP-32, a dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Primary structure and homology with protein phosphatase inhibitor-1. J. Biol. Chem. 261, 1890-1903.
31. Stone, K.L., Williams, K.R., Rabin, B.A., Murphy, J.B., Chase, J.W. and Pfeifer, R. (1986) HPLC purification and identification of peptides using microbore columns. Waters Journal, 20-27.
30. Stone, K. L., and Williams, K. R. (1986) High-performance liquid chromatographic peptide mapping and amino acid analysis in the sub-nanomole range. J. Chromatogr. 359, 203-212.
29. Shamoo, Y., Adari, H., Konigsberg, W. H., Williams, K. R., and Chase, J. W. (1986) Cloning of T4 gene 32 and expression of the wild-type protein under lambda promoter PL regulation in Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 83, 8844-8848, (PMCID: PMC 387029).
28. Riva, S., Morandi, C., Tsoulfas, P., Pandolfo, M., Biamonti, G., Merrill, B., Williams, K. R., Multhaup, G., Beyreuther, K., Werr, H., and et al. (1986) Mammalian single-stranded DNA binding protein UP I is derived from the hnRNP core protein A1. EMBO J. 5, 2267-2273, (PMCID: PMC 1167110).
27. Merrill, B. M., LoPresti, M. B., Stone, K. L., and Williams, K. R. (1986) High pressure liquid chromatography purification of UP1 and UP2, two related single-stranded nucleic acid-binding proteins from calf thymus. J. Biol. Chem. 261, 878-883.
26. Kumar, A., Williams, K. R., and Szer, W. (1986) Purification and domain structure of core hnRNP proteins A1 and A2 and their relationship to single-stranded DNA-binding proteins. J. Biol. Chem. 261, 11266-11273.
25. Kraus, J. P., Firgaira, F., Novotny, J., Kalousek, F., Williams, K. R., Williamson, C., Ohura, T., and Rosenberg, L. E. (1986) Coding sequence of the precursor of the beta subunit of rat propionyl-CoA carboxylase. Proc. Natl. Acad. Sci. U. S. A. 83, 8049-8053, (PMCID: PMC 386864).
24. Coleman, J. E., Williams, K. R., King, G. C., Prigodich, R. V., Shamoo, Y., and Konigsberg, W. H. (1986) Protein chemistry-nuclear magnetic resonance approach to mapping functional domains in single-stranded DNA binding proteins. J. Cell. Biochem 32, 305-326.
23. Chase, J. W., Rabin, B. A., Murphy, J. B., Stone, K. L., and Williams, K. R. (1986) Escherichia coli exonuclease VII. Cloning and sequencing of the gene encoding the large subunit (xseA). J. Biol. Chem. 261, 14929-14935.
22. Williams, K. R., Stone, K. L., LoPresti, M. B., Merrill, B. M., and Planck, S. R. (1985) Amino acid sequence of the UP1 calf thymus helix-destabilizing protein and its homology to an analogous protein from mouse myeloma. Proc. Natl. Acad. Sci. U. S. A. 82, 5666-5670, (PMCID: PMC 390612).
21. Williams, K. R., Reddigari, S., and Patel, G. L. (1985) Identification of a nucleic acid helix-destabilizing protein from rat liver as lactate dehydrogenase-5. Proc. Natl. Acad. Sci. U. S. A. 82, 5260-5264, (PMCID: PMC 390547).
20. Kraus, J. P., Hodges, P. E., Williamson, C. L., Horwich, A. L., Kalousek, F., Williams, K. R., and Rosenberg, L. E. (1985) A cDNA clone for the precursor of rat mitochondrial ornithine transcarbamylase: comparison of rat and human leader sequences and conservation of catalytic sites. Nucleic Acids Res. 13, 943-952, (PMCID: PMC 341044).
19. Chase, J. W., Flory, J., Ruddle, N. H., Murphy, J. B., and Williams, K. R. (1985) A monoclonal antibody that recognizes the functional domain of Escherichia coli single-stranded DNA binding protein that includes the ssb-113 mutation. J. Biol. Chem. 260, 7214-7218.
18. Adari, H. Y., Rose, K., Williams, K. R., Konigsberg, W. H., Lin, T. C., and Spicer, E. K. (1985) Cloning, nucleotide sequence, and overexpression of the bacteriophage T4 regA gene. Proc. Natl. Acad. Sci. U. S. A. 82, 1901-1905, (PMCID: PMC 397441).
17. Williams, K. R., Murphy, J. B., and Chase, J. W. (1984) Characterization of the structural and functional defect in the Escherichia coli single-stranded DNA binding protein encoded by the ssb-1 mutant gene. Expression of the ssb-1 gene under lambda pL regulation. J. Biol. Chem. 259, 11804-11811.
16. Spicer, E. K., Nossal, N. G., and Williams, K. R. (1984) Bacteriophage T4 gene 44 DNA polymerase accessory protein. Sequences of gene 44 and its protein product. J. Biol. Chem. 259, 15425-15432.
15. Patel, G., Reddigari, S., Williams, K. R., Baptist, E., Thompson, P., and Sisodia, S. (1984) A rat liver helix-destabilizing protein: properties and homology to LDH-5. , in Growth, Cancer, and the Cell Cycle, (Skehan, P., and Friedman, S. J. ed), Humana Press, Clifton, N.J., 41-58.
14. Paradiso, P. R., Williams, K. R., and Costantino, R. L. (1984) Mapping of the amino terminus of the H-1 parvovirus major capsid protein. J. Virol. 52, 77-81, (PMCID: PMC 254491).
13. Merrill, B. M., Williams, K. R., Chase, J. W., and Konigsberg, W. H. (1984) Photochemical cross-linking of the Escherichia coli single-stranded DNA-binding protein to oligodeoxynucleotides. Identification of phenylalanine 60 as the site of cross-linking. J. Biol. Chem. 259, 10850-10856.
12. Horwich, A. L., Fenton, W. A., Williams, K. R., Kalousek, F., Kraus, J. P., Doolittle, R. F., Konigsberg, W., and Rosenberg, L. E. (1984) Structure and expression of a complementary DNA for the nuclear coded precursor of human mitochondrial ornithine transcarbamylase. Science 224, 1068-1074.
11. Hemmings, H. C., Jr., Williams, K. R., Konigsberg, W. H., and Greengard, P. (1984) DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated neuronal phosphoprotein. I. Amino acid sequence around the phosphorylated threonine. J. Biol. Chem. 259, 14486-14490.
10. Chase, J. W., L'Italien, J. J., Murphy, J. B., Spicer, E. K., and Williams, K. R. (1984) Characterization of the Escherichia coli SSB-113 mutant single-stranded DNA-binding protein. Cloning of the gene, DNA and protein sequence analysis, high pressure liquid chromatography peptide mapping, and DNA-binding studies. J. Biol. Chem. 259, 805-814.
9. Williams, K. R., Spicer, E. K., LoPresti, M. B., Guggenheimer, R. A., and Chase, J. W. (1983) Limited proteolysis studies on the Escherichia coli single-stranded DNA binding protein. Evidence for a functionally homologous domain in both the Escherichia coli and T4 DNA binding proteins. J. Biol. Chem. 258, 3346-3355.
8. Williams, K., and Konigsberg, W. (1983) Structure-function relationships in the T4 single-stranded DNA binding protein, in Bacteriophage T4 Monograph, American Society for Microbiology 82-89.
7. Horwich, A. L., Kraus, J. P., Williams, K., Kalousek, F., Konigsberg, W., and Rosenberg, L. E. (1983) Molecular cloning of the cDNA coding for rat ornithine transcarbamoylase. Proc. Natl. Acad. Sci. U. S. A. 80, 4258-4262, (PMCID: PMC 384016).
6. Chase, J. W., Merrill, B. M., and Williams, K. R. (1983) F sex factor encodes a single-stranded DNA binding protein (SSB) with extensive sequence homology to Escherichia coli SSB. Proc. Natl. Acad. Sci. U. S. A. 80, 5480-5484, (PMCID: PMC 384281).
5. Williams, K., L'Italien, J., Guggenheimer, R., Sillerud, L., Spicer, E. K., Chase, J. W., and Konigsberg, W. H. (1982) Comparative peptide mapping by HPLC: identification of single amino acid substitutions in temperature sensitive mutants, in Methods in Protein Sequence Analysis, Humana Press, Clifton, N.J., 499-507.
4. Spicer, E. K., Noble, J. A., Nossal, N. G., Konigsberg, W. H., and Williams, K. R. (1982) Bacteriophage T4 gene 45. Sequences of the structural gene and its protein product. J. Biol. Chem. 257, 8972-8979.
3. Williams, K. R., LoPresti, M. B., and Setoguchi, M. (1981) Primary structure of the bacteriophage T4 DNA helix-destabilizing protein. J. Biol. Chem. 256, 1754-1762.
2. Sancar, A., Williams, K. R., Chase, J. W., and Rupp, W. D. (1981) Sequences of the ssb gene and protein. Proc. Natl. Acad. Sci. U. S. A. 78, 4274-4278, (PMCID: PMC 319772).
1. Williams, K. R., LoPresti, M. B., Setoguchi, M., and Konigsberg, W. H. (1980) Amino acid sequence of the T4 DNA helix-destabilizing protein. Proc. Natl. Acad. Sci. U. S. A. 77, 4614-4617, (PMCID: PMC 349895).