Core/facility:
Yale CryoEM Resource
Publications
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| Title | Journal |
|---|---|
| Cryo-structural insights into enzymatic peptide self-assembly driving extrinsic lytic cell death | J Am Chem Soc |
| Roles of microtubules and LIS1 in dynein transport machinery assembly | Nature |
| Clustering and a conformational switch drive activation of the mammalian receptor tyrosine kinase ROS1 | Nat Commun |
| Synaptic transmission: Munc13 assembles onto PI(4,5)P2-rich domains into trimers that cooperate to capture vesicles | PNAS |
| Structural basis of TACO1-mediated efficient mitochondrial translation | Nat Commun |
| Assembly and glycosylation of Helicobacter pylori sheathed flagella | PNAS Nexus |
| Oligomeric assembly of the gatekeeper InvE orchestrates hierarchical type III protein secretion in Salmonella typhimurium | PNAS |
| Ultrastructure analysis by cryo-electron tomography revealed mesosomes in the Gram-negative Delftia acidovorans | Microb Ecol |
| A nucleotide code governs Lis1’s ability to relieve dynein autoinhibition | Nat Chem Biol |
| Structural basis for bacteriophage P22 assembly and infection initiation | J Mol Biol |
| Structural insights into the assembly and evolution of a complex bacterial flagellar motor | Nat Microbiol |
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| Title | Journal |
|---|---|
| The role of kinase domain dimerization in EGFR activation | Structure |
| The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC | Nat Commun |
| Visualizing the translation landscape in human cells at high resolution | Nat Commun |
| Structural basis of bacteriophage Ur-lambda infection initiation | Sci Adv |
| Structure of the D1-Val185Asn mutated photosystem II complex with slow O–O bond formation reveals changes in the Cl1 water channel | PNAS |
| Distinct Target Site of Lenacapavir in Immature HIV-1 and Concurrent Binding with the Maturation Inhibitor Bevirimat | J Am Chem Soc |
| Structures of the sheathed flagellum reveal mechanisms of assembly and rotation in Vibrio cholerae | Nat Microbiol |
| Dissecting the Unique Self-Assembly Landscape of the HIV-2 Capsid Protein | Viruses |
| In situ structures of the Legionella Dot/Icm T4SS identify the DotA-IcmX complex as the gatekeeper for effector translocation | PNAS |
| Functional Dissection of the zDHHC Palmitoyltransferase 5-Golgin A7 Palmitoylation Complex | J Biol Chem |
| Mechanistic basis for a novel dual-function Gag-Pol dimerizer potentiating CARD8 inflammasome activation and clearance of HIV-infected cells | NPJ Drug Discov |
| Preclinical virology profiles of the HIV-1 capsid inhibitors VH4004280 and VH4011499 | Antimicrob Agents Chemother |
| A flexible peptide linking the periplasmic and cytoplasmic domains of MxiG controls type III secretion signaling and stable sorting platform assembly in Shigella | Front Cell Infect Microbiol |
| Two successive oligomeric Munc13 assemblies scaffold vesicle docking and SNARE assembly to support neurotransmitter release | Nat Commun |
| Nde1 promotes Lis1 binding to full-length autoinhibited human dynein 1 | Nat Struct Mol Biol |
| Saccharibacteria deploy two distinct type IV pili, driving episymbiosis, host competition, and twitching motility | ISME J |
| The Flagellin-Specific Chaperone FliS of Borrelia burgdorferi Controls the Cytoplasmic Pool of Flagellins at the Level of Translation Initiation, Secretion, and Proteolysis | Mol Microbiol |
| Outer membrane tube formation by Francisella novicida involves extensive envelope modifications and is linked with type VI secretion and alterations to the host phagosomal membrane | mBio |
| The mechanochemical cycle of reactive full-length human dynein 1 | Nat Struct Mol Biol |
| Cryo-EM structure of the brine shrimp mitochondrial ATP synthase suggests an inactivation mechanism for the ATP synthase leak channel | Cell Death Differ |
| Borrelia burgdorferi serine protease HtrA is a pleiotropic regulator of stress response, motility, flagellar hemostasis, and infectivity | Commun Biol |
| CryoEM structures of Kv1.2 potassium channels, conducting and non-conducting | eLife |
| Tetrameric PilZ protein stabilizes stator ring in complex flagellar motor and is required for motility in Campylobacter jejuni | PNAS |
| FlbB forms a distinctive ring essential for periplasmic flagellar assembly and motility in Borrelia burgdorferi | PLoS Pathog |
| Structure and evolution of photosystem I in the early-branching cyanobacterium Anthocerotibacter panamensis | PNAS |
| High-resolution structures of Myosin-IC reveal a unique actin-binding orientation, ADP release pathway, and power stroke trajectory | PNAS |
| Structure of a mutated photosystem II complex reveals changes to the hydrogen-bonding network that affect proton egress during O-O bond formation | J Biol Chem |
| Structural insights into HIV-2 CA lattice formation and FG-pocket binding revealed by single-particle cryo-EM | Cell Rep |
| Molecular insights into de novo small-molecule recognition by an intron RNA structure | PNAS |
| FlgY, PflA, and PflB form a spoke–ring network in the high-torque flagellar motor of Helicobacter pylori | PNAS |
| Structural basis for the interaction between the Drosophila RTK Sevenless (dROS1) and the GPCR BOSS | Nat Commun |
| A Helicobacter pylori flagellar motor accessory is needed to maintain the barrier function of the outer membrane during flagellar rotation | PLoS Pathog |
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| Title | Journal |
|---|---|
| Broadly conserved FlgV controls flagellar assembly and Borrelia burgdorferi dissemination in mice | Nat Commun |
| Vibrio cholerae RbmB is an α-1,4-polysaccharide lyase with biofilm-disrupting activity against Vibrio polysaccharide (VPS) | PLoS Pathog |
| Multiple mechanisms for licensing human replication origins | Nature |
| Cryo-EM structure of a photosystem I variant containing an unusual plastoquinone derivative in its electron transfer chain | Sci Adv |
| PilY1 regulates the dynamic architecture of the type IV pilus machine in Pseudomonas aeruginosa | Nat Commun |
| Elucidating bacterial coaggregation through a physicochemical and imaging surface characterization | Sci Total Environ |
| High-resolution in situ structures of mammalian respiratory supercomplexes | Nature |
| Dual function of LapB (YciM) in regulating Escherichia coli lipopolysaccharide synthesis | PNAS |
| Outer membrane vesicles and the outer membrane protein OmpU govern Vibrio cholerae biofilm matrix assembly | mBio |
| Episymbiotic Saccharibacteria TM7x modulates the susceptibility of its host bacteria to phage infection and promotes their coexistence | PNAS |
| Structure of the antenna complex expressed during far-red light photoacclimation in Synechococcus sp. PCC 7335 | J Biol Chem |
| Structure of a biohybrid photosystem I-platinum nanoparticle solar fuel catalyst | Nat Commun |
| Structure and inhibition of SARS-CoV-2 spike refolding in membranes | Science |
| Mutation-induced shift of the photosystem II active site reveals insight into conserved water channels | J Biol Chem |
| Structure of mavacamten-free human cardiac thick filaments within the sarcomere by cryoelectron tomography | PNAS |
| The molecular basis of sugar detection by an insect taste receptor | Nature |
| Native architecture of a human GBP1 defense complex for cell-autonomous immunity to infection | Science |
| GABAA receptor π forms channels that stimulate ERK through a G-protein-dependent pathway | Mol Cell |
| Mechanistic basis for the translation inhibition of Cutibacterium acnes by Clindamycin | J Invest Dermatol |
| A pleiotropic role of sialidase in the pathogenicity of Porphyromonas gingivalis | Infect Immun |
| Cryo-EM structures reveal how phosphate release from Arp3 weakens actin filament branches formed by Arp2/3 complex | Nat Commun |
| Bacterial flagella hijack type IV pili proteins to control motility | PNAS |
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| Title | Journal |
|---|---|
| Structural insights into intron catalysis and dynamics during splicing | Nature |
| Abl2 repairs microtubules and phase separates with tubulin to promote microtubule nucleation | Curr Biol |
| Cryo-EM reveals how the mastigoneme assembles and responds to environmental signal changes | J Cell Biol |
| Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport | Nat Struct Mol Biol |
| Anti-s28 Factor FlgM Regulates Flagellin Gene Expression and Flagellar Polarity of Treponema denticola | J Bacteriol |
| Structure of a dimeric photosystem II complex from a cyanobacterium acclimated to far-red light | J Biol Chem |
| A dual role for the chromatin reader ORCA/LRWD1 in targeting the origin recognition complex to chromatin | EMBO J |
| A protocol for capturing RNA-sensing innate immune receptors in multiple conformations by single-particle cryo-EM | STAR Protoc |
| Helical allophycocyanin nanotubes absorb far-red light in a thermophilic cyanobacterium | Sce Adv |
| Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention | PNAS |
| LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility | eLife |
| HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes | Nature |
| Structural basis for translation inhibition by MERSCoV Nsp1 reveals a conserved mechanism for betacoronaviruses | Cell Report |
| Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism | Nucleic Acids Res |
| Structural basis for recruitment of host CypA and E3 ubiquitin ligase by maedi-visna virus Vif | Sci Adv |
| FlgV forms a flagellar motor ring that is required for optimal motility of Helicobacter pylori | PLoS One |
| Ice nucleation proteins self-assemble into large fibres to trigger freezing at near 0 °C | eLife |
| Diacylglycerol-dependent hexamers of the SNARE-assembling chaperone Munc13-1 cooperatively bind vesicles | PNAS |
| The E3 ligase Riplet promotes RIG-I signaling independent of RIG-I oligomerization | Nat Commun |
| Parkinson’s disease kinase LRRK2 coordinates a cell-intrinsic itaconate-dependent defence pathway against intracellular Salmonella | Nat Microbiol |
| Gut colonization by Bacteroides requires translation by an EF-G paralog lacking GTPase activity | EMBO J |
| Bacteria require phase separation for fitness in the mammalian gut | Science |
| High-Resolution Structural Analysis of Dyneins by Cryo-electron Microscopy | Methods Mol Biol |
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| Title | Journal |
|---|---|
| Structures of a mobile intron retroelement poised to attack its structured DNA target | Science |
| Transcriptome of Epibiont Saccharibacteria Nanosynbacter lyticus Strain TM7x During the Establishment of Symbiosis | J Bacteriol |
| Exploitation of a Bacterium-Encoded Lytic Transglycosylase by a Human Oral Lytic Phage To Facilitate Infection | J Virol |
| Cryo-EM structures of prefusion SIV envelope trimer | Nat Struct Mol Biol |
| Regulatory mechanisms of lipopolysaccharide synthesis in Escherichia coli | Nat Commun |
| Identification and Characterization of the Alternative σ28 Factor in Treponema denticola | J Bacteriol |
| Multi-curve fitting and tubulin-lattice signal removal for structure determination of large microtubule-based motors | J Struct Biol |
| Monobody adapter for functional antibody display on nanoparticles for adaptable targeted delivery applications | Nat Commun |
| The flagellar motor protein FliL forms a scaffold of circumferentially positioned rings required for stator activation | PNAS |
| FliL ring enhances the function of periplasmic flagella | PNAS |
| Cryo-EM structure of an active central apparatus | Nat Struct Mol Biol |
| Transcriptional and functional characterizations of multiple flagellin genes in spirochetes | Mol Microbiol |
| Structural insights into the mechanism of the sodium/iodide symporter (NIS) | Nature |
| The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands | Mol Cell |
| Mechanism of actin filament branch formation by Arp2/3 complex revealed by a high-resolution cryo-EM structure of the branch junction | PNAS |
| Munc13 structural transitions and oligomers that may choreograph successive stages in vesicle priming for neurotransmitter release | PNAS |
| High-resolution cryo-electron microscopy structure of photosystem II from the mesophilic cyanobacterium, Synechocystis sp. PCC 6803 | PNAS |
| Single particle cryo-EM structure of the outer hair cell motor protein prestin | Nat Commun |
| Structures of the CcmABCD heme release complex at multiple states | Nat Commun |
| How to correct relative voxel scale factors for calculations of vector-difference Fourier maps in cryo-EM | J Struct Biol |
| In situ architecture of the lipid transport protein VPS13C at ER–lysosome membrane contacts | PNAS |
| Developmental transitions coordinate assembly of the Coxiella burnetii Dot/Icm type IV secretion system | Infect Immun |
| Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern | Cell Rep |
| Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617 | Nat Commun |
| An essential periplasmic protein coordinates lipid trafficking and is required for asymmetric polar growth in mycobacteria | eLife |
| A Tripartite Efflux System Affects Flagellum Stability in Helicobacter pylori | Int J Mol Sci |
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| Title | Journal |
|---|---|
| BB0259 Encompasses a Peptidoglycan Lytic Enzyme Function for Proper Assembly of Periplasmic Flagella in Borrelia burgdorferi | Front Microbiol |
| Characterization of the Flagellar Collar Reveals Structural Plasticity Essential for Spirochete Motility | mBio |
| Structure and analysis of nanobody binding to the human ASIC1a ion channel | eLife |
| Cryo-EM structure of the needle filament tip complex of the Salmonella type III secretion injectisome | PNAS |
| Structure of Geobacter pili reveals secretory rather than nanowire behaviour | Nature |
| Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism | Nat Struct Mol Biol |
| Structural basis of mismatch recognition by a SARS-CoV-2 proofreading enzyme | Science |
| Cryo-EM structures of Escherichia coli cytochrome bo3 reveal bound phospholipids and ubiquinone-8 in a dynamic substrate binding site | PNAS |
| Nodal modulator (NOMO) is required to sustain endoplasmic reticulum morphology | J Biol Chem |
| A human apolipoprotein L with detergent-like activity kills intracellular pathogens | Science |
| A mammalian system for high-resolution imaging of intact cells by cryo-electron tomography | Prog Biophys Mol Biol |
| Symmetrical arrangement of proteins under release-ready vesicles in presynaptic terminals | PNAS |
| A phase-separated nuclear GBPL circuit controls immunity in plants | Nature |
| Structural visualization of transcription activated by a multidrug-sensing MerR family regulator | Nat Commun |
| Interconnecting solvent quality, transcription, and chromosome folding in Escherichia coli | Cell |
| Role of the major determinant of polar flagellation FlhG in the endoflagella-containing spirochete Leptospira | Mol Microbiol |
| A CRISPR interference platform for selective downregulation of gene expression in Borrelia burgdorferi | Appl Environ Microbiol |
| Composition and Biophysical Properties of the Sorting Platform Pods in the Shigella Type III Secretion System | Front Cell Infect Microbiol |
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| Title | Journal |
|---|---|
| Cryo-EM Structure of Monomeric Photosystem II from Synechocystis sp. PCC 6803 Lacking the Water-Oxidation Complex | Joule |
| Dynamic and asymmetric fluctuations in the microtubule wall captured by high-resolution cryoelectron microscopy | PNAS |
| Structures of cofilin-induced structural changes reveal local and asymmetric perturbations of actin filaments | PNAS |
| The flagellar motor of Vibrio alginolyticus undergoes major structural remodeling during rotational switching | eLife |
| Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA | Mol Cell |
| Cryo-electron microscopy structures of pyrene-labeled ADP-Pi- and ADP-actin filaments | Nat Commun |
| Structural basis for the activation and suppression of transposition during evolution of the RAG recombinase | EMBO J |
| Molecular dysregulation of ciliary polycystin-2 channels caused by variants in the TOP domain | PNAS |
| Structure of the human cation-chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy | Nat Commun |
| Molecular mechanism for rotational switching of the bacterial flagellar motor | Nat Struct Mol Biol |
| Sub-Nanometer Structures of HIV-1 Envelope Trimers on Aldrithiol-2 Inactivated Virus Particles | Nat Struct Mol Biol |
| Insights into Lysosomal PI(3,5)P2 Homeostasis from a Structural-Biochemical Analysis of the PIKfyve Lipid Kinase Complex | Mol Cell |
| Electric field stimulates production of highly conductive microbial OmcZ nanowires | Nat Chem Biol |
| c-di-GMP modulates type IV MSHA pilus retraction and surface attachment in Vibrio cholerae | Nat Commun |
| Cryo-EM reconstruction of a VPS13 fragment reveals a long groove to channel lipids between membranes | J Cell Biol |
| FlhF regulates the number and configuration of periplasmic flagella in Borrelia burgdorferi | Mol Microbiol |
| BB0326 is responsible for the formation of periplasmic flagellar collar and assembly of the stator complex in Borrelia burgdorferi | Mol Microbiol |
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| Title | Journal |
|---|---|
| Structural basis of antagonism of human APOBEC3F by HIV-1 Vif | Nat Struct Mol Biol |
| A mitochondrial megachannel resides in monomeric F1FO ATP synthase | Nat Commun |
| High-resolution view of the type III secretion export apparatus in situ reveals membrane remodeling and a secretion pathway | PNAS |
| Structures of a RAG-like transposase during cut-and-paste transposition | Nature |
| A polymorphic helix of a Salmonella needle protein relays signals defining distinct steps in type III secretion | PLoS Biol |
| Structural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin | Nat Commun |
| Structure of Microbial Nanowires Reveals Stacked Hemes that Transport Electrons over Micrometers | Cell |
| Mechanism of actin polymerization revealed by cryo-EM structures of actin filaments with three different bound nucleotides | PNAS |
| Symmetrical organization of proteins under docked synaptic vesicles | FEBS Lett |
| Structural dynamics of bacteriophage P22 infection initiation revealed by cryo-electron tomography | Nat Microbiol |
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| Title | Journal |
|---|---|
| The actin filament twist changes abruptly at boundaries between bare and cofilin-decorated segments | J Biol Chem |
| Structural basis of the filamin A actin-binding domain interaction with F-actin | Nat Struct Mol Biol |
| Visualization of the type III secretion mediated Salmonella–host cell interface using cryo-electron tomography | eLife |
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