siRNA library

The Dharmacon siGenome human genome library consists of 18,081 genes with updated annotation arrayed in 58, 384-well plates. Four siRNA duplexes targeting different regions of a single gene are pooled into a single well. The library is made up of three subsets.

Druggable genome (9 plates; 2,732 genes): Includes ion channels, proteases, phosphatases, kinases, ubiquitin conjugation proteins and G-protein-coupled receptors. Download list of gene symbols.

Drug targets (15 plates; 4,793 genes): Includes genes involved in apoptosis, senescence, nucleic acid binding, autophagy, DNA repair, characterized nuclear receptors and potential therapeutic targets. Download list of gene symbols.

Human genome (34 plates; 10,556 genes): Includes genes not contained in other subsets including uncharacterized genes. Download list of gene symbols.

Please contact Yulia Surovtseva for the current per-assay plate fee structure applicable to your project. Screening plates have a per-assay plate fee structure dependent on the type of screen (compound or siRNA).