UltraMild synthesis

Some modifications require the use of UltraMild columns, phosphoramidites, and reagents that allow for mild cleavage and deprotection conditions. Some of these modifications include:

• cyanine dyes including Cy3, Cy3.5, Cy5 and Cy5.5
• TAMRA-dT and 3'-TAMRA
• acridine
• etheno-dA
• 5,6-Dihydro-dU
• 5'-iodo-dT
• 5'-OH-dU
• 5'-OH-dC
• thymidine glycol

The price of these UltraMild columns, phosphoramidites and reagents along with the price of any modified phosphoramidites will be added to the normal oligo price.

See our modifier pricing page for UltraMild reagent prices.