Core/facility:
Keck Oligo Synthesis Resource
RNA & 2'-O-methyl RNA
- We synthesize RNA and 2'-O-methyl RNA only at the 1.0 µmole scale.
- For RNA oligos longer than 60 bases, we use TOM-protected RNA monomers. For RNA oligos 60 bases or fewer, we use the standard TBDMS-protected RNA monomers.
- Unless the Cartridge Purification option is selected, we supply all RNA with a 2' protecting group (TOM or TBDMS), which must be removed by the researcher before use. Visit our protocol page for the protocols. We remove all protecting groups from 2'-O-methyl RNA and cartridge-purified RNA.
- Turnaround times for RNA are typically 5–10 business days.
- Chimers of DNA/RNA (or 2'-O-methyl RNA) are also available. These orders may be submitted via the Order Modified Oligos page.