Comparative Pathology Research (CPR) Support
About the service
Comparative Pathology Research Support provides the opportunity for researchers using animal models of disease to work together with an experienced research veterinarian trained in anatomic veterinary pathology on short- or long-term projects requiring expertise in the evaluation, diagnosis, and documentation of macroscopic, microscopic, ultrastructural, and clinical pathologic findings in rodents and other species.
Services
- Histopathologic analysis for individual organs, tissues or whole mouse phenotyping.
- Detailed gross necropsy and microscopic tissue evaluation.
- Individual tissue evaluation including semi-quantitative analysis for specific parameters.
- Publication-quality macroscopic and microscopic images with descriptions for figure legends and the relevant sections of manuscripts and grants.
- Immunohistochemistry (IHC) and electron microscopy (EM) and other types of tissue analysis. Although our team does not provide IHC or EM directly, we do coordinate with other core services at Yale for IHC and EM and then provide the detailed tissue analysis.
- Study design: Assistance is available to assist with study design, experimental mouse models, pathology protocols, and data analysis for research project involving research using animals.
- Grant support: Letters of support and other documents required for submitting grants using our service can be provided if requested within 2 business days of the deadline set by Yale Office of Sponsored Projects.
Note: Research necropsies must be scheduled in advance and, unless absolutely essential and with prior agreement, must be performed during normal business hours. For time-sensitive, unplanned necropsies, we will do our best to accommodate the investigator. For external projects, necropsy and tissue collection at the customer's institution is an option in some cases.
Available to Yale researchers & external researchers
Order form
Internal users, please go to LSOG 109 and fill out the in-person triplicate submission form, or email us. External users, please email us. Effective 12/1/25, All submissions will be made through the PPMS system.
Getting started
Email Dr. Booth, Core Director, to arrange a meeting to discuss your project before submitting samples and (ideally) before starting your project as experimental protocols, e.g., fixation choice, duration, and volume significantly, can impact the final product. Determination of the optimal experimental design, tissue collection, and fixation and plan ultimately reduces expense and improves quality. Each PI receives one hour of free consultation. Afterward, an hourly consulting fee is applied.
Please be advised that a valid internal account (COA) or external billing information is required prior to the initiation of services.
For examples of the different types of research, please see Dr. Booth’s NCBI current research publication list.
Rates
Mouse Research Pathology Support is the only USP at the Yale School of Medicine providing pathologic phenotyping by comparative veterinary pathologists. In addition to gross and histologic evaluation of animal models, we also provide a variety of high-quality histology services tailored to individual projects.
Rates effective 1/1/25.
| Services | Unit | Yale research investigator | External research investigator |
|---|---|---|---|
| C&T technical time | per hour | $79.50 | $119.72 |
| M&P technical time | per hour | $79.00 | $115.00 |
| Pathologist | per hour | $140.00 | $204.50 |
| Necropsy: Research: Rodent (supplies only), for research animals only | per necropsy | $5.00 | $116.00 |
| Histology: Tissue processing only | per sample | $10.00 | $0 |
| Histology: Tissue processing and embedding | per sample | $12.25 | $35.00 |
| Histology: Tissue processing, embedding, sectioning, 1st H&E Slide | per sample | $21.00 | $65.50 |
| Histology: Cut unstained section from block (1-2 sections on one slide) | per slide | $3.50 | $14.75 |
| Histology: H&E slide | per slide | $5.25 | $69.00 |
| Histology: Special stains, non-silver stain only; no sectioning | per slide | $11.75 | $45.00 |
| Histology: Silver stain only; no sectioning | per slide | $21.00 | $83.00 |
| Histology: Frozen sectioning | per section | $21.00 | $400.00 |
| Microbiology: Aerobic culture, including Pseudomonas screening culture, urine cultures, cecal screening culture | per sample | $88.00 | $0 |
| Microbiology: Anaerobic culture | per sample | $130.00 | $0 |
| Microbiology: Antibiotic sensitivity -- group 1 | per sample | $84.00 | $0 |
| Microbiology: Antibiotic sensitivity -- group 2 | per sample | $84.00 | $0 |
| Microbiology: Blood culture | per sample | $145.00 | $0 |
| Microbiology: Diff Quik stain | per sample | $34.00 | $0 |