Listing of research core items
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Services
Cellular and mitochondrial respiration and bioenergetics
Cellular and mitochondrial respiration (OCR) and acidification (ECAR) are assessed with the Agilent Seahorse XF Pro 96. In a 96-well plate format, real-time measurements of cellular respiration, oxidative phosphorylation, mitochondrial leak, and mitochondrial transport are assessed as functional kinetic measurements of cellular bioenergetics. Changes in acidification are also observed simultaneously. An integrated Agilent BioTek Cytation5 imager correlates cell number via Hoechst nuclear stain to respiration for more accurate normalization of respiration.
Located within Chemical Metabolism CoreRebecca Cardone, MS
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Instrument/equipment
BD LSR Fortessa X20
The Fortessa analyzer has 4 lasers, including V 405 nm, B 488 nm, YG 561 nm, and R 640 nm. It can detect 16 colors.
Located within Science Hill Flow Cytometry FacilityFreya Wencker, PhD
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Instrument/equipment
BD Symphony A1 analyzer
Analyze from single tubes or 96-well plates with 45 lasers (violet, blue, yellow/green, red) and 64 detectors (6 violet, 2 blue, 4 yellow/green, 3 red).
Located within West Campus Flow Cytometry Facility -
Core/facility
YSM Biobank
Contact YSM Biobank for the full spectrum of your biorepository needs: consenting, collection, processing, storage, distribution, data access, grant application support, IRB compliance, and more.
Primary contact
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Instrument/equipment
Biocore 8K SPR (Surface Plasmon Resonance) system
State-of-the-art Biacore™ 8K SPR system from Cytiva, part of the advanced Biacore™ 8 series.
Located within Yale Center for Molecular Discovery -
Core/facility
Keck Biophysical Resource
As of 2026, the Keck Biophysical Resource will no longer be available for services except for NIDA investigators, who will still have access to some technologies.
Ewa Folta-Stogniew, PhD, MSc
Director (Retired) -
Instrument/equipment
BD Symphony S6 cell sorter
Sort into 5 mL round tubes, 15 mL conical tubes, or plates (24-, 48-, and 96-well) with 5 lasers (UV, violet, blue, yellow/green, red) and 23 detectors (6 UV, 6 violet, 4 blue, 4 yellow/green, 3 red).
Located within West Campus Flow Cytometry Facility -
Instrument/equipment
Flow cytometry cell sorting
Sort requests can be scheduled via PPMS. You must have a valid account and CoA on file to request a sort. Depending on the cell type being investigated, there are a variety of procedures for preparing cells.
Located within Yale Flow Cytometry Facility -
Core/facility
Yale Center for Molecular Discovery
We provide resources for assay development and high-throughput screening with small molecules and arrayed siRNA and sgRNA/CRISPR libraries in biochemical, cell-based and image-based assays (primarily 384-well format).
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Core/facility
Chemical Metabolism Core
Previously called the Islet, Oxygen consumption, Mass Isotopomer flux Core (IOMIC), the Chemical Metabolism Core offers targeted and untargeted metabolomics, stable isotope-based metabolic flux analysis, quantitative metabolic panels of central carbon metabolism and adjacent pathways, measurements of cellular bioenergetics, islet isolation and functional studies. Services include study assistance and data analysis.
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Core/facility
CMC Live-Cell Imaging Core (CLIC)
Affiliated with the Chemical Metabolism Core (CMC), the Live Cell Imaging Core (CLIC) offers assessments of metabolites, live-cell imaging, biosensor design and delivery, perfusion assays, a library of dyes and biosensors, and more.
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Core/facility
Comparative Pathology Research Core
We offer pathology support for animal-based studies, including histopathology, necropsy, and microbiology, as well as assistance with study design.