Cores Directory
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Listing of research core items
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Services
Metabolic flux and enrichment studies using MIMOSA
In this subcore, parameters of cellular and tissue metabolic flux are assessed by incorporation of stable isotope-labeled tracers (e.g., carbon-13, nitrogen-15, or deuterium) into metabolism. The CMC uses the targeted mass isotopomer multi-ordinate spectral analysis (MIMOSA) platform to interpret stable isotope labeling patterns for calculation of rates of discrete steps in glycolytic and mitochondrial metabolism. Such measurements can be used to identify differences in fuel usage (e.g., glycolysis vs. beta-oxidation), and non-oxidative (reductive carboxylation, anaplerosis and cataplerosis) contributions to the TCA cycle.
Located within Chemical Metabolism CoreStephan Siebel, MD, PhD
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Islet isolation and function
In this subcore, our technical expertise in isolating rodent islets including rats, mice, and most recently ground squirrel from the pancreas ex vivo allows researchers to study the intact islets for their studies or to proceed with substrate-stimulated insulin secretion functional studies using our BioRep Technologies Islet Perfusion Systems (8-channel and 12-channel). For non-rodent islet studies, human donor islet procurement assistance as well as functional studies are also offered.
Located within Chemical Metabolism CoreRebecca Cardone, MS
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Elemental abundance
Services for measuring the abundance of elements in a sample
Located within Yale Analytical and Stable Isotope Center (YASIC) -
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Gas chromatography
Measure greenhouse gas concentrations.
Located within Yale Analytical and Stable Isotope Center (YASIC) -
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Glass shop products
Examples of our offerings include adapters, bubblers, bump traps, chromatography columns, condensers, dry-storage jars, filtration funnels, flasks, Kjeldahl traps, Schlenk ware, and vacuum traps.
Located within Scientific Glassblowing Laboratory (Glass Shop)Daryl Smith
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Isotope ratio mass spectrometry (IRMS)
Isotope ratio mass spectrometry (IRMS) services
Located within Yale Analytical and Stable Isotope Center (YASIC) -
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Assorted machine shop services
Loans, spare parts, and materials
Located within YSM Electronic & Machine ShopAnthony DeSimone
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Custom machining
The Machine Shop provides custom machining for Yale and the local community.
Located within YSM Electronic & Machine ShopAnthony DeSimone
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Radiocarbon
Our mission is to provide high-quality radiocarbon dating services to support research in various scientific fields, from archaeology and geology to climate science.
Located within Yale Analytical and Stable Isotope Center (YASIC) -
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Services
Cutting; grinding; drilling; ultrasonic cleaning; evacuation, backfilling, and tipping off vessels; custom design and consultation.
Located within Scientific Glassblowing Laboratory (Glass Shop)Daryl Smith