Cores Directory
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Listing of research core items
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Services
Metabolic flux and enrichment studies using MIMOSA
In this subcore, parameters of cellular and tissue metabolic flux are assessed by incorporation of stable isotope-labeled tracers (e.g., carbon-13, nitrogen-15, or deuterium) into metabolism. The CMC uses the targeted mass isotopomer multi-ordinate spectral analysis (MIMOSA) platform to interpret stable isotope labeling patterns for calculation of rates of discrete steps in glycolytic and mitochondrial metabolism. Such measurements can be used to identify differences in fuel usage (e.g., glycolysis vs. beta-oxidation), and non-oxidative (reductive carboxylation, anaplerosis and cataplerosis) contributions to the TCA cycle.
Located within Chemical Metabolism CoreStephan Siebel, MD, PhD
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Islet isolation and function
In this subcore, our technical expertise in isolating rodent islets including rats, mice, and most recently ground squirrel from the pancreas ex vivo allows researchers to study the intact islets for their studies or to proceed with substrate-stimulated insulin secretion functional studies using our BioRep Technologies Islet Perfusion Systems (8-channel and 12-channel). For non-rodent islet studies, human donor islet procurement assistance as well as functional studies are also offered.
Located within Chemical Metabolism CoreRebecca Cardone, MS
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Comparative Pathology Research (CPR) Support
Expertise in the evaluation, diagnosis, and documentation of macroscopic, microscopic, ultrastructural, and clinical pathologic findings in rodents and other species.
Located within Comparative Pathology Research Core -
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Elemental abundance
Services for measuring the abundance of elements in a sample
Located within Yale Analytical and Stable Isotope Center (YASIC) -
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EM CCMI services
Project consultation and experimental design, sample preparation, and imaging with transmission and scanning electron microscopes.
Located within Electron Microscopy Facility at CCMI -
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Gas chromatography
Measure greenhouse gas concentrations.
Located within Yale Analytical and Stable Isotope Center (YASIC) -
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Imaging services
Micro-CT, pulse Doppler, and imaging analysis.
Located within Yale CVRC Micro-CT Imaging CoreZhen Zhuang, MD, MS
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Isotope ratio mass spectrometry (IRMS)
Isotope ratio mass spectrometry (IRMS) services
Located within Yale Analytical and Stable Isotope Center (YASIC) -
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Data storage and computing
BrainWorks data products are archived, processed, and shared on the Milgram computing cluster.
Located within BrainWorks -
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Pavlovia
Pavlovia is a platform for running and sharing online experiments.
Located within BrainWorksRoeland Hancock
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Radiocarbon
Our mission is to provide high-quality radiocarbon dating services to support research in various scientific fields, from archaeology and geology to climate science.
Located within Yale Analytical and Stable Isotope Center (YASIC)