Cores Directory
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Listing of research core items
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Services
Cellular and mitochondrial respiration and bioenergetics
Cellular and mitochondrial respiration (OCR) and acidification (ECAR) are assessed with the Agilent Seahorse XF Pro 96. In a 96-well plate format, real-time measurements of cellular respiration, oxidative phosphorylation, mitochondrial leak, and mitochondrial transport are assessed as functional kinetic measurements of cellular bioenergetics. Changes in acidification are also observed simultaneously. An integrated Agilent BioTek Cytation5 imager correlates cell number via Hoechst nuclear stain to respiration for more accurate normalization of respiration.
Located within Chemical Metabolism CoreRebecca Cardone, MS
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Clinical Trial Tissue Services (CTTS)
The mission of Clinical Trial Tissue Services is to provide the Yale community and clients around the world with high quality formalin-fixed paraffin embedded material (FFPE) to promote and facilitate research.
Located within Yale Pathology Tissue Services (YPTS) -
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Comparative Pathology Research (CPR) Support
Expertise in the evaluation, diagnosis, and documentation of macroscopic, microscopic, ultrastructural, and clinical pathologic findings in rodents and other species.
Located within Comparative Pathology Research Core -
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Genome editing using CRISPR/Cas9 technique
Gene knockout, single or a few nucleotides replacement and insert reporters in specific locus in hESCs and iPSCs using CRISPR/Cas9 technology.
Located within Human Embryonic/Induced Pluripotent Stem Cell Core -
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Developmental Histology/Tissue Microarray & Archiving
Developmental Histology/Tissue Microarray is a shared resource of the Yale Cancer Center & Yale Pathology Tissue Services.
Located within Yale Pathology Tissue Services (YPTS) -
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EM CCMI services
Project consultation and experimental design, sample preparation, and imaging with transmission and scanning electron microscopes.
Located within Electron Microscopy Facility at CCMI -
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Other flow cytometry services
Many lines of hands-on services by facility staff are available. Staff can operate any analytic cytometer for you to acquire data on your behalf. Staff are also available to analyze data if needed.
Located within Yale Flow Cytometry FacilityYale Flow Cytometry Facility
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Histology Service
Preparation of animal tissues for microscopic examination.
Located within Comparative Pathology Research Core -
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Imaging services
Micro-CT, pulse Doppler, and imaging analysis.
Located within Yale CVRC Micro-CT Imaging CoreZhen Zhuang, MD, MS
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In vitro assays and cancer models
3D and explant cultures, cytotoxicity assays, and immunoassays.
Located within Precision Cancer ModelingVish Muthusamy, PhD
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In vivo cancer models
Cell line-derived xenograft (CDX) models, patient-derived xenograft (PDX) models, syngeneic models, genetically engineered mouse models (GEMMS), metastasis models.
Located within Precision Cancer ModelingVish Muthusamy, PhD
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Induced pluripotent stem cell (iPSC) production
We reprogram fully differentiated somatic cells to induced pluripotent stem cells (iPSCs).
Located within Human Embryonic/Induced Pluripotent Stem Cell Core