Listing of research core items
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Core/facility
Yale Center for Molecular Discovery
We provide resources for assay development and high-throughput screening with small molecules and arrayed siRNA and sgRNA/CRISPR libraries in biochemical, cell-based and image-based assays (primarily 384-well format).
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Core/facility
Chemical Metabolism Core
Previously called the Islet, Oxygen consumption, Mass Isotopomer flux Core (IOMIC), the Chemical Metabolism Core offers targeted and untargeted metabolomics, stable isotope-based metabolic flux analysis, quantitative metabolic panels of central carbon metabolism and adjacent pathways, measurements of cellular bioenergetics, islet isolation and functional studies. Services include study assistance and data analysis.
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Instrument/equipment
Chemical vapor deposition
The chemical vapor deposition (CVD) tools can deposit metal, oxide, and nitride thin films. The cleanroom offers various CVD tools, including plasma-enhanced CVD and atomic layer deposition.
Located within Yale Cleanroom Facilities -
Core/facility
Yale Cleanroom Facilities
The University Cleanroom provides a controlled environment that maintains intentionally low concentrations of pollutants to allow for uncontaminated scientific research.
Yong Sun & Lauren McCabe
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Services
Comparative Pathology Research (CPR) Service
Expertise in the evaluation, diagnosis, and documentation of macroscopic, microscopic, ultrastructural, and clinical pathologic findings in rodents and other species.
Located within Comparative Pathology Research Core -
Core/facility
Comparative Pathology Research Core
We offer pathology support for animal-based studies, including histopathology, necropsy, and microbiology as well as assistance with study design.
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Core/facility
Confocal Microscopy at CCMI
We offer confocal microscopy, two-photon microscopy, light-sheet microscopy, swept-field microscopy, super-resolution imaging, and image analysis services.
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Services
Genome editing using CRISPR/Cas9 technique
Gene knockout, single or a few nucleotides replacement and insert reporters in specific locus in hESCs and iPSCs using CRISPR/Cas9 technology.
Located within Human Embryonic/Induced Pluripotent Stem Cell Core -
Core/facility
Yale CryoEM Resource
The Yale CryoEM Resource comprises electron microscopes on all 3 campuses: a Titan Krios on West Campus, a Glacios and a Tecnai T12 at Yale School of Medicine, and a Glacios and a Talos L120C on Science Hill.
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Core/facility
CyTOF Facility
Time-of-flight mass spectrometer for multi-parametric single cell data
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Core/facility
Yale University Cytogenetics Laboratory
The core provides testing for cancer predisposition, metabolic and developmental disorders.
DNA Diagnostics Lab
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Instrument/equipment
Differential scanning calorimetry (DSC)
This instrument measures the heat flow of materials across phase transitions. Technical specifications and limits of the equipment are listed below.
Located within Mechanical and Thermal Analysis Instrumentation Core (MTAIC)