Chemical Metabolism Core
The Chemical Metabolism Core provides resources for measuring islet function, oxygen consumption, and cellular metabolic flux.
About the core
Previously called the Islet, Oxygen consumption, Mass Isotopomer flux Core (IOMIC), the Chemical Metabolism Core measures islet function, oxygen consumption, and cellular metabolic flux. Services include study assistance and data analysis.
Services
- Rodent islet isolation (single and multiple)
- Human or rodent islet study
- Intact islet perfusion study
- Islet reaggregate dynamic static incubation study for hormone secretion
Metabolic flux and enrichment studies using MIMOSA (mass isotopomer multiordinate spectral analysis)
- Steady-state measurements of mitochondrial metabolism
Global metabolomics and integrative -omics (IntOmics)
- 4-mode and 2-mode metabolomics
- Real-time live-cell measurement of mitochondrial respiration and glycolysis
- Cellular respiration, oxidative phosphorylation, motility, and transport pathways
Contacts
Contact us for sample drop-off or shipment.
Primary contact
Faculty Director
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Core/Facility
Keck Biophysical Resource
We offer resources to study the oligomeric state of biomolecular assemblies as well as the thermodynamics and kinetics of macromolecular interactions.
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Core/Facility
Yale Center for Genome Analysis (YCGA)
The Yale Center for Genome Analysis is a full-service facility dedicated to providing RNA expression profiling, DNA genotyping, and high-throughput sequencing using state-of-the-art technologies.
Primary contact
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Core/Facility
Yale Center for Molecular Discovery
We provide resources for assay development and high-throughput screening with small molecules and arrayed siRNA and sgRNA/CRISPR libraries in biochemical, cell-based and image-based assays (primarily 384-well format).