Heart study finds faulty link between biomarkers and clinical outcomes
Surrogate endpoints (biomarkers), which are routinely used in clinical research to test new drugs, should not be trusted as the ultimate measure to approve new health interventions in cardiovascular medicine, according to a recent study by Yale School of Medicine researchers in JAMA.
Yale’s Helen Caines takes a leadership role in international STAR experiment
The Yale physicist is co-leading a search for the theorized “critical point” that transformed the universe from a soup of quarks into what we know as matter today.
Next step in depression treatment? Add rather than switch
Millions of patients suffering from major depression get little relief from the first drug they are prescribed. A major new study of 1,522 patients at 35 U.S. Veterans Health Administration medical centers shows these patients benefit more from adding an antidepressant treatment than from switching to another one.
A cosmic barbecue: Researchers spot 60 new ‘hot Jupiter’ candidates
Yale researchers have identified 60 potential new “hot Jupiters” — highly irradiated worlds that glow like coals on a barbecue grill and are found orbiting only 1% of Sun-like stars.
“Rewiring” Our Fight Against Infection
John MacMicking of the Systems Biology Institute talks about his work to integrate abstract and experimental science in an effort to “rewire” the host immune response to infection. Dr. MacMicking is an Investigator of the Howard Hughes Medical Institute (HHMI) and tenured Associate Professor of Microbial Pathogenesis and of Immunobiology at the School of Medicine.
Drug restores cells and memories in Alzheimer’s mouse models
A new drug can restore memories and connections between brain cells in mice with a model of Alzheimer’s disease, a new Yale-led study suggests.
Long-time-lapse nanoscopy provides leisurely view of cell interior
New nanoscopy technology reveals interior of the cells with more clarity for longer periods than ever before, Yale researchers report in the July 3 issue of the journal Nature Biotechnology. Yale’s Derek Toomre and Alanna Schepartz explain how the technology is opening up a host of new research possibilities.